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Compositions and methods for inhibiting photoaging of skin

A technology of skin photoaging and composition, which is applied in the direction of skin care preparations, active ingredients of hydroxyl compounds, drug combinations, etc., and can solve minor problems

Inactive Publication Date: 2000-07-05
RGT UNIV OF MICHIGAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The patent states that starting the application of retinoids to treat photodamage from the onset of photoaging is of little significance

Method used

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  • Compositions and methods for inhibiting photoaging of skin
  • Compositions and methods for inhibiting photoaging of skin
  • Compositions and methods for inhibiting photoaging of skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Sub-erythema induction of embodiment 1--AP-1

[0073] The buttock region (ie, skin not normally exposed to sunlight) of 19 Caucasian individuals was exposed to UV radiation from the aforementioned bulb series for various periods of time, and tissue samples were taken for analysis. Such as figure 2 and 3As shown, using the aforementioned 2 minutes and 40 seconds (160 seconds) as 1 MED, different parts of the skin of these volunteers were irradiated by bulbs at 0.01, 0.05, 0.1, 0.5, 1 and 2 MED. The presence of AP-1 and the fold increase in binding to DNA encoding AP-1 were determined in biopsy skin tissue samples of irradiated skin and OMED (ie, non-irradiated) skin. As described by Angel, P. et al. in Cell (1987) 49:729-739 and Sato, H. and Seiki, M. in Oncogene (1993) 8:395-405, the production of certain MMPs is controlled by transcription Mediated by factor AP-1.

[0074] The biopsy results shown in these figures are surprising. At sub-erythematous doses of at l...

Embodiment 2

[0075] Example 2—Retinoid Prophylaxis Induced by Suberythematous Collagenase

[0076] As described in our co-pending application 588,771, supra and incorporated herein by reference, retinoids have been shown to inhibit the induction of various MMPs, including collagenase, following erythematous dose radiation.

[0077] The buttock skin of 10 volunteers was used with the same overall procedure as above, each volunteer was treated with standard vehicle (alone), vehicle with 0.1% retinoic acid (RA), or vehicle with 1% retinol (ROL) preprocessing. Tissue samples from these volunteers were biopsied after pretreatment, unirradiated, and irradiated with 0.5 MED of four bulb sets.

[0078] The results of these biopsies are shown in Figure 13B , the graph shows the fold increase in collagenase type I in 10 volunteers following the pretreatment and irradiation regimen. As shown by the results in this figure, pretreatment of human skin with retinoic acid inhibited sub-erythematous do...

Embodiment 3

[0080] Embodiment 3——The effect of external pretreatment 1 on UV irradiation

[0081] Melatonin is a hormone apparently mediated by the day-night light-dark cycle. It has recently been suggested that melatonin may function as an antioxidant.

[0082] Using much the same procedure as above, we evaluated 6 volunteers to determine the effect, if any, of topical melatonin on UV-induced erythema. Figure 9 The different UV doses and the erythema response of each of these volunteers after 5 minutes of irradiation are shown in . The previously unirradiated skin of each volunteer was pretreated with standard vehicle (alone) or vehicle with 5% melatonin. Figure 9 The results showed that erythema was induced in vehicle-treated skin but not in melatonin-treated skin after 2MED irradiation. Even if melatonin-treated skin induced erythema, it was to a significantly lower degree than in vehicle-treated and UV-irradiated skin. However, it should be kept in mind that the absence of eryth...

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Abstract

The invention provides compositions and methods for ameliorating various effects of UVA and UVB radiation from the sun. The compositions including an ingredient that prevents photoaging from MED and subMED radiation, such as a retinoid, certain other compounds (such as N-acetylcysteine, 2-furildioxime, and vitamin C) and optionally other MMP inhibitors such as tetracyclines and / or compounds that inhibit the P-450-mediated metabolism of retinoids such as ketoconazole and other azole compounds. In the method, the composition is applied prior to exposure to the sun; depending upon the ingredients used in the composition, application should be from 7 to 48 hours prior to exposure. Compounds that prevent erythema (skin reddening, sunburn) do not necessarily protect against UV-mediated elevation of MMP levels and activity, and similarly compounds that prevent UV-mediated elevation of MMP levels and activity are not necessarily effective against UV-induced erythema.

Description

technical field [0001] The present invention relates to the field of photoprotection of human skin. More particularly, the present invention relates to a topical composition and method of using the same to inhibit skin photoaging, especially photoaging that occurs daily as a result of exposure to accidental and / or direct radiation exposure. Additionally, the present invention provides novel methods and compositions for reducing UV-induced erythema (redness of the skin). Background technique [0002] The term photoaging is now used to describe changes in the appearance and / or function of human skin resulting from repeated exposure to sunlight, especially wrinkling or other changes in skin appearance. [0003] Solar radiation that reaches the Earth's surface, affects and energizes various animals (including humans) includes ultraviolet (UV) (λ<400nm), visible light (400nm<λ<700nm) and infrared light (IR) (λ>700nm). UV radiation is generally divided into UVA (320-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/00A61KA61K8/31A61K8/33A61K8/35A61K8/36A61K8/368A61K8/37A61K8/42A61K8/44A61K8/49A61K8/64A61K8/67A61K8/97A61K9/06A61K9/08A61K9/10A61K31/035A61K31/07A61K31/198A61K31/20A61K31/203A61K31/341A61K31/352A61K31/375A61K31/65A61K38/00A61P17/16A61P43/00A61Q17/04A61Q19/00A61Q19/08B60J1/00B60J3/00C03C4/08G02B5/22
CPCA61K2800/522A61K8/678A61K8/671A61K8/35A61K8/37A61K8/42A61Q19/08A61K8/676A61K8/64A61K8/447A61Q17/04A61K8/4973A61K2800/782A61K31/404A61K8/498A61K8/368A61P17/16A61P43/00
Inventor G·J·费希尔J·J·沃里斯S·康
Owner RGT UNIV OF MICHIGAN
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