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Chinese medicinal composition for treating prostate cancer, its preparation method and its application in the preparation of medicine for treating prostate cancer

A technology of prostate cancer and composition, applied in the application field of medicine, can solve problems such as less than ideal efficiency

Inactive Publication Date: 2004-03-03
SHANGHAI ZHONGYAO BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For sex hormone-dependent prostate cancer, the effective rate of sex hormone therapy is not ideal; for non-sex hormone-dependent prostate cancer, there is no specific drug to treat it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Weigh raw materials according to the following ratio (kg)

[0093] Ganoderma lucidum 3 Scutellaria baicalensis 1 Cordyceps 1

[0094] Folium 2 Chrysanthemum 1.5 Licorice 0.5

[0095] Notoginseng 0.5

[0096] Mix the above-mentioned raw materials, grind into coarse powder of traditional Chinese medicine, divide the coarse powder into six equal parts for the following 1)-6) extraction steps;

[0097] 1) Extraction of alkaloids:

[0098] i) Diafiltering or leaching several times with 0.1% hydrochloric acid ethanol (95%) solution of the Chinese medicine coarse powder obtained above to obtain an acidic ethanol extract;

[0099] ii) concentrating under reduced pressure to obtain a concentrate;

[0100] iii) acidic water (pH=4-5) washing, in one embodiment, preferably the acidic water is frozen overnight, filtered to obtain a residue, the residue is washed with acidic water (pH=4-5) to obtain acidic water liquid;

[0101] iv) adding ammonia water to the acidic water obta...

Embodiment 2

[0122] 1) extract baicalin:

[0123] i) Add 10 times (volume) amount of water to 2 kilograms of Scutellaria baicalensis and decoct for 1 hour, filter;

[0124] ii) Adjust the filtrate to pH 2 with acid, keep it at 80°C for 30 minutes, and centrifuge to precipitate; add water and stir the precipitate evenly, add alkali to adjust the pH to neutral, then add 5 times (volume) of ethanol, and filter;

[0125] iii) Add hydrochloric acid to the filtrate, adjust the pH to 2, stir, keep at 80°C for 30 minutes, and filter;

[0126] iv) The obtained precipitate was washed with water and 50% ethanol respectively, and then washed with 95% ethanol or recrystallized to obtain baicalin.

[0127] 2) extract notoginseng saponins:

[0128]i) 40% methanol was used to extract the soluble components in 1.5 kg of Panax notoginseng coarse root powder, the methanol extract was concentrated under reduced pressure, and 5 times (volume) of water was added to the residue;

[0129] ii) The aqueous solut...

Embodiment 3

[0151] 1) extract baicalin:

[0152] i) Add 10 times (volume) amount of water to 1.5 kg of Scutellaria baicalensis and decoct for 1 hour, filter;

[0153] ii) Adjust the filtrate to pH 2 with dilute hydrochloric acid, keep it at 80°C for 30 minutes, and centrifuge to precipitate; add water and stir the precipitate evenly, add alkali to adjust the pH to neutral, then add 3 times (volume) of ethanol, and filter;

[0154] iii) Add hydrochloric acid to the filtrate, adjust the pH to 2, stir, keep at 80°C for 30 minutes, and filter;

[0155] iv) The obtained precipitate was washed with water and 50% ethanol respectively, and then washed with 95% ethanol or recrystallized to obtain baicalin.

[0156] 2) extract notoginseng saponins:

[0157] i) 40% methanol was used to extract the soluble components in 0.9 kg of root powder of Panax notoginseng, the methanol extract was concentrated under reduced pressure, and 5 times (volume) of water was added to the residue;

[0158] ii) The a...

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Abstract

A Chinese medicine for treating prostatic cancer is preapred from 7 Chinese-medicinal materials including ganoderma, chrysanthemum flower, liquorice root, notoginseng, etc through extracting their active components. Its advantages are high curative effect and low by-effect.

Description

(1) Technical field [0001] The invention relates to a traditional Chinese medicine composition for treating prostate cancer, a preparation method of the composition, and an application of the composition in preparing a medicine for treating prostate cancer. (2) Background technology [0002] Prostate cancer is one of the main causes of cancer death in men, and can be divided into two types: sex hormone-dependent and non-sex hormone-dependent. Usually only laser irradiation from the outside, radioactive material implantation or cryosurgery can be performed. For some patients, these treatments simply "lock in" the disease for a few years. Most patients will receive chemotherapy at the same time. Although it can kill cancer cells, it also seriously damages normal cells in the body, and its side effects are very serious. For the treatment of sex hormone-dependent prostate cancer with sex hormones, the effective rate is not ideal; for non-sex hormone-dependent prostate cancer, ...

Claims

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Application Information

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IPC IPC(8): A61P13/08A61P35/00
Inventor 杨亿泓
Owner SHANGHAI ZHONGYAO BIO TECH CO LTD
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