Active extracted composition of teasel root and notoginseng and use in medicine

A composition and active technology, applied to the active extract composition of Dipsacus and Panax notoginseng and its application in medicine, can solve the problems of large side effects, high price, unsatisfactory medical treatment, etc.

Inactive Publication Date: 2003-08-06
江苏省药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine mainly treats the disease with estrogen, calcium, calcitonin, bisphosphonates and fluorine preparations. Due to the high price of these drugs, long-term use of drug therapy is not satisfactory, and the side effects are large.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Dipsacus total saponins: Take 600g of Dipsacus decoction pieces, add 80% ethanol which is 7 times the weight of the medicinal materials, reflux extraction 3 times, extract for 2, 2, and 1 hour respectively, filter, combine the extracts, recover the ethanol until it is free of alcohol, And concentrated to 1g crude drug / ml aqueous solution, extracted 3 times with ethyl acetate and water-saturated n-butanol respectively, recovered n-butanol under reduced pressure until nearly dry, added a small amount of methanol to dissolve, then added ethyl acetate to the methanol solution, and precipitated Precipitate, filter, take the precipitate, dry, pulverize, and sieve through a 55-mesh sieve to obtain a yellow finished product of total saponins of Dipsacus, with a weight of 29.5 g and a content of total saponins of Dipsacus 52.2%.

Embodiment 2

[0028] Preparation of Panax notoginseng total saponins: take the Panax notoginseng medicinal material and crush it into coarse powder 300g, add 70% ethanol 8 times the weight of the medicinal material, reflux extraction 3 times, extract for 2, 2, and 1 hour respectively, filter, combine the extracts, and recover the ethanol Concentrate to 1g crude drug / ml aqueous solution until no alcohol, extract 3 times with ethyl acetate and water-saturated n-butanol, recover n-butanol under reduced pressure until nearly dry, add a small amount of methanol to dissolve, and then add acetic acid to the methanol solution Ethyl ester precipitated, filtered, took the precipitate, dried, pulverized, and sieved through a 55-mesh sieve to obtain the finished product of total saponins of Panax notoginseng with a weight of 8.5g and a content of total saponins of notoginseng of 54.5%.

Embodiment 3

[0030] Combined decoction method to prepare Dipsacus total saponins and Panax notoginseng saponins: Take 600g of Dipsacus decoction pieces and 300g of Sanqi crude powder, add 80% ethanol which is 8 times the weight of the medicinal materials, reflux extraction 3 times, extract 2, 2, 1 hour, filter, combine the extracts, reclaim ethanol until there is no alcohol, and concentrate into 1g crude drug / ml aqueous solution, extract 3 times with ethyl acetate and water-saturated n-butanol, recover n-butanol under reduced pressure to nearly dryness, add Dissolve a small amount of methanol, then add ethyl acetate to the methanol solution, precipitate the precipitate, filter, take the precipitate, dry, pulverize, and pass through a 55-mesh sieve to obtain a finished product of a mixture of khaki-colored total saponins of Dipsacus and total saponins of Panax notoginseng, with a weight of 39.3g, the total content of Dipsacus total saponins and Panax notoginseng total saponins is 50.5%.

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PUM

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Abstract

The present invention relates to a teasel and notoginseng active extract composition and its application in preparation of medicine for curing fracture and osteoporosis. Said active extract composition is formed from teasel total saponin and notoginseng total saponin with the weight ratio of 1:0.2-15, and optimum ratio of 1:0.5-5. Said invention is simple in prescription, reliable in therapeutic effect and controllable in quality.

Description

Technical field: [0001] The invention relates to an active extracting composition of Dipsacus and Panax notoginseng and its application in medicine. The extracting compositions are total saponins of Radix Dipsaceae and total saponins of Panax notoginseng. The composition can be used to prepare medicines for treating fractures and osteoporosis. Background technique: [0002] Fracture is a common injury, and the elderly and postmenopausal women suffer from rapid reduction of bone mass and increased bone fragility after osteoporosis, and fractures can occur with minor trauma. American scholars have reported that about 1 / 3 to 1 / 2 of postmenopausal women have fractures due to osteoporosis, and about 1.3 million fractures occur every year, costing about 10 billion US dollars each year. Shanghai scholars reported 10,429 elderly people over 60 years old with a fracture incidence rate of 15.6%. And after the fracture of the elderly, due to poor healing, there are many complication...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P19/08A61P19/10
Inventor 韦英杰苏国强
Owner 江苏省药物研究所有限公司
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