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Application of icariin in the preparation of medicine for treating anemia

A technology of icariin and anemia, which is applied in the field of medicine, can solve problems such as unsatisfactory effects, low drug compliance rate, and long treatment time, and achieve increased red blood cell count and hemoglobin value, and low side effects and adverse reaction rates , the effect of high medication compliance

Active Publication Date: 2019-12-31
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In order to overcome the deficiencies in the prior art such as the relatively long treatment time and unsatisfactory effect of diet therapy to correct anemia, and the current commonly used anemia treatment drugs are expensive and the drug compliance rate is low, the present invention discloses that icarigenin is used in the preparation and treatment of The use in anemia medicine, the treatment medicine uses icariin as the main active ingredient, and after being prepared into a pharmaceutical preparation, it has obvious therapeutic effects on various types of anemia, and has the advantages of clear ingredients, low treatment cost, and high medication compliance , so it has broad medical application prospects

Method used

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  • Application of icariin in the preparation of medicine for treating anemia
  • Application of icariin in the preparation of medicine for treating anemia
  • Application of icariin in the preparation of medicine for treating anemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 icarigenin microemulsion preparation

[0033]

[0034] Preparation process: Weigh the prescription amount of hydrogenated cocoglyceride, lauroyl polyethylene glycol-32-glyceride, 1,2-propylene glycol, polyethylene glycol 3350, mix and stir evenly, then add icariin to dissolve , Ultrasonic treatment to accelerate the dissolution, to obtain a clear concentrate, which is the icarigenin microemulsion concentrate. The microemulsion concentrate obtained above is diluted with water according to the weight ratio of 1:10-20 to a clear solution to obtain the microemulsion. The particle size was measured by a laser particle size analyzer, and the average particle size was 40nm.

Embodiment 2

[0035] Example 2 Icarigenin enteric-coated soft capsule preparation

[0036] Contents Prescription:

[0037]

[0038] Rubber prescription:

[0039]

[0040] Enteric coating solution prescription:

[0041]

[0042] Preparation process: Weigh the prescription amount of medium-chain fatty acid glycerides, polyoxyethylene castor oil, propylene glycol, and absolute ethanol, mix and stir evenly, then add icarigenin to dissolve, or use ultrasonic treatment to speed up the dissolution, and obtain clarification and concentration The liquid is the icariin microemulsion concentrate. Dilute the microemulsion concentrate obtained above with water at a weight ratio of 1:10-20 to a clear solution to obtain the microemulsion content. Weigh the gelatin, glycerin, and purified water in the prescription amount, mix them evenly, and press them into rubber, then weigh Eudragit L30D-55, triethyl citrate, talcum powder, and purified water in the recipe amount, and mix them evenly to make...

Embodiment 3

[0043] Example 3 Icarigenin Oral Liquid

[0044]

[0045] Preparation process: Place the prescribed amount of methylparaben and ethanol in a suitable container, add the prescribed amount of icariin, heat it in a water bath to dissolve, then dissolve the prescribed amount of sodium benzoate, essence, and sucrose with a small amount of water Finally, add it to the above-mentioned drug-containing mixed solution, add water to the full amount, stir evenly, filter, pack and sterilize.

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Abstract

The invention relates to an application of anhydroicaritin in preparation of medicine for treating anaemia, which belongs to the medicine field. The application of anhydroicaritin in preparation of medicine for treating anaemia solves the technical disadvantages of poor treatment effect of the current medicines and high price of the medicines. The invention also provides a medicine for treating anaemia by taking anhydroicaritin as active component. The pharmacological experiment displays that the anhydroicaritin has active treatment effect for aplastic anemia, anemia of inflammation, hemolytic anaemia, renal anemia or its combination. The anhydroicaritin for treating anaemia has the advantages of clear effect mechanism, clear composition, definite therapeutic effect and wide medical science application prospect.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new medical application of icariin, in particular to the application of icariin in the preparation of medicine for treating anemia. Background technique [0002] Anemia refers to that the human hemoglobin level is lower than 10-l2g / dL or the number of circulating red blood cells is reduced, resulting in "hunger" in aerobic tissues and organs, which makes patients prone to fatigue and decreased overall quality of life. If severe cases are not treated It may also be life-threatening. Chinese hematologists believe that in my country's sea-level areas, adult male Hb<120g / L, adult female (non-pregnant) Hb<110g / L, and pregnant woman's Hb<100g / L are anemia. According to the statistics of the World Health Organization: there are about 3 billion people with varying degrees of anemia in the world, and tens of millions of people die every year due to various diseases caused by anemia. The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P7/06A61P13/12
Inventor 赵志全徐真真孙成宏牟丽丽
Owner LUNAN PHARMA GROUP CORPORATION
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