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Use of mica in preparation of medicine

A technology of mica, uses, applied in pharmaceutical combinations, active ingredients of aluminum/calcium/magnesium, digestive system, etc.

Inactive Publication Date: 2006-01-18
HANGZHOU ZHEDA GASTROENTEROPATHY DIAGNOSE TECH RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Literature search shows that there is no report on the treatment of chronic atrophic gastritis with mica at home and abroad

Method used

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  • Use of mica in preparation of medicine
  • Use of mica in preparation of medicine
  • Use of mica in preparation of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Embodiment one: the prescription and technology of mica gel

[0127] The prescription is as follows:

[0128] Mica 5000g

[0129] Carbomer 2000g

[0130] Sodium bicarbonate appropriate amount (PH=6)

[0131] Chlorocresol 200g

[0132] Add water to 200L

[0133] The process is as follows:

[0134] ① Deploy 1% carbomer gel matrix: take 2kg carbomer, add 200L water, stir to dissolve, and form a transparent and uniform gel matrix

[0135] ②Preparation of 1% sodium bicarbonate solution: weigh 5g of sodium bicarbonate, add 500ml of water, stir to dissolve

[0136] ③ Preparation of chlorocresol solution: weigh 10g of chlorocresol, add 10ml of water to dissolve

[0137] ④Take the carbomer matrix and adjust the pH to 6.0 with 1% sodium bicarbonate solution

[0138] ⑤ Add mica while stirring, and stir until it becomes a uniform gel

Embodiment 2

[0139] Embodiment two: the prescription and the technology of mica powder

[0140] The prescription is as follows:

[0141] Mica 3000g

[0142] Microcrystalline Cellulose 1000g

[0143] Sorbic acid 40g

[0144] Aspartame 30g

[0145] Sweet orange essence 10g

[0146] HPMC 30g

[0147] appropriate amount of lemon yellow

[0148] The prescription is as follows:

[0149] ① Grind mica through 1000 mesh and microcrystalline cellulose through 150 mesh

[0150] ②Preparation of 3% HPMC solution: Weigh 30g of HPMC, add 1000ml of hot water, dissolve, cool to room temperature, and form a uniform transparent solution

[0151] ③ Dissolve sorbitol with proper amount of ethanol and add it to 3% HPMC solution

[0152] ④ Dissolve tartrazine with a small amount of water and add it to 3% HPMC solution

[0153] ⑤ Weigh mica, microcrystalline cellulose and aspartame according to the prescription, put in FL3-C boiling granulator, use 3% HPMC solution as binder, granulate and dry

[0154]...

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Abstract

The present invention relates to a new use of mica in preparing medicine for atrophic gastritis. By means of duplication of rat model of chronic atrophic gastritis, are observed the morphopathological, nuclear proliferation antigen and epidermal growth factor effects of mica and its positive reference medicine sucralfate. The results show that mica can reduce gastric mucosa inflammation cell infiltration and glandulose atrophy, increase the positive expression of glandulose nuclear proliferation antigen and raise the expression level of blood serum epidermal growth factor. That is to say, mica has relatively high rat chronic atrophic gastritis treating effect and certain chronic atrophic gastritis preventing and treating effect.

Description

[0001] Involved areas [0002] The present invention relates to the use of mica, in particular to the use in the pharmaceutical field. Background technique [0003] Mica is a silicate mineral drug. The main hydrous potassium aluminum silicate, its chemical molecular structure is KAl 2 Si 3 Al 10 (OH) 2 . The main components are silica and alumina. [0004] The main function of mica is mainly to invigorate the spleen, and it is mainly used for the treatment of weakness, weakness of qi, dizziness, cold malaria, chronic dysentery, chronic enteritis, externally used for carbuncle sores, gold wound bleeding embolism. However, mica is mostly used as an active ingredient in traditional Chinese medicine compound preparations for clinical use, and mica single preparations are rarely used. In the book "Mineral Drug Atlas of Traditional Chinese Medicine", there are more detailed pharmacological studies: after entering the stomach, it c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/06A61P1/04
Inventor 姒健敏王良静王海云许妙范敏华楼金芳
Owner HANGZHOU ZHEDA GASTROENTEROPATHY DIAGNOSE TECH RES DEV
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