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High gradient magnetic field generator

A high-gradient magnetic field and generating device technology, which is applied in magnetic therapy, medical science, radiotherapy, etc., can solve the problems of difficulty in increasing the magnetic field gradient and troubles

Inactive Publication Date: 2004-07-14
华中科技大学同济医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This kind of artificially implanted magnet aims to solve the deep guide target, but it needs surgery to complete, which is troublesome
③A bipolar electromagnet is used, but the magnetic field gradient is still difficult to improve

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Doxorubicin-Bovine Serum Albumin Magnetic Microspheres Antitumor Test on S180 Magnetic Field Targeting:

[0034] 1. Preparation: ① Doxorubicin-Bovine Serum Albumin Magnetic Microsphere Suspension: 15ml contains 7mg of Doxorubicin, 70mg of Albumin, Fe 3 o 4 (20nm) 14mg. ② Physiological saline.

[0035] 2. Tumor strain and experimental method: 30 male Kunming mice (body weight 21-22g) were routinely inoculated with S180 tumor strain, divided into 3 groups, and when the tumor volume proliferated to 20mm 3 At left and right, 0.2ml normal saline, 0.2ml doxorubicin-bovine serum albumin magnetic microsphere fluid, 0.2ml doxorubicin-bovine serum albumin magnetic microsphere fluid were intravenously injected respectively, and a high gradient three Grab the vortex magnetic field for 30min. Five days after one-time administration, the animals were sacrificed, the tumors were weighed, and the difference in tumor weight between each group and the blank control group was compared...

Embodiment 2

[0037] Based on (Japan) Jianji Wenshi's guiding theory and experimental model, the ferritin (commercially available, brown-red deep liquid, containing 30% iron) was tested for guiding the target.

[0038] Pre-inject 50ml of distilled water (second boil) into the simulated blood vessel, and then inject 10ml of ferritin solution, so that the above-mentioned diluted liquid circulates in the simulated blood vessel and applies the high gradient magnetic field constructed by the present invention to the target site. The inner diameter of the tube is 0.5mm, and the flow rate is respectively 30min for 10cm / s and 3cm / s magnetic field action time. Samples were taken from the target site and non-target site for inspection, and the Fe content was measured with an atomic absorption spectrophotometer (HITACH180-80).

[0039] result:

[0040] Iron content of non-target site: iron content of target site = 1:1.26-1.54, indicating that the high-intensity and high-gradient magnetic field of the...

Embodiment 3

[0042] The high-gradient magnetic field generating device of the present invention is composed of a three-claw magnetic field meter and a capacitive discharge pulse magnetic field. The three-claw magnetic field meter is composed of a three-claw magnetic field magnetic circuit device at the top and a fixed base plate (8) with a central hole at the bottom. The three-claw magnetic field magnetic circuit device is composed of a rectangular parallelepiped S1-N1 pole head (3), S2-N2 magnetic block (1) and S3-N3 magnetic block (2), which are evenly distributed in a three-claw shape with On the plane of the fixed bottom plate (8) of the center hole, the N end of the S1-N1 pole head (3) and the S end of the S2-N2 magnetic block (1) and the S3-N3 magnetic block (2) face the center, and the The S1-N1 pole head (3) in the three-jaw magnetic field magnetic circuit is bonded by two bar-shaped permanent magnets and a bar-shaped pure iron, and the bar-shaped pure iron is located in the middle ...

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Abstract

The high gradient magnetic field generator features that it consists of three-pawl magnetic field instrument and capacitive discharge pulse magnetic field. The three-pawl magnetic field instrument consists of upper three-pawl magnetic field magnetic path device and lower fixing base board with central hole; and the electric pulse magnetic field consists of pulse power source for capacitor discharge and exciting winding on the S1-N1 pole head in the three-pawl magnetic field magnetic path device. The present invention has raised magnetic field gradient and strength and is suitable for use in the magnetic target treatment of superficial and deep tumor and animal experiment. The present invention has the advantages of high magnetic field gradient, long magnetic action distance, convenient operation, etc.

Description

technical field [0001] The invention relates to an in vitro targeting device for magnetic drug targeting therapy of malignant tumors. Background technique [0002] The treatment of cancer mainly adopts surgical treatment, chemotherapy, and radiotherapy at present. At the same time, biological therapy, targeted drug and gene therapy are developing rapidly, and all countries attach great importance to it. Chemotherapy is still an important means of cancer treatment, but chemotherapeutic drugs such as doxorubicin have serious side effects, and their clinical application is strictly limited such as injection dose and frequency. Even when severe side effects occur, the treatment has to be interrupted. At the end of the last century, a kind of guided drug—antibody-drug conjugate appeared. Through the specificity of the antibody, the drug can be aggregated to the target site, which improves the curative effect. However, due to the low strength of the connection between the antibo...

Claims

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Application Information

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IPC IPC(8): A61B5/06A61M36/00A61N2/04
Inventor 李剑星许冰黄杰祝家贵罗义铭
Owner 华中科技大学同济医学院
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