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Chitosan/gelatin network support material

A scaffold material and chitosan technology, applied in the field of biomedical engineering, can solve the problems of difficult practical application and low strength, and achieve the effects of low price, good biocompatibility, and guaranteed mechanical strength

Inactive Publication Date: 2004-04-28
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Gelatin is also used as a scaffold material for tissue engineering, but its strength is too low for practical application [Kang H W, Tabata Y, Ikada Y, Fabrication of Porous Gelatin Scaffolds for Tissue Engineering, Biomaterials, 1999, 20: 1339-1344; , Hong S R, Lee YM, Song K W, Park M H, Nam Y S, Studies on Gelatin-Containing Artificial Skin: II. Preparation and Characterization of Cross-Linked Gelatin-Hyaluronate Sponge, J Biomed MaterRes (Appl Biomater), 1999, 48: 631-639]

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0007] Put 2g of chitosan and 2g of refined deacetylation degree 80% chitosan and 2g of gelatin into 80ml of 2% acetic acid aqueous solution, let stand at 40°C for 4 hours until completely dissolved, transfer the solution to a 100ml volumetric flask, add acetic acid solution , Obtain 100ml chitosan / gelatin solution (A). Take 20ml of solution (A) and transfer it to a 90mm polystyrene petri dish, and place it in a -70°C low-temperature refrigerator to pre-freeze for 24 hours; control the temperature of the drying chamber of the freeze dryer to -40°C, and move the petri dish containing the pre-frozen body into a dry Room; after temperature balance, close the drying room and turn on the air pump, keep the air pressure in the drying room less than 50 μatm Pascal and keep it for 48 hours: take it out under reduced pressure and heat it at 40°C for 2 hours, and the porous material (B) is initially obtained. Take the substrate (B) and immerse it in 10% sodium hydroxide solution and ace...

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Abstract

The present invention relates to a chitin / gelatin network scaffolding material for biomedicine and its preparation method. The chitin / gelatin porous scaffolding material prepared by using the phase separation process is cheap, good in biocompatibility, adjustable in hydrophilic and hydrophobic balancing property, suitable for attachment growth of cartilage tissue cell and requirements of different cells, and can prevent cytotoxic side-effect produced by cross-linking agent. Besides, it ensures the mechanical strength and biological (cellular) affinity of said porous material.

Description

technical field [0001] The invention belongs to biomedical engineering. technical background [0002] Tissue engineering is an emerging discipline that uses the basic principles and methods of engineering science and life science to research and develop biological substitutes to restore, maintain and improve tissue functions. The basic idea is: separate and cultivate cells in vitro, plant a certain amount of cells into a three-dimensional biomaterial scaffold with a certain shape, and continue to cultivate them, and finally form tissues and organs with a certain structure and implant them back into the body to achieve repair or repair. purpose of reconstruction. Chitosan is a natural polycationic polysaccharide (pKa=6.3). It has good biocompatibility and biodegradability, and is widely used in biomedicine, such as dialysis membrane, wound healing accelerator and drug release carrier. Medical chitosan can effectively reduce the degeneration of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/22A61L33/08
Inventor 姚康德沈锋尹玉姬成国祥
Owner TIANJIN UNIV
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