Anti-inflammatory bactericidal amino acid hydrogel as well as preparation method and application thereof
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An amino acid and hydrogel technology, applied in medical science, bandages, etc., can solve problems such as hindering the proliferation of blood vessels and endothelial cells, and difficult wound recovery, and achieve the effects of reducing the probability of using antibiotics, saving costs, and mild and simple reaction conditions
Pending Publication Date: 2022-04-15
深圳市勇粒生物科技有限公司
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Excessive ROS content accumulates in a large amount at the wound site, causing inflammation, and hindering the proliferation of blood vessels and endothelial cells at the wound site, making it difficult to heal the wound
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Embodiment 1
[0038] A preparation method of anti-inflammatory and bactericidal amino acid hydrogel, comprising the following steps:
[0039] Step 1, providing amino acid solution and sodium alginate solution by weight percentage.
[0040] (1) Weigh 0.5 g of methionine and dissolve it in 50 ml of deionized water to form a 10 mg / mL methionine solution;
[0041] (2) Weigh 0.5 g of sodium alginate powder and dissolve it in 50 ml of deionized water to prepare a 10 mg / mL sodium alginate solution.
[0042] Step 2, mixing the amino acid solution and sodium alginate solution, and reacting under acidic atmosphere conditions.
[0043] (3) Measure 0.8mL, 0.75mL, 0.66mL, 0.5mL, 0.33mL, 0.25mL, 0.16mL, 0.14mL, 0.125mL, 0.11mL, 0.1mL of the methionine solution in step (1), Put them into 5mL transparent glass vials respectively;
[0044] (4) Measure 0.2mL, 0.25mL, 0.34mL, 0.5mL, 0.67mL, 0.75mL, 0.84mL, 0.86mL, 0.875mL, 0.89mL, 0.9mL of sodium alginate solution in step (2), respectively into each vial ...
Embodiment 2
[0054] A preparation method of anti-inflammatory and bactericidal amino acid hydrogel, comprising the following steps:
[0055] Step 1, providing amino acid solution and sodium alginate solution by weight percentage.
[0056] (1) Weigh 0.5 g of methionine and dissolve it in 50 ml of deionized water to form a 10 mg / mL methionine solution;
[0057] (2) Weigh 0.5 g of sodium alginate powder and dissolve it in 50 ml of deionized water to prepare a 10 mg / mL sodium alginate solution.
[0058] Step 2, mixing the amino acid solution and sodium alginate solution, and reacting under acidic atmosphere conditions.
[0059] (3) Weigh 0.4mL methionine solution in step (1) and 1.6mL sodium alginate solution in step (2), put them into five vials, add 20 microliters (2mg / mL) of anticancer drug curcumin respectively , photosensitizer methylene blue 20 microliters (2mg / mL), photosensitizer rose red 20 microliters (2mg / mL), photosensitizer photothermal agent indocyanine green 20 microliters (2m...
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Abstract
The invention discloses anti-inflammatory and bactericidal amino acid hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: providing an amino acid solution and a sodium alginate solution in percentage by weight; and mixing the amino acid solution and the sodium alginate solution, reacting under an acidic atmosphere condition, and soaking and cleaning with deionized water to remove residual hydrogen ions after the reaction is finished, so as to obtain the anti-inflammatory and bactericidal amino acid hydrogel. According to the anti-inflammatory and bactericidal amino acid hydrogel prepared by the preparation method disclosed by the invention, amino acid substances with antibacterial and anti-inflammatory functions are selected as raw materials, and the prepared hydrogel body has an anti-inflammatory effect under the condition of not doping any anti-inflammatory drugs, so that the probability of using antibiotic drugs is reduced, the reaction conditions are mild and simple, and the preparation method is suitable for industrial production. The preparation method has the advantages that the preparation method is simple, the preparation method is suitable for large-scale production, a physical method is adopted, toxicity is small, safety is achieved, different drugs can be doped on the premise that different use purposes need to be enhanced, the antibacterial and anti-inflammatory effects cannot be affected, and potential application prospects are achieved in the aspects of biological clinical medical patches and dressings.
Description
technical field [0001] The invention relates to the technical field of medical materials, in particular to an anti-inflammatory and bactericidal amino acid hydrogel and its preparation method and application. Background technique [0002] The inflammatory response is the body's defense mechanism against infection, injury and toxins. Inflammation is a common clinical disease, and these inflammatory disease sites usually produce a large number of inflammatory markers, lipid peroxides, and free radicals. In particular, reactive oxygen species (ROS) are overexpressed at these inflammatory sites, and ROS are composed of various oxidative molecules, including hydrogen peroxide (H 2 o 2 ), singlet oxygen ( 1 o 2 ), superoxide anion (O 2 -) and hydroxyl radicals (·OH), etc. Excessive ROS content accumulates in a large amount at the wound site and causes inflammation, and hinders the proliferation of blood vessels and endothelial cells at the wound site, making it difficult to ...
Claims
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