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Prepn process and recipe of composite nano emulsion containing coix seed oil and java brucea fruit

A technology of javanica javanica oil and coix seed oil, which is applied in the field of medicine, can solve the problems of low safety and poor physical stability, and achieve the effect of clear action mechanism and good anticancer effect

Inactive Publication Date: 2003-09-10
SHENYANG YAODA MEDICINE DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through nano-dispersion technology, it becomes a sub-microemulsion dispersion system to overcome the shortcomings of poor physical stability and low safety in clinical use of the existing coarse dispersion system

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 (composite nanoemulsion): get 15 grams of soy lecithin, 25 grams of glycerol and the appropriate amount of water for injection preheated to 80 ℃ and mix, transfer to high-speed tissue masher, stir 3 minutes with 20000 revolutions per minute, repeat 3 times until the soybean lecithin is evenly dispersed; add 100 grams of coix seed oil and 100 grams of javanica javanica oil preheated to 80°C to the above dispersion liquid, transfer to a high-speed tissue grinder, and stir at 20,000 rpm for 3 Minutes, repeated 3 times until coix seed oil and javanica javanica oil are evenly dispersed; take the above-mentioned colostrum and add water for injection preheated to 80 ℃ to make the total volume 1000 ml, transfer to a high-pressure homogenizer, homogenize 3 times, and take samples Microscopically check until the oil droplet is below 0.5 micron; take the above-mentioned emulsion and fill it in a 50 ml infusion bottle, fill it with nitrogen, and sterilize it at 105°C fo...

Embodiment 2

[0024] Example 2 (composite microemulsion): 40 grams of poloxamer, 20 grams of sorbitol, 15 grams of soybean lecithin, 30 grams of pure glycerin and an appropriate amount of water for injection preheated to 80 ° C are dispersed and mixed with a high-speed dispersing homogenizer (2) Add 50 grams of coix seed oil and 50 grams of javanica javanica oil preheated to 80°C in the above dispersion liquid, and disperse and mix them with a high-speed dispersing homogenizer until the coix seed oil and javanica javanica oil are evenly dispersed; (3) Further disperse the above-mentioned dispersion with an ultrasonic probe, ultrasonicate for 3 minutes to obtain colostrum, add water for injection preheated to 80°C to make the full amount 1000 ml, and then ultrasonically for 3 minutes, transfer to a high-pressure nano homogenizer , homogenized 3 times.

Embodiment 3

[0025] Example 3 (compound microemulsion of coix seed oil and javanica javanica oil complex liposome): (1) get the poloxamer, sorbitol, soy lecithin and pure glycerol of the prescribed amount and preheat to 80 ℃ appropriate amount of injection Use water to disperse and mix with a high-speed dispersing homogenizer; (2) add the prescribed amount of coix seed oil and javanica javanica oil preheated to 80°C to the above dispersion liquid, and disperse and mix with a high-speed dispersing homogenizer until the coix seed Kernel oil and Brucea javanica oil are uniformly dispersed; (3) The above dispersion is further dispersed with an ultrasonic probe, ultrasonicated for 3 minutes to obtain colostrum, and water for injection preheated to 80°C is added to make the full amount, and then ultrasonicated for 3 minutes, transferred Transfer to a high-pressure nano homogenizer and homogenize 3 times.

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PUM

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Abstract

The composite nano preparation with determined anticancer effect includes coix seed oil, java, brucea fruit oil, bean phospholipid, pure glycerin and injectino water, which are prepared into composite emulsion, composite nanometer emulsion, liposome and powder for injectino for intravenous injection, oral taking, perfusion, etc. separately. Each 100 ml of the emulsion for injectino contains coix seed oil 5.0-15.0g, java brucea fruit oil 5.0-15.0 g, bean phospholipid 0.8-1.6 g and pure glycerin 2.0-3.0 g except injection water. The emulsion for injectino has grain size in the range of 0.1-0.8 micron. The coix seed oil and jave brucea fruit oil in the said preparations are extracted through supercritical SFECO2 extracting process and refined to reach the standard for injection.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a preparation process and formula of a composite nanoemulsion containing coix seed oil and javanica javanica oil. [0002] It can be prepared into an anti-tumor traditional Chinese medicine emulsion preparation, composite nanoemulsion, liposome and powder injection. The route of administration is intravenous administration, oral administration, perfusion, etc. In particular, it relates to an anti-tumor emulsion preparation prepared by extraction and compatibility of natural medicines, and also relates to the preparation method of the emulsion preparation composite nanoemulsion, liposome and powder injection. Background technique: [0003] Cancer is one of several malignant diseases that seriously endanger human health that people have not yet conquered, especially liver cancer, which is one of the diseases with the highest incidence in the world today, and kills tens of thousa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61P35/00
Inventor 唐星丁怡吴英良
Owner SHENYANG YAODA MEDICINE DEV
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