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Cerium oxide nanometer nerve conduit and preparation method thereof

A nerve catheter, cerium oxide technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of catheter strength, toxicity, side effect, quality control or cost, no biomedical catheter, etc., to promote the recovery of sciatic nerve function to normal and good. Application prospect and effect of promoting nerve regeneration

Pending Publication Date: 2022-08-02
上海市第六人民医院东院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although some research progress has been made on nerve guides, such as the Chinese invention patent CN100479785C which discloses a method for preparing nerve guides, there is still a certain distance from autologous nerve repair.
In addition, there are many patents disclosing different preparation methods (such as Chinese invention patent CN101439205A, open date 2009.5.27; CN101507842A, open date 2009.8.19, CN106668938A, open date 2017.05.17; CN106924820A, open date 2017.07.07), But these catheters either have issues with strength, toxicity, quality control or cost
None of the nerve guides disclosed in the prior art are ideal biomedical guides

Method used

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  • Cerium oxide nanometer nerve conduit and preparation method thereof
  • Cerium oxide nanometer nerve conduit and preparation method thereof
  • Cerium oxide nanometer nerve conduit and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Nerve conduit biodegradable material composition

[0023] Take the polylactic acid weight ratio of 99% and the weight ratio of cerium oxide nanometers (10-1000nm) to 1%, dissolve the polylactic acid with 3 to 6 times the weight of dichloromethane, then add the cerium oxide nanometers and mix thoroughly to prepare the biodegradation of nerve conduits material composition.

Embodiment 2

[0024] Example 2 Nerve conduit biodegradable material composition

[0025] Take the polylactic acid-polyglycolic acid weight ratio of 99.5% and the cerium oxide nanoweight ratio of 0.5%, dissolve the polylactic acid-polyglycolic acid with 3 to 6 times the weight of ethyl acetate, and then add the cerium oxide nanometers and mix well to prepare the nerve cells. Catheter biodegradable material composition.

Embodiment 3

[0026] Example 3 Nerve conduit biodegradable material composition

[0027] Taking the weight ratio of polycaprolactone to 98% and the weight ratio of cerium oxide nanometer to 2%, dissolving the polycaprolactone with 3 to 6 times the weight of dichloromethane, and then adding cerium oxide nanometers and mixing thoroughly to prepare a nerve conduit biodegradable material combination.

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Abstract

The invention provides a cerium oxide nanometer nerve conduit and a preparation method thereof, and belongs to the technical field of biological materials. The cerium oxide nano nerve conduit provided by the invention is a conduit stent required by biology, has an ideal biomedical functional material, and has the advantages of simplicity in preparation, low cost, easiness in quality control, wide application and the like. Results of the embodiment show that the cerium oxide nanometer nerve conduit can significantly promote nerve regeneration.

Description

[0001] This application is a divisional application with an application date of August 14, 2018, an application number of 201810921128.X, and the title of the invention "A cerium oxide nano-nerve conduit composition, nerve conduit and its preparation method and application". technical field [0002] The invention relates to the technical field of biological materials, in particular to a cerium oxide nano-nerve conduit and a preparation method thereof. Background technique [0003] Various biomedical catheters, including degradable and non-degradable catheters, such as polyethylene tubes, have been used as nerve catheters to study nerve regeneration. Tissue fibrosis, causing inflammation and other toxic side effects, the clinical application effect is not very ideal. At present, various biodegradable materials have been developed to prepare various biomedical catheters, such as collagen, polylactic acid, etc. However, due to the use of these materials alone, there are also so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/18A61L27/02A61L27/54
CPCA61L27/025A61L27/18A61L27/54A61L27/58A61L2300/102A61L2430/32A61L2300/412C08L67/04
Inventor 欧阳元明袁伟恩范存义钱运赵笑天程媛
Owner 上海市第六人民医院东院
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