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Aderent, flexible hydrogel and medicated coatings

A coating and coating technology, used in coatings, medical containers, drug combinations, etc., can solve problems such as excessive friction, difficult substrate adhesion, uncontrollable coating lubrication and wet abrasion resistance, etc. Good tolerance, enhanced flexibility and stickiness

Inactive Publication Date: 2000-07-26
STS BIOPOLYMERS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Disadvantages of known hydrogel and medicated coatings for insertable devices include poor adhesion to inert polyolefin and metal surfaces, excessive friction, low persistence, difficult or dangerous methods of application
For polyurethane-PVP coatings, the degree of lubrication and wet wear resistance of the coating cannot be controlled, so the coating is usually unstable
PVP-cellulose ester coatings can be brittle and therefore difficult to bond to some substrates
When placed in an aqueous environment, hydrogels are capable of absorbing several times their own weight in water, causing moisture to penetrate to the coating / substrate interface and loss of adhesion, which is a serious problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Polyurethane tubing was dip-coated with the following solutions and then dried at 85°C for 45 minutes. PVP 0.289 Benzyl Alcohol 1.563 Ethanol 2.801 Cyclohexanone 5.347 Hydroxy-functional Acrylate Polymer 0.050 Xylene 0.050

[0075]Result: Use a knife to cut along the coating, then immerse the coating in water, and rub the cut vigorously with your fingers to test the viscosity of the coating. There was no loss of tack (ie, peeling back) after the wet rub test. Next, to test the dry tack of the coating, a tape of Universal Tape 83436 (United Stationers Supply, Co.) was pressed firmly on the coating and then the tape was quickly peeled off. Coatings were not removed by this test. The samples showed no loss of tack in the tape test. The coating has good lubricity when wet.

Embodiment 2

[0077] Oxygen plasma-treated polyethylene pipes were dip-coated with the following solutions and then dried at 85°C for 45 minutes. 5% (w / w) ethylene acrylic acid copolymer in THF 15.0 cyclohexanone 4.0 hydroxy-functional acrylate polymer 0.24 melamine resin 0.0680% (w / w) isocyanate polymer in THF 0.32 trichloroacetic acid 0.20

[0078] After oven drying, the samples were dip-coated with the following solutions and then dried at 80°C for 1 hour. THF 74.00 Xylene 0.25 Acrylate Copolymer with Carboxyl Function 13.88 Epoxy Resin 0.75 White Spirit 150 Solvent 9.73 Butyl Cellosolve 1.39

[0079] Next, samples were coated with the following hydrogel solutions by dipping and then dried at 80°C for 1 hour. Butyrolactone 1.80 Dimethylacetamide 1.20 Ethanol 8.75PVP 0.25THF 0.60 Xylene 0.05 Epoxy resin 0.10 Polyamide resin 0.05

[0080] Results: As evidenced by the test in Example 1, the coating exhibited good dry tack, good lubricity, and good wet rub resistance.

Embodiment 3

[0081] Embodiment 3 (contrast)

[0082] In this example, the improved coating of the present invention is compared with the PVP-cellulose ester coating of USP5,331,027, and the results show that the coating of the present invention has excellent viscosity. Silicone tubing samples were treated with oxygen plasma. The following solutions were then applied by dipping and dried at 80°C for 120 minutes. Acrylic Copolymer with Carboxyl Functionality 5.0 Petroleum Solvent 150 Solvent 3.5 Butyl Cellosolve 0.5THF 27.75 Epoxy Resin 0.56 Xylene 0.19

[0083] Next, Sample A was coated with the same hydrogel solution as used in Example 2 by dipping. Sample B was dip coated with the following solution for a control (an example of a PVP-cellulose ester formulation of USP 5,331,027) and then dried at 80°C for 2 hours. PVP 31.74 Ethanol 462.01 Butyrolactone 103.75 Cyclohexanone 12.82 Nitrocellulose 0.008

[0084] Results: The two coating samples were tested as in Example 1. Sample A, coat...

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Abstract

The adherent coating of the invention comprises a stabilizing polymer together with an active agent (a hydrophilic polymer and / or a bioactive agent) in a layer bonded to the surface of a medical device. This invention encompasses the coating liquids used for coating medical devices, methods of coating the devices, and the coated devices. The stabilizing polymer is selected to entrap the active agent in a coating that has a high degree of flexibility and has improved bonding to a wide variety of substrates. Preferred stabilizing polymers are cross-linkable acrylic and methacrylic polymers, ethylene acrylic acid copolymers, styrene acrylic copolymers, vinyl acetate polymers and copolymers, vinyl acetal polymers and copolymers, epoxy, melamine, other amino resins, phenolic polymers, copolymers thereof, and combinations.

Description

Background of the invention [0001] The present invention relates to coatings for medical devices in which active agents are embedded in stable polymers which provide improved adhesion and flexibility. The active agent can be a lubricious hydrogel-forming hydrophilic polymer, a bioactive agent that imparts a physiological effect, or a combination of both, and thus the coating can be a hydrogel and / or a drug-containing coating. [0002] Known lubricious coatings that may be used in medical devices include polyvinylpyrrolidone (PVP), polyurethane, acrylate polymers, vinyl, fluorocarbon, silicone, rubber, and certain combination coatings. US Patent 5,001,009 to Whitbourne relates to hydrophilic coatings containing PVP and cellulose ester polymers. US Patent 5,525,348 to Whitbourne discusses drug-containing polymer coatings based on cellulose esters. [0003] Disadvantages of known hydrogel and medicated coatings for insertable devices include poor adhesion to inert polyolefin an...

Claims

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Application Information

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IPC IPC(8): A61L29/00A61L27/00A61L29/08A61L29/16A61L31/00A61L31/10A61L31/16A61L33/00
CPCA61L31/16A61L31/10A61L29/085A61L2300/608A61L29/16Y10S514/834
Inventor 理查德·J·惠特伯恩张宪平
Owner STS BIOPOLYMERS
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