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Application of ansatriene compound in antiviral infection medicine and preparation method of ansatriene compound

A technology of ansatriene and virus infection, which is applied in the field of medicine and can solve problems such as no vaccine

Pending Publication Date: 2022-07-29
THE NAVAL MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no vaccine or specific treatment for CHIKV infection

Method used

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  • Application of ansatriene compound in antiviral infection medicine and preparation method of ansatriene compound
  • Application of ansatriene compound in antiviral infection medicine and preparation method of ansatriene compound
  • Application of ansatriene compound in antiviral infection medicine and preparation method of ansatriene compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] In the following examples, the experimental methods without specific conditions are usually in accordance with conventional conditions, or in accordance with the conditions suggested by the manufacturer. Unless otherwise specified, the reagents used in the examples of the present invention can be obtained from sales companies.

[0086] The Streptomyces flaveolus strain used in the present invention was purchased from the German Collection of Microorganisms, with the deposit number: DSM 9954.

[0087] The preparation method of ansatriene compound comprises the following steps:

[0088] Fermentation: Streptomyces flaveolus DSM 9954 strain was inoculated into seed medium (4% starch, 1% soy peptone, 2.1% malt extract, pH 7.0) for two days, and then the seed culture was inoculated into 30 liters of fermentation medium (4 % starch, 1% glucose, 2% soybean flour, pH 6.8) for fermentation, and cultured at 28° C. and 220 rpm for 7 days to obtain a fermented product.

[0089] Ex...

Embodiment 2

[0112] The in vivo and in vitro activity determination of the above-mentioned ansatriene compounds of the present invention against SARS-CoV-2 virus, tick-borne encephalitis virus, West Nile virus, yellow fever virus and chikungunya virus.

[0113] 1. Viruses, drugs, reagents and other materials

[0114] 1. Virus: The SARS-CoV-2 virus was isolated and cultured from the nasopharyngeal swab samples of COVID-19 patients by the Department of Biomedical Protection, Naval Medical University, and its gene sequence can be found in GenBank Accession No.MT622319. Tick-borne encephalitis virus and yellow fever virus were isolated and amplified by the Department of Biomedical Protection, Naval Medical University. West Nile virus and chikungunya virus were synthesized by reverse genetics and amplified from baby hamster kidney BHK cells. nourish. All experimental manipulations involving viral infection were performed in the P3 laboratory of the Naval Medical University.

[0115] 2. Compou...

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Abstract

The invention relates to the technical field of medicines, and relates to application of an ansatriene compound in preparation of medicines or pharmaceutical compositions for resisting infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), tick-borne encephalitis virus (TBEV), west nile virus (WNV), yellow fever virus (YFV) and chikungunya fever virus (CHIKV) and a preparation method of the ansatriene compound.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the preparation of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), tick-borne encephalitis virus (TBEV), Western Use and preparation method in medicine for Nile virus (WNV), yellow fever virus (YFV) and chikungunya virus (CHIKV) infection. Background technique [0002] Severe acute respiratory syndrome caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in recent years, namely COVID-19 (CoronaVirus Disease 2019, new coronavirus pneumonia), The epidemic is widespread in the world, seriously threatening the safety of human life and causing serious damage to the economy and society. The current treatment measures for COVID-19 mainly include small molecule antiviral drugs (such as protease inhibitors, polymerase inhibitors), biological macromolecular drugs (such as high titer immunoglobulins, monoclonal antibodies) and vaccines, amo...

Claims

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Application Information

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IPC IPC(8): A61K31/395A61K31/407A61K31/5383A61P31/10A61P35/00A61P31/12A61P31/14C07D491/08C07D498/04C07D225/06C12P17/10C12P17/18
CPCA61K31/395A61K31/407A61K31/5545A61K31/5383A61P31/10A61P35/00A61P31/12A61P31/14C07D491/08C07D498/04C07D225/06C12P17/10C12P17/182C12P17/188A61K2300/00
Inventor 孙鹏赵平郑旭李宏基
Owner THE NAVAL MEDICAL UNIV OF PLA
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