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Preparation method of isomerized lactose

A technology of isomerization and lactose, applied in the field of preparation of isomerized lactose, can solve the problems of dark color, low yield and purity of lactulose, poor product quality, etc., and achieves simple analysis, continuous production process, and reduced chromaticity. cumulative effect of

Pending Publication Date: 2022-04-12
SHANDONG BAILONG CHUANGYUAN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the lactulose prepared by the above method generally has the disadvantages of low lactulose yield and purity, poor product quality, darker color, etc.

Method used

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  • Preparation method of isomerized lactose
  • Preparation method of isomerized lactose
  • Preparation method of isomerized lactose

Examples

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Effect test

Embodiment 1

[0039] A method for preparing isomerized lactose, comprising the following steps:

[0040] (1) Take lactose and dissolve it with water to obtain a lactose solution with a mass concentration of 40 wt%, then add activated carbon of 1% lactose on a dry basis in the lactose solution, stir for 30 minutes at a temperature of 70°C, press filter, and decolorize and filter the lactose The feed liquid passes through the positive column-negative column-positive column at 40°C at a flow rate of 3 times the volume of the resin per hour to carry out separation and desalination to remove protein, pigment, etc. in the lactose; The ratio is 1:1, add boric acid to the lactose feed solution obtained from the separation, add sodium hydroxide to adjust the pH of the system to 10-11, and then carry out isomerization reaction at 80°C for 3 hours to obtain isomerized lactose feed liquid.

[0041] The components of the isomerized lactose feed solution obtained by isomerization were detected by high p...

Embodiment 2

[0049] A method for preparing isomerized lactose, comprising the following steps:

[0050] (1) Take lactose and dissolve it with water to obtain a lactose solution with a mass concentration of 40 wt%, then add activated carbon of 1% lactose on a dry basis in the lactose solution, stir for 30 minutes at a temperature of 70°C, press filter, and decolorize and filter the lactose The feed liquid passes through the positive column-negative column-positive column at 40°C at a flow rate of 3 times the volume of the resin per hour to carry out separation and desalination to remove protein, pigment, etc. in the lactose; The ratio is 0.5:1, add boric acid to the lactose feed solution obtained from the separation, add sodium hydroxide to adjust the pH of the system to 10-11, and then carry out isomerization reaction at 80°C for 3 hours to obtain isomerized lactose feed liquid.

[0051] High performance liquid chromatography was used to detect the components of the isomerized lactose fee...

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Abstract

The invention provides a preparation method of isomerized lactose, which comprises the following steps: (1) isomerization: preparing a lactose solution, carrying out decoloration and ion exchange treatment on the lactose solution, adding boric acid, regulating the pH value of the system to 10-11 by using sodium hydroxide, and carrying out isomerization reaction to obtain an isomerized lactose feed liquid; (2) carrying out decoloration treatment: carrying out decoloration treatment on the isomerized lactose feed liquid by adopting granular active carbon; (3) carrying out chromatographic desalination and purification treatment: carrying out desalination and purification treatment on the decolorized isomerized lactose feed liquid by adopting simulated moving bed chromatography; (4) carrying out boron removal treatment on the desalted isomerized lactose feed liquid by using macroporous adsorption resin; and finally, carrying out decoloration, ion exchange and vacuum concentration to prepare high-purity isomerized lactose liquid. The method disclosed by the invention is simple in operation process and easy for industrial production, and the obtained isomerized lactose product is relatively high in quality, relatively light in color and high in purity.

Description

technical field [0001] The invention relates to a method for preparing isomerized lactose, which belongs to the technical field of preparation of functional sugar products. Background technique [0002] Isomerized lactose, also known as lactulose, chemical name 4-O-β-D-galactopyranosyl-D-fructose, molecular weight 342.297, is isomers with lactose, its finished product is light yellow transparent viscous Thick liquid, sweet taste, its crystals are white irregular powder, relative density 1.5, melting point 169°C, easily soluble in water, solubility 76.4±1.4%. Its sweetness is equivalent to that of lactose is less than sucrose, about 48% to 60% of sucrose, with a cool and mellow feeling, low viscosity, low calorific value, high safety, good stability, and no Maillard reaction. [0003] At present, the main method of industrial production of lactulose is to use NaOH and boric acid as the catalytic system of alkali isomerization to prepare lactulose. Under alkaline conditions,...

Claims

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Application Information

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IPC IPC(8): C07H1/00C07H1/06C07H3/04
Inventor 禚洪建张明站杨腾腾张兴晶刘双双刘国清
Owner SHANDONG BAILONG CHUANGYUAN BIO TECH
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