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Ribavirin liposome preparation

A liposome preparation and liposome technology, applied in the field of medicine, can solve the problems of inability to bring antiviral drugs into virus-infected cells and increased toxicity

Inactive Publication Date: 2002-05-01
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antiviral preparations currently used clinically often cannot effectively bring antiviral drugs into virus-infected cells, and reach the concentration of killing the virus in the cells. If the dosage is increased, the toxicity to the human body will also increase.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] (1) Preparation

[0016] Weigh sodium dihydrogen phosphate and disodium hydrogen phosphate to prepare phosphate buffer solution, weigh 100mg / ml ribavirin crude drug and dissolve it in phosphate buffer solution, add phospholipid, cholesterol and vitamin E uniform mixture at a uniform speed, 58 ℃~62℃ for half an hour to form a homogeneous emulsion of milky white liposome microvesicles.

[0017] (2) Stability experiment

[0018] The liposome formulation has very good stability. The sample has been placed in 1992 and is still a uniform milky white emulsion without delamination and no precipitation. According to the technical requirements of new drug reporting, the stability inspection test meets the requirements, and the results of the stability test of the preparation are as follows:

[0019] Inspection items: appearance, color, decomposition (degradation) products, pH value, particle size, content, encapsulation rate, etc.

[0020] Experimental conditions: 1. Illuminat...

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Abstract

A liposome preparation of ribavirin used as an antivirus medicine is disclosed. Said liposome preparation is the artificial cells, which can carry the ribavirin into the cells infected by virus, resulting in high effect and low toxin. It is prepared through dissolving ribavirin in the buffering solution of phosphate, adding the mixture of phosphatide, cholesterin and VE, heating to 58-62 deg.C, and maintaining the temp for 30 min to obtain uniform emulsion.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular it is a ribavirin liposome preparation. technical background: [0002] The present invention is a new liposome dosage form of antiviral drug ribavirin (ribavirin, ribavirin), including all ribavirin liposomes such as injection administration, oral administration, aerosol, spray, ophthalmic and external application Plastid dosage form. This project is the achievement transformation of the National Eighth Five-Year Key Science and Technology Research Project 85-922-03-12 "Research on Liposome Preparations". [0003] Liposome is the fourth generation drug delivery system in pharmacy—a new dosage form of targeted drug delivery system. It is generally believed that ordinary injections and tablets are the first-generation drug delivery system; sustained-release preparations are the second-generation drug delivery system; controlled-release preparations are the third-generation drug de...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/7056A61P31/12
Inventor 邓英杰
Owner SHENYANG PHARMA UNIVERSITY
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