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Propylgallate injection and its preparing process

A technology of propyl gallate and injection, which is applied in the field of propyl gallate injection and its preparation, which can solve the problems of long freeze-drying time, high production cost, and economic burden for patients who take medication, and achieve low cost and shortened production cycle , The effect of convenient clinical use

Inactive Publication Date: 2004-03-17
吉林市卓怡康纳制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"At the same time, due to the long freeze-drying time in the production process of propyl gallate for injection, it usually takes 28-32 hours, and the power consumption of the instrument is about 1500 kWh, resulting in relatively high production costs. financial burden

Method used

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  • Propylgallate injection and its preparing process

Examples

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Comparison scheme
Effect test

Embodiment 1-4

[0145] Example 1-4: Preparation of Propylgallate Injection Small Volume Injection

[0146] The small-volume injection of propyl gallate injection contains propyl gallate, glycerin, EDTA-2Na and water for injection, and the ratio of each component is shown in Table 8. Table 8

[0147] Example 1 2 3 4

[0148] Propyl gallate (kg) 18 1 0.6 0.024

[0149] Glycerin (L) 30 10 6 3 EDTA-2Na (kg) 0.02 0.02 0.02 0.02

[0150] Add water for injection to 100L 100L 100L 100L

[0151] The preparation method is as follows:

[0152] Add 80L of water for injection into the batching tank, start the stirring paddle to stir, add glycerin and EDTA-2Na to make it completely dissolve at 75°C, then add propyl gallate, keep stirring to make it completely dissolve; add 0.1kg of activated carbon for needles, Insulate and stir at ℃ for 20 minutes, turn off the mixer, start the infusion pump, decarbonize and filter the medicinal solution through titanium rods, and put it into the dilute dispensing ta...

Embodiment 5-12

[0154] Example 5-12: Preparation of Propylgallate Injection Large Volume Injection

[0155] This propyl gallate injection large-volume injection contains propyl gallate, sodium chloride or glucose, and water for injection, and the ratio of each component is shown in Table 9. Table 9

[0156] Example 5 6 7 8 9 10 11 12

[0157]Propyl gallate (g) 24 24 36 36 72 72 180 180

[0158] Sodium chloride (g) 850 0 900 0 900 0 950 0

[0159] Glucose (g) 0 4500 0 5000 0 5000 0 5500

[0160] Add water for injection to 100L, and it can be made into different specifications such as 500, 250, 100, 50ml / bottle.

[0161] The preparation method is as follows:

[0162] Add 80L of water for injection into the batching tank, start the agitator to stir, add sodium chloride or glucose to dissolve completely at 70°C, then add propyl gallate, keep stirring to dissolve completely; add 100g of activated carbon for needles, Keep warm and stir for 25 minutes, turn off the mixer, start the infus...

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Abstract

The present invention is one kind of propyl gallate injection for treating cerebral thrombus, coronary heart disease and thrombotic deep phlebitis as surgical operation complication. The injection contains propyl gallate, medicinal supplementary material and injection water, and may be prepared into different injection preparation of different capacity. The present invention has low cost, high safety and other advantages.

Description

technical field [0001] The invention relates to a propyl gallate injection and a preparation method thereof, belonging to a pharmaceutical preparation. Background technique [0002] Propyl gallate is also known as propyl gallate (chemical name: 3,4,5-trihydroxybenzoic acid propyl ester, molecular formula: C 10 h 12 o 5 , molecular weight: 212.2), is a substance with strong antioxidant properties, and has a strong scavenging effect on superoxide anion free radicals and hydroxyl free radicals in the body. Pharmacological studies have shown that propyl gallate can inhibit TXA 2 (thromboxane A 2 ) induced platelet aggregation; it can reduce the specific viscosity of whole blood and plasma, accelerate the electrophoresis speed of red blood cells, relax vascular smooth muscle, and increase the blood flow of coronary arteries; it has obvious protective effect on myocardial ischemia. It can be used to prevent and treat cerebral thrombosis, coronary ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/216A61P7/02A61P9/10A61P9/14
Inventor 赵国华李建英
Owner 吉林市卓怡康纳制药有限公司
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