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Production method of N-benzyl glycine ethyl ester

The technology of benzyl glycine ethyl ester and glycine ethyl ester is applied in the production field of N-benzyl glycine ethyl ester, can solve the problems of complicated reaction steps, low product content and high production cost, and achieves low production cost and product yield High efficiency with few reaction steps

Inactive Publication Date: 2004-02-25
江苏优普生物化学科技股份有限公司
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  • Abstract
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Problems solved by technology

[0002] The production of N-benzylglycine ethyl ester generally adopts benzaldehyde, chlorine gas, glycine ethyl ester as main raw material in the prior art, forms through three-step reaction, and its reaction step is complicated, and generation cost is high, and product content is lower

Method used

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Embodiment 1

[0017] A production method of N-benzylglycine ethyl ester, reacting benzyl chloride and glycine ethyl ester in the presence of a catalyst and an organic solvent, adding anhydrous sodium sulfate to the reaction system, and the reaction temperature is 110-140°C, React for 6 to 12 hours to generate N-benzylglycine ethyl ester:

[0018] The catalyst is a mixture of pyridine and xylene, and the weight ratio of pyridine and xylene is 1-5:1 (eg 1:1, 3:1, 5:1). The organic solvent is toluene (or o-xylene, p-xylene, m-xylene). The weight ratio of each component consumption in the reaction system is: benzyl chloride: glycine ethyl ester=1: 1.5~3 (example 1: 1.5, 1: 2, 1: 3), the consumption of catalyzer is 5~10 of benzyl chloride consumption % (example 5%, 8%, 10%), solvent consumption is 4~10 times (example 4,6,8,10 times) of glycine ethyl ester, and the consumption of anhydrous sodium sulfate is the amount of benzyl chloride by weight. 30-150% (eg 30%, 80%, 110%, 150%).

[0019] ...

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PUM

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Abstract

The present invention discloses a production method of N-benzyl glycine ethyl ester. In the presence of catalyst and organic solvent it makes the benzyl chloride and glycine ethyl ester produce reaction to obtain N-benzyl glycine ethyl ester.

Description

Technical field: [0001] The invention relates to a production method of N-benzylglycine ethyl ester. Background technique: [0002] The production of N-benzylglycine ethyl ester in the prior art generally adopts benzaldehyde, chlorine gas, and glycine ethyl ester as main raw materials, and forms through three-step reaction, and its reaction step is complicated, and generation cost is high, and product content is lower. Invention content: [0003] The purpose of the present invention is to provide a kind of step is simple, the production method of N-benzylglycine ethyl ester that is easy to operate. [0004] Technical solution of the present invention is: [0005] A kind of production method of N-benzylglycine ethyl ester is characterized in that benzyl chloride and glycine ethyl ester are reacted to generate N-benzylglycine ethyl ester in the presence of catalyzer and organic solvent: [0006] The aforementioned catalyst is a mixture of pyridine and xylidine. [0007]...

Claims

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Application Information

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IPC IPC(8): C07C227/16C07C229/08
Inventor 秦建军曹小岗杨建明
Owner 江苏优普生物化学科技股份有限公司
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