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Rabdosia lophanthide extractive, natural medicine for treating hepatitis

A natural medicine, the technology of Xihuangcao, which is applied in the direction of drug combination, medical formula, steroidal compounds, etc., can solve the problems of interferon insensitivity, drug resistance, easy rebound, etc., achieve simple production process and improve immunity , the effect of protecting liver cells

Inactive Publication Date: 2003-03-26
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Interferon and lamivudine are currently recognized as the two types of drugs with the best anti-HBV effect, but some people are not sensitive to interferon, and the recurrence rate after application is high, the side effects are large, and the price is expensive
Lamivudine has a stronger inhibitory effect on HBV replication than interferon, but it also has disadvantages such as easy rebound after drug withdrawal, virus mutation, and drug resistance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of Xihuangcao extract (method one)

[0018] Xihuangcao (narrow base line pattern fragrant tea vegetables) dry coarse powder 4kg, reflux extraction with methanol 3 times, 2 hours each time, filter, combine the filtrate to remove methanol under reduced pressure, add appropriate amount of water to the residue (total methanol extract) , fully extracted with petroleum ether (bp60-90°C), recovered the solvent to obtain petroleum ether soluble matter and petroleum ether insoluble matter, the insoluble matter was concentrated under reduced pressure, freeze-dried to remove the solvent, and the dry extract of Xihuangcao was obtained, crushed, Pass through a 80-mesh sieve.

Embodiment 2

[0019] Embodiment 2: the preparation of Xihuangcao active extract (method two)

[0020] Xihuangcao (narrow base line pattern fragrant tea vegetables) dry product 20kg, add water, decoct twice, the first time for 2 hours, the second time for 1 hour, combine the extracts, and centrifuge at high speed (15000rpm) to remove insoluble matter. The supernatant is concentrated under reduced pressure and spray-dried to obtain the Xihuangcao extract, which is passed through an 80-mesh sieve.

Embodiment 3

[0021] Embodiment 3: the preparation of Xihuangcao active extract (method three)

[0022] Xihuangcao (narrow base line pattern fragrant tea dish) dry product coarse powder 2kg, with supercritical carbon dioxide fluid (containing 5% ethanol as entrainer), under the condition of 40 ℃, pressure 10Mpa, in supercritical carbon dioxide fluid extraction kettle Circulation extraction is carried out inside, and after extracting for 2 hours, at room temperature, adjust the temperature and pressure of the analysis kettle to 2Mpa to release carbon dioxide. The obtained extract is the supercritical carbon dioxide fluid extraction extract of Artemisia annua. Take the extract and add petroleum ether to fully degrease and decolorize. The insoluble part of petroleum ether is distilled under reduced pressure and freeze-dried to remove the solvent to obtain the extract of Xihuangcao, which is crushed and passed through an 80-mesh sieve.

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Abstract

A kind of inartificial medicine Rabdosia.serra (Maxim) Hara extraction materials which may cure hepatitis and its preparation method is disclosed in the invention, which acts Rabdosia.serra (Maxim) Hara as materials, adopts one of the hot water, supercriticality CO2 or organic impregnant extracting methods, and executes Rabdosia.serra (Maxim) Hara extracting materials by decompression condensation, vacuum dryness, spray dryness etc. methods. It contains antivirus active component 2-hydroxyl ursocic acid, 2,3-di hydroxyl ursocic acid and antioxygenation active component rosmarinic acid and so on speciality valid components, and so it has restraining HBV copy, protecting immunity liver damnification, advancing cell immunity and increasing spleen, thymus weight, bile drainage of low immunity experiment animals etc. functions.

Description

technical field [0001] The invention relates to a natural medicinal herb extract, in particular to an extract of the natural medicine Xihuangcao which can treat hepatitis. The said Xihuangcao in the present invention refers in particular to the plant whose scientific name is Isodonlophanthoides (Buch.-Ham.ex D.Don) Hara var. gerardianus (Benth.) Hara. Background technique [0002] Viral hepatitis is a major disease that threatens human health. So far, 7 types of viral hepatitis, including A, B, C, D, E, He, and G, have been found. And the most harmful with hepatitis B (HepatitisB). Hepatitis B is a worldwide disease with approximately 350 million patients worldwide. my country is a large country with hepatitis B, and hepatitis B surface antigen (HBsAg) positive people account for about 1 / 10 of the total population. In view of the fact that the persistent infection of hepatitis B virus (HBV) and the immune dysfunction of the body are the main links in the pathogenesis of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P1/16A61P31/12C07B63/00C07D307/94C07J63/00
Inventor 赖小平胡英杰陈建南朱宇同刘中秋
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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