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Medicinal composition for treating elytritis, preparation and its quality control method

A composition and technology of atrophic vaginitis, applied in the direction of drug combination, test drug preparation, pharmaceutical formula, etc., can solve the problem that the disease cannot be fundamentally treated, and achieve the effect of reducing adverse reactions

Active Publication Date: 2007-03-14
LIBOYUAN MEDICINES INST BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After many years of research, we believe that atrophic vaginitis is a syndrome of deficiency in origin and excess in superficiality. It is based on kidney deficiency and damp-heat in the lower jiao is the symptom. Treating the symptoms alone can only relieve the symptoms, but cannot fundamentally treat the disease.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Get 795g of Epimedium, 530g of Fructus Cnidii, 530g of Radix Paeoniae Rubra, 530g of Cortex Phellodendri, 530g of Chonglou, 530g of Licorice, 530g of Hedyotis diffusa, 265g of Rhubarb, and make 2000 suppositories according to conventional methods.

Embodiment 2

[0131] Sunburn Epimedium 795g, Cnidium 530g, Radix Paeoniae Rubra 530g, Phellodendron 530g, Chonglou 530g, Licorice 530g, Hedyotis diffusa 530g, Rhubarb 265g, the above eight flavors, Cnidium chinensis and Epimedium reflux extraction with 70% ethanol Three times, each time for 1 hour, the amount of alcohol added is 16 times the amount of medicinal materials, the combined extracts are left to stand for 24 hours, filtered, the filtrate recovers ethanol until it has no alcohol smell, and concentrates to a relative density of 1.15-1.20 (60°C) , the liquid medicine is ready for use. Add water to decoct the remaining six flavors such as red peony root and Phellodendron phellodendron three times, each time for 1.5 hours. Make the alcohol content reach 60%, let it stand overnight, filter, recover the ethanol from the filtrate until it has no alcohol smell, concentrate to a relative density of 1.15-1.20 (60°C), combine with the above alcohol extraction liquid, and continue to concentra...

Embodiment 3

[0132] Example 3: Quality Control

[0133] Identification (1) Get 9g of the suppository obtained in Example 1, cut it into pieces, put it in a conical flask, add 40ml of ethanol, and process it ultrasonically for 30 minutes, filter, evaporate the filtrate to dryness, add 30ml of water to the residue to dissolve, extract three times with diethyl ether, 20ml each time, discard the ether solution, and then extract three times with water-saturated n-butanol, 20ml each time, combine the n-butanol solution, evaporate to dryness, add 10ml ethanol to the residue to dissolve, and use it as the test solution. Take another icariin reference substance, add ethanol to make a solution containing 0.5mg per 1ml as the reference substance solution. According to the thin-layer chromatography test, draw 4 μl of the test solution and 4 μl of the reference solution respectively on the same silica gel H thin-layer plate, and use the upper layer solution of butyl acetate-formic acid-water (1.3:1:1) ...

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PUM

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Abstract

A Chinese medicine in the form of suppository for treating atrophic vaginitis is prepared from 8 Chinese-medicinal materials including epimedium, red peony root, liquorice root, rhubarb, etc. Its preparing process and quality control method are also disclosed.

Description

field of invention [0001] The invention relates to a pharmaceutical composition, a preparation method and a quality control method thereof, in particular to a pharmaceutical composition for treating atrophic vaginitis, a preparation method and a quality control method thereof. Background technique [0002] When women begin to enter menopause, the earliest change is the decline of ovarian function and the decline of estrogen level, which will produce various clinical symptoms. In the reproductive system, the vaginal wall shrinks, the mucous membrane becomes thinner, the glycogen content in the epithelial cells decreases, the pH value in the vagina increases and the local resistance decreases, and pathogenic bacteria are easy to invade and reproduce, causing inflammation, that is, atrophic vaginitis, also known as senile vaginitis. Vaginitis. [0003] Because atrophic vaginitis is caused by the decline of estrogen level, women will face the problem of ovarian function decline...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K36/756A61K36/71A61K36/484A61K36/296A61K36/234A61K9/00A61P15/02G01N30/90G01N33/15
Inventor 黄文峰
Owner LIBOYUAN MEDICINES INST BEIJING
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