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Coated Hypericum perforatus extract micro pill preparation and its preparing process

A technology of Hypericum perforatum and film coating, which is applied in the direction of pill delivery, sugar-coated pills, drug combination, etc., can solve instability and other problems, and achieve the effects of fast drying, improved stability, and short operation cycle

Inactive Publication Date: 2005-06-22
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The active ingredients of the obtained Hypericum perforatum extract film-coated pellet preparation have good stability, thereby overcoming the instability problem of the existing Hypericum perforatum commonly used preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The composition and proportion of the pellets are:

[0045] Blank ball core 12g

[0046] Extract A 1.8g

[0047] Extract B 0.9g

[0048] Talc powder 0.4g

[0049] Microcrystalline Cellulose 0.6g

[0050] Vitamin C 30mg

[0051] PVP 0.5g

[0052] The composition and proportion of the film coating are:

[0053] No. IV acrylic resin 0.5g

[0054] Hydroxypropyl methylcellulose 0.04g

[0055] Talc powder 0.2g

[0056] Titanium dioxide 0.2g

[0057] Magnesium stearate 0.1g

[0058] Tween-80 0.2ml

[0059] Preparation;

[0060] 1. Preparation of Hypericum perforatum extract pellets:

[0061] (1) Add 0.4 g of talcum powder, 0.6 g of microcrystalline cellulose, and 30 mg of vitamin C to 1.8 g of extract A (passed through 100 mesh), and mix well.

[0062] (2) Dissolve 0.9 g of Extract B in 2-4 ml of 10% PVP ethanol solution (filled in a spray bottle), and stir to dissolve completely.

[0063] (3) 12 grams of blank ball cores are placed in the coating pan, the rotat...

Embodiment 2

[0072] The composition and proportion of Hypericum perforatum extract pellets are the same as those in Example 1.

[0073] The composition and proportion of the film coating are:

[0074] No. IV acrylic resin 0.5g

[0075] Talc powder 0.2g

[0076] Titanium dioxide 0.2g

[0077] Magnesium stearate 0.1g

[0078] PEG60000.1g

[0079] Carmine 0.05g

[0080] Preparation Process:

[0081] 1. The preparation of Hypericum perforatum extract pellets is the same as in Example 1.

[0082] 2. Film-coat the pellets:

[0083] (1) Soak No. IV acrylic resin overnight with 95% ethanol, dissolve it, and make 5% No. IV acrylic resin solution.

[0084] (2) Dissolve 0.05g carmine completely with a few drops of water, add it to 10ml No. IV acrylic resin solution, then add 0.2g talcum powder, 0.2g titanium dioxide, 0.1g magnesium stearate and PEG6000 0.1 g. After grinding repeatedly in the grinding chamber, transfer it to a spray bottle for later use.

[0085] The remaining steps are the ...

Embodiment 3

[0087] The composition and proportion of Hypericum perforatum extract pellets are the same as those in Example 1.

[0088] The composition and proportion of the film coating are:

[0089] Hydroxypropyl methylcellulose 0.2g

[0090] Titanium dioxide 0.3g

[0091] Magnesium stearate 0.3g

[0092] Glycerin 0.12ml

[0093] Preparation Process:

[0094] 1. The preparation of Hypericum perforatum extract pellets is the same as in Example 1.

[0095] 2. Film-coat the pellets:

[0096] (1) Soak hydroxypropyl methylcellulose with 80% ethanol overnight, dissolve it, and make 2% hydroxypropyl methylcellulose solution.

[0097] (2) Add 0.3 g of 100-mesh titanium dioxide and 0.3 g of magnesium stearate in sequence to 10 ml of hydroxypropyl methylcellulose solution, then add 0.12 ml of glycerin, grind repeatedly in the grinding chamber, and transfer to a spray bottle for later use.

[0098] The remaining steps are the same as the film coating steps (3) to (5) of Example 1.

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Abstract

The invention relates to a film-coated pellet preparation of hypericum perforatum extract and a preparation process thereof. The preparation is composed of pellets containing Hypericum perforatum extract and the film coating on the outer layer; the composition ratio of the pellets is as follows: blank pellet core 180-240, extract 16-60, talcum powder 6-10, microcrystalline cellulose 10-14, vitamin C 0.4-0.8, PVP 3-28; the composition and proportion of the film coating are: No. IV acrylic resin 7.2-22 and / or 0.3-2 hydroxypropyl methylcellulose, 3-5 titanium dioxide, 1-3 magnesium stearate, 3-5 Tween-80, 1-3 PEG6000 or 1.5-3.5 glycerin. The present invention improves the heat resistance, light resistance and oxidation resistance of the preparation by selecting the type and amount of auxiliary materials and antioxidants suitable for forming Hypericum perforatum extract pellets, and screening film coating materials and coating processes that can be operated at low temperature. performance. The active ingredients of the obtained Hypericum perforatum extract film-coated pellet preparation have good stability, and overcome the instability problem of the existing Hypericum perforatum commonly used preparations.

Description

technical field [0001] The invention relates to a film-coated pellet preparation of Hypericum perforatum extract and a preparation process thereof. Background technique [0002] Pharmacological experiments in recent years have shown that Hypericum perforatm L. and its active ingredients hypericum and hyperforatin in other plants of the same genus have obvious antidepressant effects, and hypericum and hyperforatin Hypericum perforatum and (or) other plant extracts of the same genus (referred to as Hypericum perforatum extract) with content as the index have been widely used in Germany to treat moderate and mild depression. [0003] One of the biggest problems that has been perplexing the preparation of Hypericum perforatum extract is the stability of the active ingredients. The active ingredients hypericin and hypericin have a benzodianthrone structure, which is unstable to light and oxygen; hypericin is lipophilic, unstable to light, heat and air, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K9/36A61K31/122A61P25/24
Inventor 杨得坡胡海燕甘良春
Owner SUN YAT SEN UNIV
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