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Bear gall granular formulation and preparing method thereof

A technology of bear bile and granules, which is applied in the direction of medical formulas, medical preparations containing active ingredients, bulk transportation, etc. It can solve the problems of easy moisture absorption, single dosage form, and easy deliquescence, etc., and achieves convenient consumption, good taste, Ease of transport

Inactive Publication Date: 2004-04-21
庄丽纯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Domestic existing preparations only have "bear bile capsule" as a single drug preparation, and most of the others are compound preparations; and health care products mainly include bear bile powder (medicinal material) and bear bile wine in small packages, but due to their extremely bitter taste, Fishy, ​​easy to deliquescence, its consumption is all less, and this has just greatly limited and weakened its remarkable treatment, the practical effect of health care; The method of coating after making granules is solved, but so far there is no report on the method of fundamentally solving its bitterness, fishy smell, and easy moisture absorption problems, so the dose-effect of bear bile cannot be brought into full play, and single-flavored bear bile A single form of Chinese patent medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0025] A. Weigh each raw material according to the ratio:

[0026] Bear bile powder 75g, cyclodextrin 100g, starch 200g, dextrin 400g, sugar 3150g, licorice extract 60g, stevioside 2g, menthol 5g, peppermint oil 5g, lemon yellow 0.5 grams, sodium copper chlorophyllin 2.5 grams;

[0027] B, get bear bile powder and cyclodextrin to be dissolved in water and organic solvent respectively, make solution, stir and clathrate at the temperature of 25 degrees Celsius to 80 degrees Celsius, reclaim organic solvent and obtain clathrate through spray drying;

[0028] C. Mix the inclusion compound with starch, dextrin, sugar, licorice extract powder, stevioside, tartrazine, sodium copper chlorophyllin and other auxiliary materials to make granules, dry and granulate;

[0029] D, get the volatile auxiliary material menthol and peppermint oil, add ethanol to dilute and make it dissolve;

[0030] E. After taking C, add D and seal it for more than 4 hours, and divide it into bags to obtain 5...

example 2

[0032] A. Weigh each raw material according to the ratio:

[0033] Bear bile powder 100g, cyclodextrin 200g, starch 200g, dextrin 400g, sugar 3000g, licorice extract 80g, stevioside 1g, menthol 6g, peppermint oil 5g, lemon yellow 0.5 grams, sodium copper chlorophyllin 2.5 grams;

[0034] B, get bear bile powder and cyclodextrin to be dissolved in water and organic solvent respectively, make solution, stir and clathrate at the temperature of 25 degrees Celsius to 80 degrees Celsius, reclaim organic solvent and obtain clathrate through spray drying;

[0035] C. Mix the inclusion compound with starch, dextrin, sugar, licorice extract powder, stevioside, tartrazine, sodium copper chlorophyllin and other auxiliary materials to make granules, dry and granulate;

[0036] D, get the volatile auxiliary material menthol and peppermint oil, add ethanol to dilute and make it dissolve;

[0037] E. After taking C, add D and seal it for more than 4 hours, and divide it into bags to obtain ...

example 3

[0039] A. Weigh each raw material according to the ratio:

[0040] 900ml fresh bear bile, 100g bear bile powder, 110g cyclodextrin, 200g starch, 400g dextrin, 3100g sugar, 85g licorice extract, 1g stevioside, 6g menthol, peppermint 5 grams of oil, 0.5 grams of lemon yellow, 2.5 grams of sodium copper chlorophyllin;

[0041] B, get bear bile powder and cyclodextrin to be dissolved in water and organic solvent respectively, make solution, stir and clathrate at the temperature of 25 degrees Celsius to 80 degrees Celsius, reclaim organic solvent and obtain clathrate through spray drying;

[0042] C. Mix the inclusion compound with starch, dextrin, sugar, licorice extract powder, stevioside, tartrazine, sodium copper chlorophyllin, etc., make granules, and dry;

[0043] D, get the volatile auxiliary material menthol and peppermint oil, add ethanol to dilute and make it dissolve;

[0044] E. Take C, add D and seal it for more than 4 hours, divide it into bags to get 500 bags of 8 ...

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Abstract

A granular bear gall preparation is prepared from bear gall powder, cyclodextrin, starch, dextrin, sugar, liquorice extract and stevioside. Its advantages are less loss of bioactivity, and high curative effect.

Description

Technical field: [0001] The invention relates to a bear bile granule and a preparation method thereof. Background technique: [0002] Bear bile is the bile of the Ursidae black bear (Selenaretos Thibeta Cuver) or brown bear (Ursusaretos). Bear bile is one of the most valuable medicinal materials in the treasure house of traditional Chinese medicine in my country, and it has been used in clinical practice for thousands of years. According to the classics of traditional Chinese medicine "Shen Nong's Materia Medica", "Tang Materia Medica", and "Compendium of Materia Medica", bear bile is bitter in taste, cool in nature, returns to the spleen, gallbladder, heart meridian, non-toxic, and has the functions of clearing heat, calming the liver, and improving eyesight; Convulsions and convulsions, external treatment of red eyes, swelling and pain, and sore throat; the dosage is 0.3-1 g, mostly in the form of pills and powder, appropriate amount for external use, powdered or mixed wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61P1/16A61P3/06A61P9/12A61P11/04A61P27/02
Inventor 庄丽纯谭养成
Owner 庄丽纯
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