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Traditional Chinese medicine composition for neuroprotection as well as preparation method and application of traditional Chinese medicine composition

A technology of neuroprotection and composition, which is applied in the field of neuroprotection, can solve problems such as drug effect fluctuations and switching phenomena, and achieve the effects of reducing side effects, high preventive effect, and simple and easy preparation method

Active Publication Date: 2022-05-27
国珍健康科技(北京)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the effective drug for treating Parkinson's is levodopamine preparation; however, long-term use of levodopamine drugs will cause fluctuations in drug efficacy, such as end-of-dose phenomenon, on-off phenomenon and other side effects

Method used

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  • Traditional Chinese medicine composition for neuroprotection as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for neuroprotection as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for neuroprotection as well as preparation method and application of traditional Chinese medicine composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] The PD models were treated with gastrodia elata stock solutions with concentrations of 0.5 mg / mL, 1.0 mg / mL, 2.0 mg / mL, 4.0 mg / mL, and 8.0 mg / mL, respectively, and the protection of the above concentrations of Gastrodia elata was evaluated by detecting the relative cell viability. effect. The result is as Figure 9 shown.

Embodiment 2

[0106] The PD model was treated with the stock solution of Cistanche deserticola with concentrations of 1.0 mg / mL, 2.0 mg / mL, 4.0 mg / mL, 8.0 mg / mL, and 16.0 mg / mL, respectively, and the protection of the above concentrations of Cistanche deserticola was evaluated by the detection of the relative cell viability. effect. The result is as Figure 10 shown.

Embodiment 3

[0108] PD models were treated with ginkgo stock solutions with concentrations of 0.05 mg / mL, 0.1 mg / mL, 0.2 mg / mL, 0.4 mg / mL, and 0.8 mg / mL, respectively, and the protection of ginkgo at the above concentrations was evaluated by detecting the relative cell viability. effect. The result is as Figure 11 shown.

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Abstract

The invention provides a traditional Chinese medicine composition for neuroprotection and a preparation method and application thereof, and relates to the technical field of neuroprotection. Specifically, the traditional Chinese medicine composition comprises at least two of the following components in parts by mass: 0-30 parts of cistanche, 0-20 parts of gastrodia elata, 0-10 parts of lucid ganoderma and 0-1 part of gingko. Wherein the mass parts of the cistanche and the gingko are not 0 at the same time. According to the traditional Chinese medicine composition, a Parkinson's disease cell model is protected through three action ways of resisting apoptosis, resisting oxidation and resisting inflammation, and the strong nerve protection effect is achieved through the synergistic effect of the components; and due to diversified action ways, side effects possibly caused by high-dose medication are reduced. The traditional Chinese medicine composition disclosed by the invention has a good curative effect on Parkinson's disease, and can be used for preparing novel natural component anti-Parkinson drugs; meanwhile, when the cistanche and the gastrodia elata in a limited proportion are selected to be combined, a good prevention effect can be achieved on the Alzheimer's disease.

Description

technical field [0001] The present invention relates to the technical field of neuroprotection, in particular, to a traditional Chinese medicine composition for neuroprotection and a preparation method and application thereof. Background technique [0002] Neurodegenerative disease (NDD) is a type of disease that occurs in the nervous system, causing damage or malfunction of neurons and glial cells. The world has entered an age of aging, and the harm of neurodegenerative diseases has gradually emerged. The World Health Organization predicts that by 2040, neurodegenerative diseases will replace cancer and become the second leading cause of death in human beings. Neurodegenerative diseases can be divided into acute and chronic. Among them, chronic neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, Huntington's disease and the like. [0003] Parkinson's disease (PD) is a common chronic neurodegenerative disease. The prevalence of Parkinson's disease i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61K36/64A61K36/16A61P25/16A61P25/28
CPCA61K36/64A61K36/8988A61K36/074A61K36/16A61P25/16A61P25/28A61K2300/00
Inventor 张薛勤邢岩张丽梅李永强侯思远宋双双王建成王玥李爱民李颖
Owner 国珍健康科技(北京)有限公司
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