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Application of dibucaine in preparation of medicine for treating spermatogenic dysfunction

A technology of dibucaine and dysfunction, applied in the field of chemistry, to achieve the effect of increasing sperm motility

Pending Publication Date: 2022-07-05
THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report about the application of dibucaine in the preparation of drugs for the treatment of spermatogenic dysfunction

Method used

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  • Application of dibucaine in preparation of medicine for treating spermatogenic dysfunction
  • Application of dibucaine in preparation of medicine for treating spermatogenic dysfunction
  • Application of dibucaine in preparation of medicine for treating spermatogenic dysfunction

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0058] Experimental Example 1: Effects of dibucaine on spermatogenesis and sperm motility in irradiated mice

[0059] 1. Experimental materials

[0060] The experimental materials are shown in Table 1.

[0061] Table 1 Experimental materials

[0062]

[0063] 2. Experimental method

[0064] (1) Irradiation and administration: 16 mice were taken and divided into four groups with 4 mice in each group. The four groups were NC group, IR5 group, dibucaine 0.8 mg / kg group and dibucaine 0.08 mg / kg group. The mice in the IR5 group, the dibucaine 0.8 mg / kg group and the dibucaine 0.08 mg / kg group were given 5 consecutive (once a day), 0.5 Gy total body irradiation with an X-ray radiometer to construct a small group of mice. Mouse irradiation infertility model. After the model was established, the mice in the dibucaine 0.8 mg / kg group and the dibucaine 0.08 mg / kg group were treated with dibucaine for 7 consecutive times (once a day) at 0.8 mg / kg. The doses of kg and 0.08 mg / kg w...

experiment example 2

[0088] Experimental Example 2: Effects of dibucaine on spermatogenesis and sperm motility in irradiated mice

[0089] 1. Experimental materials

[0090] The experimental materials are shown in Table 1.

[0091] 2. Experimental method

[0092] (1) Irradiation and administration: 24 mice were divided into four groups with 6 mice in each group. The four groups were NC group, IR5 group, dibucaine 0.8 mg / kg group and dibucaine 0.08 mg / kg group. The mice in the IR5 group, the dibucaine 0.8 mg / kg group and the dibucaine 0.08 mg / kg group were given 5 consecutive (once a day), 0.5 Gy total body irradiation with an X-ray radiometer to construct a small group of mice. Mouse irradiation infertility model. After the model was established, the mice in the dibucaine 0.8 mg / kg group and the dibucaine 0.08 mg / kg group were treated with dibucaine for 7 consecutive times (once a day) at 0.8 mg / kg. kg, the dose of 0.08mg / kg was injected intraperitoneally. Dibucaine was dissolved in physiolog...

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Abstract

The invention relates to application of dicabaine in preparation of a medicine for treating spermatogenic dysfunction, and belongs to the technical field of medicines. The invention provides an application of dibucaine in preparation of a medicine for preventing and / or treating spermatogenic dysfunction caused by radiation, and research finds that dibucaine can significantly increase the formation number of long sperms in a spermatogenic tubule cavity of an irradiated mouse, accelerate differentiation from spermatogonium cells to spermatids of the irradiated mouse, improve the spermatogenic dysfunction of the irradiated mouse, and improve the spermatogenic dysfunction of the irradiated mouse. The compound has a great application prospect in prevention and / or treatment of spermatogenic dysfunction caused by radiation.

Description

technical field [0001] The invention relates to the application of dibucaine in the preparation of a medicine for treating spermatogenesis dysfunction, and belongs to the technical field of chemistry. Background technique [0002] The widespread application of ionizing radiation brings benefits to human beings, but also brings many risks. Studies have shown that ionizing radiation can act on the body, causing damage to biomolecules, cells and organs, and overall responses, inhibiting the spermatogenic function of the male testis, resulting in spermatogenesis dysfunction and inducing male infertility. [0003] Studies have shown that the specific damage mechanisms of ionizing radiation-induced male infertility can be divided into three categories: DNA double-strand breaks, formation of reactive oxygen species (ROS), and apoptosis. First, ionizing radiation can cause difficult-to-repair DNA double-strand breaks in spermatogenic cells, and the effect of damage increases with i...

Claims

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Application Information

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IPC IPC(8): A61K31/47A61P15/08
CPCA61K31/47A61P15/08
Inventor 刘晓龙薛波新王少雄
Owner THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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