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Lung clearing oral liquid preparation for treating viral pneumonia in Children and preparing method thereof

A technology of viral pneumonia and oral liquid, which is applied in the direction of antiviral agents, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of lack of systematic and in-depth research on effective therapies and prescriptions, lack of new drugs, etc. Achieve the effects of improving pulmonary blood circulation, advanced preparation technology, and regulating immune function

Inactive Publication Date: 2003-11-19
SICHUAN JISHENGTANG PHARMLS
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  • Abstract
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AI Technical Summary

Problems solved by technology

And the medicine that modern medicine is used for the treatment of viral infection such as ribavirin etc., curative effect is not ideal, has the report to use interferon (Zhang Xingquan. Low-dose interferon treats viral pneumonia in children. Henan Medical Information, 2002; 10( 22): 50), ribavirin (Qiu Yinping, Bian Guangbo, Ma Jinhai, etc. Observation on the curative effect of interferon, ribavirin, and Shuanghuanglian in the treatment of children with viral pneumonia. Journal of Pediatric Pharmacy, 1999; 5(1): 28~ 30) The treatment of viral pneumonia in children has achieved good curative effect, and there are many reports in various literatures
Most of these studies lack the basis of etiological diagnosis and systematic experimental research data. Although some studies are relatively comprehensive, most of them are research summaries of a single treatment method. Lack of systematic and in-depth research
Currently commonly used traditional Chinese medicines such as Zedoary Oil Glucose Injection (Jia Jingwei, Hu Jiahui. Observation of 21 Cases of Infantile Viral Pneumonia Treated with Curcuma Oil Glucose Injection. Heilongjiang Medical Science, 1999; 22 (1): 92, Chuan Huning (Huai Youwei , Song Xuefang, Zhang Gonghui, etc. Comparing the efficacy of Chuanhuning ribavirin in the treatment of children with viral pneumonia. Chinese Journal of New Drugs and Clinics, 1999; 8 (1): 55-56), etc., its mechanism of action is mainly to promote blood circulation and remove blood stasis, promote The blood circulation in the lungs is conducive to the absorption and dissipation of inflammation, but it has no obvious antiviral and other therapeutic effects; in addition, such as Fuzheng Antidrug Syrup (Julina, Li Qiuying. Fuzheng Antidrug Syrup Treats 69 Cases of Children with Viral Pneumonia. Beijing Traditional Chinese Medicine University Journal, 1995; 8(3): 50~51), Qingfei Decoction (Chen Yuqin, Shen Hongxia. Clinical observation of 263 cases of children with viral pneumonia treated with Qingfei Decoction. Henan Journal of Traditional Chinese Medicine, 2000; 15(5): 56 ~57), Weigan Wuhu Granules (Xiong Jibai. Clinical research on Weigan Wuhu Granules in the Treatment of Viral Pneumonia. Jilin Traditional Chinese Medicine, 1995; (3): 6) Although there are some studies on the therapeutic effect on viral pneumonia , but has not yet formed a new drug and is widely used in clinical practice; while the therapeutic effect of traditional Chinese medicine Houttuynia cordata injection is limited to clearing away heat and detoxification

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, composition and weight ratio of Qingfei Oral Liquid bulk drug

[0027] The composition of Qingfei oral liquid preparation raw materials and weight ratio: Ephedra (honey-roasted) 3g, bitter almond 10g, raw gypsum 20g, Tinglizi 5g, Morus alba (honey-roasted) 10g, Peucedanum 10g, silkworm (made ) 5g, Danshen 5g, Polygonum cuspidatum 12g, Boxing ginseng 12g.

[0028] If the child suffers from severe lung-heat syndrome and mild phlegm-stasis syndrome, 6g of Scutellaria baicalensis can be added to the raw material drug, and stevioside, sucrose, and potassium sorbate as auxiliary materials can be used to obtain Qingfei Oral Liquid.

Embodiment 2

[0029] Embodiment 2, the preparation method of Qingfei Oral Liquid, its preparation steps are:

[0030] (1) 10 g of bitter almonds are crushed and distilled, and its distillate is collected for subsequent use;

[0031] (2) Ephedra (honey-roasted) 3g, raw gypsum 20g, Tinglizi 5g, Morus alba (honey-roasted) 10g, Peucedanum 10g, silkworm (made) 5g, salvia miltiorrhiza 5g, Polygonum cuspidatum 12g, boxing ginseng 12g and other medicines Combine bitter almond medicinal residues and decoct with water. For the first time, measure 10 times the amount of water and decoct for 1.5 hours. For the second time, measure 8 times the amount of water and decoct for 1.0 hours. Combine the medicinal liquids for the second time and concentrate at 80°C to a relative density of 1.10. Add ethanol until the alcohol content reaches 60%, let it settle for 36 hours, filter the supernatant, recover the ethanol until it has no alcohol smell, add an appropriate amount of water, boil, refrigerate for 48 hours,...

Embodiment 3

[0040] Embodiment 3, pharmacodynamics animal experiment

[0041] (1) Experimental Study on Qingfei Oral Liquid for Cough Relief

[0042] 1. Materials

[0043] 1.1 Equipment Iron stand, screw clamp, water manometer, ammonia water container (500ml jar), animal container, waste acid container, electric suction device, perforated plastic tube, constant temperature water bath.

[0044] 1.2 Reagent 12.5%-25% ammonia water 200ml (produced by Jiangsu Baoying Chemical Reagent Factory, batch number 970615)

[0045] 1.3 The test drug Qingfei Oral Liquid (composed of Sunburned Ephedra, Bitter Almond, Gypsum, Tinglizi, Morus Alba, Peucedanum Peucedanum, Salvia Miltiorrhiza, Boxing Ginseng, Silkworm, and Polygonum cuspidatum), the concentration of each dose is 100% 90ml of oral solution. (provided by the Pharmacy Department of the First Affiliated Hospital of Nanjing University of Traditional Chinese Medicine), codeine phosphate 15mg / tablet (dissolved in water for injection to 2mg / ml)

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Abstract

A Chinese medicine "Qingfei oral liquid" for treating baby's viral pneumonitis is prepared from 10 Chinese-medicinal materials including ephedra, gypsum, bitter apricot kernel, red sage etc through grinding and distilling bitter apricot kernel to obtain liquid, decocting its dregs along with others twice, concentrating, depositing in alcohol, taking supernatant, recovering alcohol, adding water, boiling, filtering, mixing with cane sugar solution and said distilled liquid, adding water, and sterilizing. Its advantage is higher curative effect.

Description

1. Technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a compound preparation for treating children with viral pneumonia prepared by using Chinese herbal medicines as raw materials and a preparation method. 2. Background technology [0002] Pneumonia in children is a common disease in pediatrics. The World Health Organization has listed this disease as one of the three important pediatric diseases in the world, and the Chinese government has also listed it as one of the four diseases that should be prevented and controlled in pediatrics. According to reports, at present, 1 / 4 to 1 / 2 of the hospitalized cases in pediatric wards of urban hospitals are children with pneumonia, while county-level hospitals account for more than 1 / 2. According to the statistics of the World Health Organization, about 4 million children under the age of 5 die of pneumonia every year in the world, most of them are children in developing countr...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K35/64A61P11/00A61P31/12A61P33/06
Inventor 汪受传韩新民李江全任现志达庆国郭立玮刘陶世
Owner SICHUAN JISHENGTANG PHARMLS
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