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Prepn process of tripterygium extractive

A technology of Tripterygium wilfordii and extracts, which is applied in the field of preparation of Chinese herbal medicine extracts, can solve the problems of long extraction time of active ingredients of Tripterygium wilfordii, unfavorable separation work, and low production efficiency, so as to avoid scald accidents, improve the working environment, and occupy The effect of small area

Inactive Publication Date: 2004-06-23
浙江得恩德制药股份有限公司
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

The crude extract of Tripterygium wilfordii extracted by this process has a higher interest rate (about 12‰), but the components are more miscellaneous, so the activity contained in the components is also low, which is not conducive to the next step of separation.
The common point of the above three processes is that the extraction time of the effective components of Tripterygium wilfordii is long and the production efficiency is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Stir 420kg of Tripterygium wilfordii medicinal material coarse powder with 80% ethanol to fully moisten the medicinal material, put the moistened medicinal material into the extraction column, seal the extraction column, turn on the vacuum pump to extract the air in the extraction column, and control the vacuum degree at 0.08Mpa , into a proper amount of ethanol to make the medicinal materials just submerged, and then pressurized by compressed air for 10 minutes, the pressure is 0.02Mpa, and then the dynamic countercurrent low-temperature sleeve extraction operation is carried out, and the extraction temperature is 25°C.

[0013] The device used for dynamic countercurrent low temperature jacket extraction is 6 closed series extraction columns. Add 110kg of 80% ethanol to the first extraction column, turn on the circulation pump, let the ethanol pass through the medicinal materials from bottom to top for countercurrent extraction, the required time is 40 minutes, and the ...

Embodiment 2

[0016] The difference between embodiment 2 and embodiment 1 is that the time of pressurization is 30 minutes, the time used for extraction is 50 minutes, the extraction temperature is at 30 ℃, the organic solvent used is methanol, and its total consumption is 840kg. The agent is dichloromethane, and the extraction yield is 12.6‰.

Embodiment 3

[0018] The difference between embodiment 3 and embodiment 1 is that the extraction column used is 12, the amount of medicinal materials added is 840kg, the concentration of ethanol used is 60%, and the total consumption is 1680kg. After each ethanol is added, flow through 11 extraction columns. column, the extraction yield was 11.5‰.

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Abstract

The present invention is the preparation process of tripterygium extractive. The preparation process includes low temperature dynamic countercurrent extraction of tripterygium material with organic solvent, decompressing concentration of the extracted liquid, extraction of the concentrated liquid with organic solvent, normal pressure recovering of organic solvent and vacuum drying to obtain coarse tripterygium extractive. The said process has short extraction period, reduced organic solvent throwing amount, low power consumption for recovering organic solvent, less damage to the effective components of tripterygium, high extraction rate of the effective components and high product quality.

Description

technical field [0001] The invention relates to a preparation process of an extract of Chinese medicinal materials, in particular to a preparation method of a crude extract of Tripterygium wilfordii. Background technique [0002] The Chinese herbal medicine Tripterygium wilfordii belongs to the Euonymus family Tripterygium genus. It is used to treat more than 30 kinds of immune diseases such as rheumatoid arthritis, chronic kidney disease, and lupus erythematosus. terpene components. The extraction techniques of the active ingredients of Tripterygium wilfordii include water extraction and alcohol precipitation, alcohol extraction, and ethyl acetate extraction. Water extraction and alcohol precipitation method: Tripterygium wilfordii is decocted twice with drinking water about 25 times the amount of the medicinal material, the resulting aqueous solution is concentrated and then added with alcohol, then the ethanol is recovered, extracted with chloroform three times, and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P13/12A61P19/02A61P37/02B01D11/02C07B63/00C07D493/14
Inventor 金春晖章国林张永昌刘法千潘新妃
Owner 浙江得恩德制药股份有限公司
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