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Antibacterial nano-silver/lignin polyurethane dressing and one-step method for preparing dressing

A technology of lignin and nano-silver, applied in the field of biomedical materials, can solve the problems of complexity and large amount of antibacterial agent added, and achieve the effect of improving antibacterial effect, reducing toxic damage and reducing Ag content

Pending Publication Date: 2022-05-13
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is not only relatively complicated, but also the amount of antibacterial agent added is relatively large, accounting for 0.5%-3% of polyurethane by weight.

Method used

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  • Antibacterial nano-silver/lignin polyurethane dressing and one-step method for preparing dressing
  • Antibacterial nano-silver/lignin polyurethane dressing and one-step method for preparing dressing
  • Antibacterial nano-silver/lignin polyurethane dressing and one-step method for preparing dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] According to the parts by weight, weigh 30 parts of enzymatic lignin, 80 parts by weight of polyethylene glycol 400, 20 parts by weight of glycerin, and 4.5 parts of 98% sulfuric acid in a three-necked flask, mechanically stir and heat at 140°C under nitrogen protection After reacting for 1 hour, the lignin polyol was obtained by removing water, which was set aside.

[0033] According to parts by weight, take 20 parts of lignin polyols prepared above, 0.2 parts of dibutyltin dilaurate, 0.06 parts of silver nitrate aqueous solution with a concentration of 0.1mol / L as foaming agent, after stirring and mixing at 800r / min for 7min, Add 13.5 parts of hexamethylene diisocyanate and stir and mix at 12000r / min for 60s, and pour it into the mold quickly, leave it to foam at room temperature, ripen and release the mold, and obtain the antibacterial nano silver / lignin polyurethane dressing (marked as dressing 1).

[0034] The transmission electron microscope figure of the nanomet...

Embodiment 2

[0038] The difference with Example 1 is only that, this embodiment replaces 0.1mol / L silver nitrate aqueous solution with 1mol / L silver nitrate aqueous solution, obtains antibacterial nano-silver / lignin polyurethane dressing (marked as dressing 2), and this embodiment makes The transmission electron microscope image of the nano silver / lignin polyurethane dressing is shown in figure 2 As shown, the loading of nano-silver accounted for 0.01% of polyurethane.

[0039] The antibacterial nano-silver / lignin polyurethane dressing (marked as dressing 2) made in this embodiment is found through the same method test antibacterial performance as in Example 1, the bacteriostatic effect to Escherichia coli is as follows figure 2 As shown in Dressing 2, the bacteriostatic rate of Escherichia coli in Dressing 2 reached 98.6%, 99.7%, 100%, 100% in 1 hour, 2 hours, 4 hours and 8 hours; the bacteriostatic effect on Staphylococcus aureus Such as image 3 As shown in Dressing 2, the bacterios...

Embodiment 3

[0041] The difference with Example 1 is only that, this embodiment replaces 0.1mol / L silver nitrate aqueous solution with 7.5mol / L silver nitrate aqueous solution, obtains antibacterial nano-silver / lignin polyurethane dressing (marked as dressing 3), this embodiment makes The transmission electron microscope picture of the obtained nanometer silver / lignin polyurethane dressing is as follows image 3 As shown, the loading of nano-silver accounted for 0.09% of polyurethane.

[0042] The antibacterial nano-silver / lignin polyurethane dressing (marked as dressing 3) made in this embodiment is found through the same method test antibacterial performance as in Example 1, and the bacteriostatic effect of this auxiliary material 3 to Escherichia coli is as follows: figure 2 As shown in dressing 3, the antibacterial rate of auxiliary material 3 to Escherichia coli reached 99.8%, 100%, 100%, and 100% in 1 hour, 2 hours, 4 hours and 8 hours; the antibacterial effect on Staphylococcus aur...

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Abstract

The invention relates to the technical field of biomedical materials, in particular to an antibacterial nano-silver / lignin polyurethane dressing and a method for preparing the dressing through a one-step method. In the dressing, lignin is uniformly distributed in polyurethane, nano-silver is uniformly loaded on the surface of lignin polyurethane, and the loading capacity of the nano-silver is 0.001%-0.01%. The method for preparing the dressing by the one-step method comprises the step of stirring, foaming and curing the lignin polyol, the foaming agent and the diisocyanate in one step under the action of the catalyst. According to the dressing, a simple one-step method is adopted, the liquefied lignin and the foaming agent are mixed, nano-silver is obtained in the polyurethane synthesis process, the antibacterial performance of the polyurethane dressing is improved while the Ag content is reduced, the wound healing time can be shortened in the application process, and the wound healing effect is improved. And the low-content nano-silver can reduce toxic damage to normal cells of a human body, so that the safety and reliability to the human body are improved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an antibacterial nano-silver / lignin polyurethane dressing and a preparation method thereof. Background technique [0002] Lignin is an aromatic high molecular polymer with high carbon content, high thermal stability, antibacterial activity, antioxidative properties and low cytotoxicity. It is a promising natural raw material in the field of biomedicine and can be used as Antibacterial accessories. [0003] Polyurethane foam dressing has good flexibility, good moisture permeability, and low cytotoxicity. It can be used as a drug carrier, can absorb a large amount of exudate, and is almost completely permeable to oxygen and carbon dioxide. However, the preparation of polyurethane mainly relies on petrochemical products, and using natural lignin instead of petroleum resources is a feasible method to prepare environmentally friendly medical polyurethane materials. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/18A61L15/22A61L15/42A61L15/46C08G18/66C08G18/64C08G18/48C08G101/00
CPCA61L15/26A61L15/18A61L15/22A61L15/42A61L15/46C08G18/6674C08G18/4081C08G18/6492C08G18/4833C08G2101/00C08G2110/0083A61L2300/104A61L2300/404A61L2400/12A61L2300/412C08L75/04
Inventor 李淑琪陈景马晓振钟银燕王凡罗清朱锦
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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