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Preparation method of water-soluble enteric marigold lutein ester extract microcapsule particles

A technology of lutein esters and marigolds, which is applied in the direction of microcapsules, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of ester structures that are difficult to dissolve in water, have poor water solubility, and unpleasant odors and other problems, to achieve the effect of easy industrialized large-scale production, low production cost and simple process

Pending Publication Date: 2022-05-24
肇庆市佰仕科生物科技有限公司
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Problems solved by technology

Lutein ester has certain oil solubility, but its stability is poor under conditions such as acid, oxygen, heat, light, iron ions, etc. Its ester structure is extremely difficult to dissolve in water and has an unpleasant smell
However, multiple double bonds of lutein esters are conjugated to form long-chain molecules of C40, which have extremely poor water solubility and low bioavailability

Method used

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  • Preparation method of water-soluble enteric marigold lutein ester extract microcapsule particles

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Embodiment Construction

[0025] The following specific embodiments are used to illustrate the embodiments of the present invention. Those who are familiar with the technology can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the present invention. , not all examples. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0026] A preparation method of water-soluble enteric marigold lutein ester extract microcapsule particles, comprising the following steps:

[0027] Step 1: prepare a cyclodextrin mixture from α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin and hydroxypropyl-β-cyclodextrin in a ratio of 1:3:1:0.5;

[0028] Step 2: Add 10 times the mass of water to the cyclodextrin mixture, fully mix and dissolve to prepare a...

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Abstract

The embodiment of the invention discloses a preparation method of water-soluble enteric marigold lutein ester extract microcapsule particles, and particularly relates to the field of marigold lutein. By microencapsulating the marigold lutein ester extract containing lutein ester, on one hand, the water solubility of the marigold lutein ester extract is greatly improved, and the digestion and utilization rate of lutein ester is effectively improved; on the other hand, the microencapsulated marigold lutein ester extract particles can block direct contact of oxygen, heat, illumination, iron ions and the like in the air, and the stability of the lutein ester is obviously improved; meanwhile, the outer layer of the marigold lutein ester extract microencapsulated particle is coated with an enteric coating material, so that the marigold lutein ester extract microencapsulated particle is not dissolved in the stomach, and the stability of lutein ester in a gastric acid environment can be ensured; however, the marigold lutein ester extract micro-capsule particles can be completely dissolved in intestinal tracts, and the released lutein ester has good water solubility and better digestibility.

Description

technical field [0001] The embodiments of the present invention relate to the field of marigold lutein, in particular to a preparation method of water-soluble enteric marigold lutein ester extract microcapsule particles. Background technique [0002] Lutein is a natural pigment that belongs to the class of carotenoids. It has bright color, strong tinting strength, good anti-oxidation, safe and non-toxic, and has rich nutritional value. Lutein is a natural substance that widely exists in vegetables, flowers, fruits and some algae plants, and is widely used in food, health products, cosmetics, medicine, tobacco, livestock and poultry aquatic feed and other fields. In the feed industry, people mainly use lutein-containing materials as feed additives in the coloring of aquatic animals and poultry, egg yolks, skin, feathers and meat of birds. Lutein is insoluble in water and slightly soluble in oil at room temperature. Lutein has poor stability and is mainly affected by oxygen...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/23A61K36/28A61K47/69A23L33/105
CPCA61K9/5047A61K31/23A61K36/28A61K47/6951A23L33/105A23V2002/00A23V2200/30A23V2250/211A23V2250/5112Y02A50/30
Inventor 徐有良
Owner 肇庆市佰仕科生物科技有限公司
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