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Florfenicol soluble powder and preparation method thereof

A florfenicol and soluble technology, which is applied in the field of florfenicol soluble powder and its preparation, can solve the problems of inability to maximize the solubility of florfenicol, insufficient contact of particles of raw and auxiliary materials, and discounted inclusion effect. To achieve the effect of improving bioavailability, improving inclusion effect and improving efficiency

Pending Publication Date: 2022-04-08
ZHEJIANG WANFANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can effectively improve the solubility of Florfenicol, but the use of a large amount of methanol or ethanol in the formula leads to high product costs and a large risk factor in the large-scale production process, which has certain limitations
Another example is that the patent with application number CN201510800663.6 adopts a simple mixing and pulverizing method instead of a dissolution and inclusion method in the production process. The particle size of the pure mixing and pulverizing particles will not be lower than 5 μm, resulting in insufficient contact between the particles of raw and auxiliary materials. , the inclusion effect is greatly reduced, and the solubility of Florfenicol cannot be maximized

Method used

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  • Florfenicol soluble powder and preparation method thereof
  • Florfenicol soluble powder and preparation method thereof
  • Florfenicol soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A florfenicol soluble powder, the composition of every 100g product is: florfenicol 20g, beta cyclodextrin 74.3g, poloxamer F68 0.5g, glycerin formal 3g, glycerol triacetate 2g, ten Dialkyl sodium sulfate 0.2g.

[0035] The method for preparing above-mentioned Florfenicol soluble powder, its steps are as follows:

[0036] S1. Accurately weigh 20 g of florfenicol, 74.3 g of beta-cyclodextrin, 0.5 g of poloxamer F68, 3 g of glycerol formal, 2 g of glycerol triacetate, and 0.2 g of sodium lauryl sulfate, and set aside;

[0037] S2, first mix florfenicol and beta-cyclodextrin evenly, then pulverize in the airflow mill, the airflow mill includes a body 1, a hopper 2, and a high-pressure airflow input port 3, and the high-pressure airflow input port is provided with 3 settings On one side of the body 1, the other side of the body 1 is also provided with a discharge port 4, the hopper 2 is fixedly installed on the top of the side of the body 1 provided with the high-pressure ...

Embodiment 2

[0041] A florfenicol soluble powder, the composition of every 100g product is: florfenicol 20g, beta-cyclodextrin 73.7g, poloxamer F127 1.0g, glycerin formal 3.5g, triton X-100 1.5g, sodium lauryl sulfate 0.3g.

[0042]The method for preparing above-mentioned Florfenicol soluble powder, its steps are as follows:

[0043] S1. Accurately weigh 20g of florfenicol, 73.7g of beta-cyclodextrin, 1.0g of poloxamer F127, 3.5g of glycerin formal, 1.5g of triton X-100, 0.3g of sodium lauryl sulfate ,spare;

[0044] S2. First mix florfenicol and beta-cyclodextrin evenly, then pulverize in a jet mill, the air pressure is 1.3Mpa, the particle size of the detected particle is in the range of D90=5μm, and the solubility of the micropowder is 1200ppm or above;

[0045] S3. Stir Triton X-100 and glycerin formal in hot water at 40-45°C to dissolve and clarify, put into the ultrafine pulverized clathrate obtained in S2, stir to dissolve and clarify, and then add Poloxamer F127 and Sodium laury...

Embodiment 3

[0048] A florfenicol soluble powder, the composition of every 100g product is: florfenicol 20g, beta cyclodextrin 74.7g, xylooligosaccharide 0.7g, xanthan gum 0.3g, triton X-100 0.5 g, 3.5 g of triacetin, 0.1 g of sodium dodecylbenzenesulfonate, and 0.2 g of sodium xylenesulfonate. When xylooligosaccharide and xanthan gum are used at a ratio of 7:3, the suspension of the product can be better improved, and it can help to achieve a higher degree of dispersion when dissolved in water.

[0049] The method for preparing above-mentioned Florfenicol soluble powder, its steps are as follows:

[0050] S1. Accurately weigh 20g of florfenicol, 74.7g of beta-cyclodextrin, 1.0g of poloxamer F127, 0.5g of triton X-1000, 3.5g of triacetin, sodium dodecylbenzenesulfonate 0.1g, sodium xylene sulfonate 0.2g, for subsequent use;

[0051] S2. First mix florfenicol and beta-cyclodextrin evenly, then pulverize in a jet mill, the air pressure is 1.3Mpa, the particle size of the detected particle ...

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Abstract

The invention discloses florfenicol soluble powder. Every 100 parts by weight of the florfenicol soluble powder contains 10 to 20 parts of florfenicol, 73 to 86.3 parts of an inclusion agent, 0.5 to 1.5 parts of a suspending aid, 3 to 5 parts of a solubilizer and 0.2 to 0.5 part of a wetting agent. According to the florfenicol soluble powder disclosed by the invention, through a superfine grinding and dissolving two-step inclusion technology, the inclusion efficiency between a subject and an object is powerfully improved, and the solubility of florfenicol in water is further improved, so that the bioavailability of a product is effectively improved, cost reduction and efficiency improvement in the clinical use process of a medicine are facilitated, and the clinical application prospect is wide. The use amount of antibiotics is reduced, so that culture benefits are improved.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparations, in particular to a florfenicol soluble powder and a preparation method thereof. Background technique [0002] Florfenicol is a chemically modified chloramphenicol broad-spectrum veterinary antibiotic, also known as florfenicol, which has good antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, and is widely used in pigs, Treatment of respiratory diseases in chickens, cattle, sheep and other animals. Florfenicol was successfully developed by Schering-Plough in the 1970s, and its chemical formula is C 12 h 14 C 12 NO 4 SF is an odorless white to off-white crystalline powder, almost insoluble in water. From a structural point of view, Florfenicol replaces the nitro group on the structure of chloramphenicol with a methylsulfonic group to eliminate the damage of chloramphenicol to the bone marrow hematopoietic function, and replaces the hydroxyl ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/165A61K47/69A61K47/24A61K47/14A61P31/04
Inventor 刘金松杨彪吴亚坤郗洪生
Owner ZHEJIANG WANFANG BIO TECH CO LTD
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