Astragalus root methyl-glycoside composition and preparation method

A technology of astragaloside IV and its composition, which is applied in the field of astragaloside IV composition and its preparation, can solve the problems of low astragaloside IV, high cost, and long cycle, and achieve the effects of good stability, clear ingredients, and small side effects

Inactive Publication Date: 2005-02-16
JIANGSU QINGJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the present invention, the traditional method has obvious deficiencies, such as low content, large solvent consumption, complex process, long cycle, high cost, and is not suitable for industrial production
[0004] Because the content of astragaloside IV in Astragalus membranaceus is very low, usually around 0.1%, it is difficult to obtain high-content astragaloside IV compositions by common methods

Method used

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  • Astragalus root methyl-glycoside composition and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Take the dried raw material of Astragalus membranaceus and cut it into 1-3mm thin slices, put it into a hot reflux extraction tank, soak it with 10 times the amount of water for 1 hour, then heat and reflux for extraction for 4 hours, release the extract, filter, and collect the filtrate.

[0041] Take HPD-100 macroporous resin, which is 1 / 2 the amount of medicinal materials, and fill the column with water wet method, wash with ethanol until the eluent is not turbid after adding water, and then wash with water until no ethanol remains. Pass the above-mentioned filtrate through the macroporous resin column. After loading the column, rinse it with water, and then use 75% ethanol to elute at a rate of 1000 ml / min. Collect the eluate and detect it at any time. Does not contain total astragalosides (usually counted as astragaloside IV), and the eluate is concentrated to dryness at 70°C under reduced pressure to obtain crude brown-yellow total astragalosides.

[0042] Dissolv...

Embodiment 2

[0044] Take the dried Astragalus raw material and cut it into thin slices of 1-3 mm, put it into a hot reflux extraction tank, soak it with 15 times the amount of water for 1 hour, then heat it for reflux extraction for 4 hours, release the extract, filter, and collect the filtrate.

[0045]Take HPD-300 macroporous resin with 1 / 2 the amount of medicinal materials, wet-pack the column with ethanol, wash with ethanol until the eluent is not turbid after adding water, and then wash with water until no ethanol remains. Pass the above-mentioned filtrate through the macroporous resin column. After the column is loaded, rinse it with water, and then use 80% ethanol to elute at a rate of 1200 ml / min. Collect the eluate, detect it at any time, and add it to the eluate Does not contain astragaloside components (usually counted as astragaloside IV), and the eluate is concentrated to dryness at 65°C under reduced pressure to obtain crude brown-yellow total astragalosides.

[0046] Dissolv...

Embodiment 3

[0048] Take the dried Astragalus raw material and cut it into thin slices of 1-3 mm, put it into a hot reflux extraction tank, soak it with 15 times the amount of water for 1 hour, then heat it for reflux extraction for 4 hours, release the extract, filter, and collect the filtrate.

[0049] Take 2 / 3 of the HPD-400 macroporous resin of the medicinal material, wet-pack the column with ethanol, wash with ethanol until the eluent is not turbid after adding water, and then wash with water until no ethanol remains. Pass the above-mentioned filtrate through a macroporous resin column. After the column is loaded, rinse it with water, and then use 90% ethanol to elute at a rate of 1500 ml / min. Collect the eluate, detect it at any time, and add it to the eluate Does not contain astragaloside components (usually counted as astragaloside IV), and the eluate is concentrated to dryness under reduced pressure at 75°C to obtain crude brown-yellow total astragalosides.

[0050] Dissolve the a...

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Abstract

The invention refers to astragaloside drug combination and the preparing method, the active component in the drug combination comes from triterpenoid saponis compound of Radix astragali, and the effective component in the compound is astragaloside IV. The method firstly uses the solvents like water to extract Radix astragali, and then makes separation and purification to obtain the coarse astragaloside, then makes hydrolyzation and recrystallization to obtain high-content astragaloside IV composition.

Description

technical field [0001] The invention relates to an astragaloside IV composition and a preparation method thereof. Background technique [0002] Astragalus is the dried root of the leguminous plant Astragalus mongolica or Astragalus membranaceus. Clinically, it is mainly used for qi deficiency and fatigue, lack of food, loose stools, depression of central qi, chronic diarrhea and prolapse of the anus, bloody metrorrhagia, spontaneous sweating due to surface deficiency, edema due to qi deficiency, and difficult ulcers. Ulceration, long-term ulceration, blood deficiency fistula yellow, internal heat and thirst, chronic nephritis proteinuria, diabetes, cardiovascular and cerebrovascular diseases, anti-virus and other diseases, the main active ingredient is triterpenoid saponins mainly composed of astragaloside IV . [0003] At present, the method for preparing total astragalus saponins is to extract astragalus with ethanol, concentrate the extract to recover ethanol completely,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P3/10A61P9/10A61P13/12C07J51/00
Inventor 余祖兵杨永安张喜全贺彦宇李东芳
Owner JIANGSU QINGJIANG PHARMA
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