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Bear gall sugar-free buccal tablet as well as preparation method and application thereof

A technology of bear bile and bear bile powder, applied in the direction of application, medical preparations containing active ingredients, and devices for making medicines into special physical or taking forms, can solve the problem of weakening the role of bear bile in treatment and health care, health care The effect is not fully exerted, the dosage is small, etc., to achieve the effect of maintaining natural physiological activity, good taste, and reducing processing links

Pending Publication Date: 2021-10-15
江西国妙堂生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the domestic existing preparations only have a single herbal medicine preparation called "bear bile capsule", and most of the others are compound preparations; and health care products mainly include bear bile powder (medicinal material) and bear bile wine in small packages, but due to the smell of bear bile Extremely bitter, fishy, ​​easy to deliquescence, its dosage is less, which greatly limits and weakens the role of bear bile treatment and health care
At present, the problems of bitterness, fishy smell and moisture absorption of bear bile have not been fundamentally solved at home and abroad, so that the wide range of disease prevention and health care functions of bear bile cannot be fully brought into play.

Method used

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  • Bear gall sugar-free buccal tablet as well as preparation method and application thereof
  • Bear gall sugar-free buccal tablet as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091]Boil the bear bile containing 50g of bear bile powder for 30min, filter, add 300g of beta-cyclodextrin, add 20% ethanol, continue heating, stir and clathrate at 80°C for 60min, evaporate the ethanol, add 624g of dextrin , stevioside mixed evenly 6g, into a bear bile inclusion liquid. Spread the bear bile inclusion medicinal liquid on a plate, freeze-dry it at -45-50°C until the water content is below 5%, and sieve it into dry granules with a 20-mesh sieve; mix and dissolve 5 g of menthol and peppermint oil, add 6g of essence was evenly sprayed on the above-mentioned granules and mixed evenly, and finally 7g of talcum powder and 3g of magnesium stearate were added, mixed evenly, and pressed into 1000 tablets to obtain bear bile sugar-free lozenges. Each tablet weighs 1.0g and contains bear bile powder 50mg / tablet.

Embodiment 2

[0093] With embodiment 1, difference is that the bear bile raw material is the aqueous solution of the bear bile powder containing bear bile powder 50g.

Embodiment 3

[0095] With embodiment 2, difference is, bear bile raw material (bear bile powder) 100g, the amount of adding beta-cyclodextrin is: 600g, adds filler: the amount of dextrin is 274g. Wet granules were prepared from the bear bile compounded medicinal materials, dried in a thermal cycle drying oven, granulated with a 20-mesh sieve, and pressed into 1000 tablets to obtain bear bile sugar-free lozenges. Each tablet weighs 1.0g and contains bear bile powder 100mg / tablet.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a bear gall sugar-free lozenge as well as a preparation method and application thereof. The bear gall sugar-free buccal tablet comprises the following components in parts by weight: 50-100 parts of a bear gall raw material, 250-600 parts of beta-cyclodextrin, 280-680 parts of dextrin, 3-8 parts of steviosin, 4-8 parts of menthol, 4-8 parts of peppermint oil, 2-4 parts of magnesium stearate, 4-8 parts of talcum powder and 3-6 parts of essence. The bear gall raw material is bear bile or bear gall powder. The bear gall is used as a main component, other appropriate auxiliary materials are preferentially matched, the prepared bear gall sugar-free lozenge is good in taste, the original components and style of the bear gall are kept, the natural physiological activity and the specific treatment effect of the bear gall are also kept, the problems of bitter taste, fishy taste and damp taste of the bear gall and the bear gall in a preparation are fundamentally solved, the quality is stable, and the traditional Chinese medicine composition is suitable for children, old people and diabetics to take.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a bear bile sugar-free buccal tablet and a preparation method and application thereof. Background technique [0002] Bear bile is the bile of black bear (Selenaretos Thibeta Cuver) or brown bear (Ursus aretos) and its processed dried bear bile powder. Bear bile powder is one of the most valuable medicinal materials in the treasure house of traditional Chinese medicine in my country, and it has been used in clinical practice for thousands of years. According to the records of "Shen Nong's Materia Medica", "Tang Materia Medica", and "Compendium of Materia Medica", bear bile is bitter in taste, cool in nature, returns to the spleen, gallbladder, heart meridian, non-toxic, and has the functions of clearing away heat, calming the liver, and improving eyesight; Convulsions and convulsions, external treatment of red eyes, swelling and pain,...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/20A23L33/10A23L29/30A23P10/28A61J3/10A61P25/08A61P27/02A61P29/00A61P11/04A61P3/06A61P9/12A61P1/16
CPCA61K35/413A61K9/0056A61K9/2059A61K9/2095A61J3/10A61P25/08A61P27/02A61P29/00A61P11/04A61P3/06A61P9/12A61P1/16A23L33/10A23L29/30A23P10/28A23V2002/00A23V2200/30
Inventor 谭养成
Owner 江西国妙堂生物医药科技有限公司
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