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Filler composition, injection comprising same, and method for injecting same

A technology of composition and injection, which is applied in the field of filler composition for oral tissue repair, can solve the problems of low success rate, unsightly appearance, and insufficient, etc., and achieve the effects of increasing the use time, optimizing bone configuration, and promoting bone formation

Pending Publication Date: 2022-04-15
孙珍炅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, the problem with this filler composition that has been mainly used in the face in the past is that it cannot solve the problem caused by the insufficient volume or area of ​​the gum in the patient's oral cavity, that is, it cannot solve the problem of gum recession or various prosthetic treatments. Unsightly and inconvenient prosthesis due to insufficient soft tissue, hyperesthesia due to root exposure, unsightly gingival discoloration, unsightly prosthesis due to gingival recession between teeth, etc.
In addition, when a black triangle occurs in the space between two teeth due to gingival recession, even if a very delicate periodontal surgery is performed by transplanting gingival tissue from the palate or other parts to the receding part for fixation, after 4- The healing period is 8 weeks, the success rate is not high, and it must be performed by a skilled doctor, but in fact, even if a dental prosthesis is made to seal the empty space or a prosthesis deformed to the color of the gums, it is very unsightly , high patient dissatisfaction
[0014] That is, no suitable dental filling composition has been developed in the past. In the case of dental implant surgery, there are many problems such as unsightly appearance due to insufficient soft tissue, space left between implants or between teeth and implants, etc. question

Method used

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  • Filler composition, injection comprising same, and method for injecting same
  • Filler composition, injection comprising same, and method for injecting same
  • Filler composition, injection comprising same, and method for injecting same

Examples

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experiment example

[0113] In order to confirm the effect of the concentration change of hyaluronic acid (comparative example) and hyaluronic acid-polydeoxyribonucleotide (example) on the viability (proliferation rate) of human fibroblasts (HS68), 2% hyaluronic acid The acid solution was diluted in Dulbecco's modified Eagle's medium (supplemented with 1% (v / v) penicillin / streptomycin (Lonza, USA) and 10% (v / v) Fetal bovine serum (Lonza, New Jersey, U.S.) Dulbecco's (S) modified Eagle (S) medium (Korea Welgene (Welgene) company)), respectively prepared into 0.005, 0.01, 0.02, 0.05, 0.1, 0.2, 0.5% (v / v) concentrations, 2% (v / v) hyaluronic acid-polydeoxyribonucleotides were also diluted to the same concentrations as above. Cells were divided into 96-well plates (SPL Life Sciences, Korea) at a density of 5000 cells / cm2. For cell attachment, after culturing the cells for 24 hours, the medium was removed and 100ul was added to each well. Diluted hyaluronic acid and hyaluronic acid-polydeoxyribonucleot...

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Abstract

The invention discloses a filler composition, an injection containing the filler composition and a method for injecting the filler composition. The present invention relates to a filler composition that makes it possible to repair collapsed sites in the oral cavity, including periodontium of gums and soft tissue sites such as the lips. One form of the filler composition of the present invention may be composed of hyaluronic acid and at least one of fibrin glue, growth factor, collagen, and calcium.

Description

technical field [0001] The present invention relates to filler compositions. Specifically, the present invention relates to a filler composition for oral tissue repair that enables repair of collapsed parts of soft tissue parts in the oral cavity including periodontal gums and lips. Background technique [0002] Generally speaking, the environment in the oral cavity is completely different from other facial tissues, and is always in a moist state due to saliva and food. In saliva, there are microorganisms such as various bacteria and molds produced by ingesting food, food residues, tartar, plaque, tongue coating, inflammatory cells, minerals, etc. Dental treatment is different for each patient, so it is Special body parts where various dental materials (titanium, gold alloys, other metal alloys, amalgam, resins, zirconia, ceramics, etc.) coexist. [0003] In addition, unlike other facial parts, oral soft tissue has unique properties that are different from other human tiss...

Claims

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Application Information

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IPC IPC(8): A61K6/898A61K6/80A61K6/69A61K38/18A61K9/00A61K47/36A61P1/02A61P29/00A61K31/711
CPCA61L27/20A61L27/24A61L27/54A61C8/0083A61L2430/12A61L2430/34A61L2300/402A61L2400/06A61L2300/41A61L2300/442
Inventor 孙珍炅
Owner 孙珍炅
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