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Antimicrobial polymeric compositions

A polymer and composition technology, applied in the field of biological inhibition and/or insecticidal applications, can solve problems such as instability, and achieve the effect of high stability and high antibacterial activity

Inactive Publication Date: 2002-05-01
CHEMEQ
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, this prior art discloses that the subject polymer has faster antimicrobial activity but is less stable in alkaline compositions than in acidic compositions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046]Water (720 ml, room temperature, ca. 20°C) and acrolein (60 g, freshly distilled, with addition of hydroquinone to 0.25% by weight) were placed in an open beaker, placed in a fume hood, and mechanically stirred vigorously . Then 0.2M aqueous sodium hydroxide solution (21.4 mL) was added to bring the pH to 10.5-11.0. The solution immediately turned into the characteristic yellow of hydroquinone anion, and the color disappeared within 1 minute, and the transparent solution turned into milky white. After about 1 minute, a white crystalline flocculent polymer precipitate appeared, which was complete within 15-30 minutes. The precipitate was filtered, washed with water (250 mL), dried on filter paper at room temperature for 2 days (yield 25 g), then spread in a thin layer in a glass Petri dish and heated at 40°C for 8 hours. This heating was continued according to the following schedule: 50°C / 15 hours; 65°C / 4 hours; 75°C / 18 hours; 84°C / 24 hours.

[0047] It is conceivable ...

Embodiment 2

[0050] Cfu / ml * (Pseudomonas aeruginosa)

[0051] * Colony forming units / ml

[0052] sample

[0053] * Colony forming units / ml

[0054] Cfu / ml * (Pseudomonas aeruginosa)

[0055] * Colony forming units / ml

Embodiment 3

[0057] (a) Similar to Example 2(a), 5% polymer solutions with apparent pH value of 5.7 and different degrees of hyperactivation were prepared, but the percentage of PEG200 was changed.

[0058] The samples were heated at 60°C and their stability was monitored throughout the time. Physical stability was considered unacceptable when precipitation or gelation occurred. UV measurements were performed in 1% sodium carbonate solution at 0.01% polymer concentration. A decrease in the ratio of absorbance at 268 nm to 230 nm is considered synonymous with a decrease in chemical stability. The results are listed in Table 4: Table 4

[0059] Both the physical results and the UV spectrum results prove that PEG has a positive effect on stability; the higher the PEG content, the higher the physical and chemical stability.

[0060] (b) Prepare the following by dissolving 4 grams of poly(2-acrolein, 2-acrylic acid) in 196 grams of 1% sodium bicarbonate, then adjusting the pH to 7 (A) and ...

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PUM

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Abstract

A method for the preparation of polymers derived from acrolein and including poly(2-propenal, 2-propenoic acid), characterised in that the polymers are exposed to the presence of water, whereby such polymers exhibit increased antimicrobial activity. The polymers may be heated in the range of 40 to 150 deg.C. Further, the polymers may be prepared in the presence of polyethylene glycols, polyols and / or alkanols.

Description

technical field [0001] The present invention relates to antimicrobial polymer compositions. More specifically, the antimicrobial polymer compositions of the present invention contain compounds having polyacrylaldehyde subunits with aldehyde groups in free form, hydrated form, hemiacetal form or acetal form and which have bioinhibitory properties and / or insecticidal properties. The invention also relates to compositions containing these polymeric compounds and to the biostatic and / or insecticidal applications of these compositions. Background technique [0002] Has been shown in the past to contain the following repeating polymer units or polymers of units in hydrated form, hemiacetal form or acetal form (hereinafter referred to as "the subject polymer") having broad-spectrum antimicrobial properties, In the formula, R is hydrogen or an alkyl group, and n is an integer of 1 or more (Nelrose et al., International Patent WO88 / 04671). The subject polymers disclosed herein ...

Claims

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Application Information

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IPC IPC(8): A01N35/02A01N37/04A01N37/42C08F8/06C08F16/34C08F16/38C08F116/34C08F116/38C08F216/34C08F216/38C08L29/00
CPCC08F216/34C08F216/38A01N37/42A01N35/02C08F220/06
Inventor G·J·H·枚罗斯G·达雷A·J·赫克斯哈姆
Owner CHEMEQ
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