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Method for preparing high density core material coated with thin shell medium of agarose gel

An agarose gel, high-density technology, used in chemical instruments and methods, separation with mobile sorbents, alkali metal oxides/hydroxides, etc., can solve limited applications, alloy and metal leakage, and weakened mass transfer Efficiency and other issues, to achieve the effect of low equipment requirements, rapid separation, and good hydrophilicity

Inactive Publication Date: 2005-06-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the core-shell structure of the medium can improve mass transfer to a certain extent, the disordered particle size distribution will weaken the mass transfer efficiency
On the other hand, concerns about possible leakage of alloys and metals during the use of such media also limit their application in practical processes

Method used

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  • Method for preparing high density core material coated with thin shell medium of agarose gel
  • Method for preparing high density core material coated with thin shell medium of agarose gel
  • Method for preparing high density core material coated with thin shell medium of agarose gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016]At 90° C., 25 g of glass beads with a particle diameter of 36-143 μm were uniformly dispersed in 50 ml of 40 g / l agarose solution by rapid stirring. Then quickly pour the mixture into 300ml organic phase containing 30g / l Span 80, keep the wrapping temperature at 90°C, and control the stirring speed at 1200rpm; after stirring for 15min, quickly cool down to 15°C, and keep the stirring speed constant. Stirring was continued for 30 minutes; water twice its volume was added to the above reaction system, and high-density thin-layer microspheres were obtained by natural sedimentation. The collected microspheres were washed repeatedly with acetone and distilled water until the organic phase was washed. Get 50ml of washed microspheres (deposition weight is about 50g) and mix them with 50ml of 1mol / l NaOH, then add 500mg of sodium borohydride to make the concentration of sodium borohydride in the suspension 5g / l. The above mixture was reacted in a water bath shaker at 25° C. and...

Embodiment 2

[0018] At 90° C., 25 g of glass beads with a particle diameter of 77-307 μm were uniformly dispersed in 50 ml of 40 g / l agarose solution by rapid stirring. Then quickly pour the mixture into 300ml organic phase containing 30g / l Span80, keep the wrapping temperature at 90°C, and control the stirring speed at 1100rpm; after stirring for 15min, quickly cool down to 15°C, and continue to Stir for 30min. Add twice the volume of water to the above reaction system, and obtain high-density thin-layer microspheres by natural sedimentation. The collected microspheres were washed repeatedly with acetone and distilled water until the organic phase was washed. Then, take 50ml of washed microspheres (deposition weight is about 50g) and mix with 50ml of 1mol / l NaOH; add 500mg of sodium borohydride to make its concentration in the solution reach 5g / l; React in a water-bath shaker for 30 minutes; then add 2ml of epichlorohydrin, and react in a water-bath shaker for 5 hours at 25° C. and 170 ...

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Abstract

The invention discloses an oil-water two-phase method for preparing agarose gel thin-shell medium wrapped on the surface of high-density nuclear materials, which belongs to the microsphere preparation technology in which inert particles are loaded in a gel carrier. The method mainly includes suspension preparation, emulsification encapsulation reaction, solidification and cross-linking process, and is characterized in that glass beads are dispersed in agarose aqueous solution to form a suspension; then the suspension is added to salad oil, and Emulsifier Span 80, stirring emulsification wrapping reaction, rapid cooling to form microspheres, then adding epichlorohydrin, and cross-linking under alkaline conditions, and then reducing with sodium borohydride to make agar with a particle size of 40-500 μm A separation medium with a sugar content of 20-70%. The medium exhibits both density and particle size distribution in the expanded bed, and has high density, column efficiency and adsorption capacity. Therefore, it has broad application prospects in the expanded bed adsorption process.

Description

technical field [0001] The invention relates to an oil-water two-phase method for preparing a high-density nuclear material surface-wrapped agarose gel thin shell medium, which belongs to the microsphere preparation technology in which inert particles are loaded in a gel carrier. Background technique [0002] Expanded bed technology is a new type of integrated biological separation operation technology that gradually emerged in the early 1990s. It has the advantages of small backmixing, high void ratio, pressure drop, high column efficiency, and large processing capacity. It has been used in the separation process of biological macromolecules. been widely applied. The operating performance of expanded bed adsorption depends on whether a stable bed with low back-mixing and high column efficiency can be formed, and a stable bed is achieved by a medium with a certain density and particle size distribution. Therefore, the expanded bed adsorption t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/02B01D15/08B01J20/28B01J20/32
Inventor 孙彦周鑫史清洪白姝董晓燕
Owner TIANJIN UNIV
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