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Cornea repair liquid based on psychrophilic enzyme and preparation method of cornea repair liquid

A technology of psychrophilic enzyme and repairing liquid, applied in the field of corneal repairing liquid and its preparation, can solve the problems of backward concept of eye wash, wrong positioning, excessive publicity, etc., and achieve the effect of not easy drug dependence, efficient regulation of function, and reducing stimulation

Pending Publication Date: 2022-07-22
刘嘉楠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, eyewash is mainly positioned as daily eye care products. In addition to the above-mentioned problems, the survey shows that the existing eyewash market has backward concepts, wrong positioning, and excessive publicity. various issues
Moreover, there is no ophthalmic drug that uses enzymes and proteins as the main ingredient in the market at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A psychrophilic enzyme-based corneal repair fluid is prepared from the following raw materials by weight percentage:

[0038] Sodium hyaluronate 0.6%, superoxide dismutase 0.5%, glutathione peroxidase 0.5%, glutaredoxin 0.8%, glutathione 3%, vitamin E 3%, anhydrous citric acid 0.5 %, sodium citrate 1.3%, and the balance is water for injection.

[0039] A method for preparing a psychrophilic enzyme-based corneal repair solution, comprising the following steps:

[0040] (1) Weigh the raw materials:

[0041] Weigh the following raw materials according to the corresponding weight percentages:

[0042] Sodium hyaluronate, superoxide dismutase, glutathione peroxidase, glutaredoxin, glutathione, vitamin E, anhydrous citric acid, sodium citrate, water for injection;

[0043] (2) Magnetic field assisted stirring treatment:

[0044]The water for injection weighed in the step (1) is added to the stirring tank, and then the sodium hyaluronate, glutathione, vitamin E, anhydrous ...

Embodiment 2

[0048] A psychrophilic enzyme-based corneal repair fluid is prepared from the following raw materials by weight percentage:

[0049] Sodium hyaluronate 075%, superoxide dismutase 0.75%, glutathione peroxidase 0.75%, glutaredoxin 0.9%, glutathione 4%, vitamin E 6%, anhydrous citric acid 0.7 %, sodium citrate 1.7%, and the balance is water for injection.

[0050] A method for preparing a psychrophilic enzyme-based corneal repair solution, comprising the following steps:

[0051] (1) Weigh the raw materials:

[0052] Weigh the following raw materials according to the corresponding weight percentages:

[0053] Sodium hyaluronate, superoxide dismutase, glutathione peroxidase, glutaredoxin, glutathione, vitamin E, anhydrous citric acid, sodium citrate, water for injection;

[0054] (2) Magnetic field assisted stirring treatment:

[0055] The water for injection weighed in the step (1) is added to the stirring tank, and then the sodium hyaluronate, glutathione, vitamin E, anhydro...

Embodiment 3

[0059] A psychrophilic enzyme-based corneal repair fluid is prepared from the following raw materials by weight percentage:

[0060] Sodium hyaluronate 0.9%, superoxide dismutase 1%, glutathione peroxidase 1%, glutaredoxin 1%, glutathione 5%, vitamin E 9%, anhydrous citric acid 0.9 %, sodium citrate 2.1%, and the balance is water for injection.

[0061] A method for preparing a psychrophilic enzyme-based corneal repair solution, comprising the following steps:

[0062] (1) Weigh the raw materials:

[0063] Weigh the following raw materials according to the corresponding weight percentages:

[0064] Sodium hyaluronate, superoxide dismutase, glutathione peroxidase, glutaredoxin, glutathione, vitamin E, anhydrous citric acid, sodium citrate, water for injection;

[0065] (2) Magnetic field assisted stirring treatment:

[0066] The water for injection weighed in the step (1) is added to the stirring tank, and then the sodium hyaluronate, glutathione, vitamin E, anhydrous citri...

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Abstract

The invention discloses a cornea repair liquid based on psychrophilic enzyme, which is characterized by being prepared from the following raw materials: sodium hyaluronate, superoxide dismutase, glutathione peroxidase, glutaredoxin, glutathione, vitamin E, anhydrous citric acid, sodium citrate and the balance of water for injection. According to the invention, three antioxidant enzymes from Antarctic sea ice bacteria are selected, and the anti-inflammatory eye wash for removing corneal free radicals by taking a three-enzyme-one-protein component group as a core by applying the three-high advantages of high efficiency, high enzyme activity and high stability of the antioxidant enzymes. The effects of removing eye free radicals and recovering cornea healthy ecology are achieved, the trace and efficient adjusting function of biological drugs is achieved, and drug dependence is not prone to being generated. The three-enzyme-one-protein and matrix components and functional components in the cornea repair liquid are homogenized and fused in combination with a specific treatment mode to obtain a refined and homogenized product, and the absorption rate can be effectively improved in actual use, so that the utilization rate of a finished product is improved.

Description

technical field [0001] The invention belongs to the technical field of corneal repair fluid processing, and in particular relates to a psychrophilic enzyme-based corneal repair fluid and a preparation method thereof. Background technique [0002] At present, there are no ophthalmic medicines with enzymes as the main ingredient on the market. [0003] Compared with traditional eye washes, most of the eye washes with anti-inflammatory effect are added with chemical ingredients, long-term use will lead to drug dependence, and the added amount is far from the therapeutic effect, and the anti-inflammatory effect is worrying. Most of the eye washes have added preservatives, which will damage the cornea and increase the burden on the cornea. Existing products are recommended to use eye wash 3-4 times a day, far exceeding the frequency recommended by doctors. Long-term excessive use will lead to the loss of self-cleaning and adjustment capabilities of the eyes. [0004] Compared w...

Claims

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Application Information

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IPC IPC(8): A61K38/44A61K9/08A61K47/12A61P27/02A61K38/06A61K31/728A61K31/355
CPCA61K38/446C12Y115/01001A61K38/44C12Y111/01009C12Y120/04001A61K38/063A61K31/728A61K31/355A61K9/08A61K9/0048A61K47/12A61P27/02A61K2300/00
Inventor 刘嘉楠
Owner 刘嘉楠
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