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Inhalant of Shumaputan dry-powder and its preparation method

A dry powder inhaler, sumatriptan technology, applied in pharmaceutical formulations, powder delivery, medical preparations containing active ingredients, etc., can solve the problems of inconvenient portability, low drug stability, waste of expensive drugs, etc.

Inactive Publication Date: 2003-05-07
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The technical problem to be solved in the present invention is to disclose a dry powder inhaler of sumatriptan and its preparation method, to overcome the low stability of the drug in the prior art, the inconvenience of carrying and using, and the need to pre-spray before use, and the device Residues in the liquid medicine, so as to cause the waste of expensive medicines

Method used

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  • Inhalant of Shumaputan dry-powder and its preparation method
  • Inhalant of Shumaputan dry-powder and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Separately pulverize 5 grams of sumatriptan, 2 grams of sodium carboxymethylcellulose, 3 grams of microcrystalline cellulose (specific name), 10 grams of diluent (lactose) and 0.1 grams of surfactant (poloxamer) Finally, pass through a 200-mesh sieve, dissolve and spray-dry at 80°C, select agglomerates that meet the particle size requirements, and quantitatively distribute them in such as figure 2 Inside the blister 1 of the double-dose blister shown, the preparation according to the invention is obtained.

Embodiment 2

[0050] 5 grams of sumatriptan, 2 grams of gel adhesive (sodium alginate), 2 grams of gel adhesive (hydroxypropyl cellulose), 2 grams of water-insoluble adhesive (chitin), 10 grams Diluent (5 grams of β-cyclodextrin, 10 grams of mannitol) is pulverized respectively, crosses 200 mesh sieves, uses 1% polysorbate 80 aqueous solution as binding agent granulation, 60 ℃ of dryings, selects and meets particle size requirement Agglomerates, add 5 grams of carrier (lactose with an angle of repose less than 40°), quantitatively dispense in such as figure 2 Inside the blister 1 of the double-dose blister shown, the preparation according to the invention is obtained.

Embodiment 3

[0052] 5 grams of sumatriptan, 2 grams of gel adhesive (hydroxypropylmethylcellulose), 1 gram of gel adhesive (starch), 2 grams of water-insoluble adhesive (methylcellulose), After 5 grams of diluent (lactose) is pulverized respectively, cross 200 mesh sieves, use 75% ethanol-water (v / v) solution as adhesive granulation, dry at 60 ℃, select the agglomerate that meets particle size requirements, add 10 grams of carrier (pregelatinized starch with an angle of repose less than 40°), quantitatively dispensed in such as figure 2 Inside the blister 1 of the double-dose blister shown, the preparation according to the invention is obtained.

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Abstract

A dried Shumaputan powder as inhalation for treating intermittent drastic headache is prepared from Shumaputan, gel adhesive, water-insoluble adhesive, diluent and surfactant.

Description

technical field [0001] The invention relates to a nasal dry powder inhaler, in particular to a sumatriptan dry powder inhaler and a preparation method thereof. Background technique [0002] Powder Inhalation (Powder Inhalation, PI) refers to a drug delivery system in which one or more drugs are administered through a special drug delivery device, and the drug enters the respiratory tract in the form of dry powder to exert systemic or local effects. Targeted, efficient, quick-acting, and less toxic and side effects. Depending on the administration site, it can be divided into nasal powder and oral (pulmonary inhalation) powder. PI can be effectively used for inhalation or inhalation administration of low-dose and high-dose drugs. The drug in the powder spray is absorbed through the abundant capillaries under the respiratory mucosa, so as a respiratory mucosa absorption preparation, it has the following characteristics: 1. No gastrointestinal degradation; 2. No liver first-p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/404A61P25/06
CPCA61K9/0043A61K31/404A61K9/0075A61P25/06
Inventor 金方
Owner SHANGHAI INST OF PHARMA IND CO LTD
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