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Florfenicol soluble powder and preparation method thereof

A florfenicol and soluble technology, which is applied in the field of florfenicol soluble powder and its preparation, can solve the problems of difficult absorption in the digestive tract, uneven dispersion, and affecting solubility, etc., and achieves good quick release effect and high solubility Good, good stability

Active Publication Date: 2022-03-22
ZHEJIANG LANGBO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although the solubility of florfenicol has been improved to a certain extent by adding co-solvents, making florfenicol into ultrafine powder or adopting technologies such as β-cyclodextrin inclusion, it is not really water-soluble ( Clear and transparent), thus causing another problem affecting solubility, that is, when the powder is mixed with a fluid (such as water), they tend to agglomerate and disperse unevenly in the fluid, and the container wall and liquid surface after stirring Adhering and floating florfenicol with a large number of films, clusters and flocs
In this way, a large part of Florfenicol is digested (adhered, attached, etc.) by the drug delivery system during the administration process. It is difficult to dissolve from food, especially for poultry with a short digestive tract or livestock and poultry with digestive tract diseases. Many florfenicols are excreted before they are dissolved from food, and it is difficult to be absorbed by the digestive tract.

Method used

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  • Florfenicol soluble powder and preparation method thereof
  • Florfenicol soluble powder and preparation method thereof
  • Florfenicol soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Raw material composition:

[0037]

[0038] Preparation:

[0039] (1) Take 300g of Florfenicol and 500g of 95% ethanol, stir at a temperature of 50°C, and dissolve to obtain solution 1;

[0040] (2) Take 150g of sodium starch octenyl succinate, 250g of β-cyclodextrin, 200g of sodium citrate and 100g of sodium alginate, add them to 1000g of purified water, stir at a temperature of 50°C, and dissolve to obtain solution 2;

[0041] (3) After mixing solution 1 and solution 2, turn on the high-speed shear emulsifier, set the rotating speed at 3000rpm for emulsification; turn on the high-pressure homogenizer, set the homogenization pressure at 50MPa, and carry out high-pressure homogenization of the emulsified liquid to obtain Lotion;

[0042] (4) Turn on the spray dryer, set the temperature at 180° C., and rotate at 600 rpm, and spray-dry the emulsion obtained in step (3) to obtain the florfenicol soluble powder.

Embodiment 2

[0044] Raw material composition:

[0045]

[0046] Preparation:

[0047] (1) Take 200g of florfenicol and 450g of 95% ethanol, stir at a temperature of 35°C, and dissolve to obtain solution 1;

[0048] (2) Take 100g of sodium lauryl sulfate, 200g of β-cyclodextrin, 150g of sodium citrate and 50g of sodium alginate, add them to 1000g of purified water, stir at a temperature of 35°C, and dissolve to obtain solution 2;

[0049] (3) After mixing solution 1 and solution 2, turn on the high-speed shear emulsifier, set the rotation speed at 5000rpm for emulsification; turn on the high-pressure homogenizer, set the homogenization pressure to 30MPa, and carry out high-pressure homogenization of the emulsified liquid to obtain Lotion;

[0050] (4) Turn on the spray dryer, set the temperature at 160° C., and rotate at 600 rpm, and spray-dry the emulsion obtained in step (3) to obtain the florfenicol soluble powder.

Embodiment 3

[0052] Raw material composition:

[0053]

[0054]

[0055] Preparation:

[0056] (1) Take 250g of florfenicol and 400g of 95% ethanol, stir at a temperature of 65°C, and dissolve to obtain solution 1;

[0057](2) Take 120g of sodium dodecylbenzenesulfonate, 220g of β-cyclodextrin, 300g of sodium citrate and 80g of sodium alginate, add them to 1000g of purified water, stir at a temperature of 65°C, and dissolve to obtain solution 2;

[0058] (3) After mixing solution 1 and solution 2, turn on the high-speed shear emulsifier, set the rotating speed to 4000rpm for emulsification; turn on the high-pressure homogenizer, set the homogenization pressure to 70MPa, and carry out high-pressure homogenization of the emulsified liquid to obtain Lotion;

[0059] (4) Turn on the spray dryer, set the temperature at 200° C., and rotate at 600 rpm, and spray-dry the emulsion obtained in step (3) to obtain the florfenicol soluble powder.

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Abstract

The invention belongs to the field of veterinary drugs, and particularly relates to florfenicol soluble powder and a preparation method thereof. The florfenicol soluble powder is prepared from the following components in parts by weight: 200 to 300 parts of florfenicol, 100 to 150 parts of a surfactant, 200 to 250 parts of an inclusion agent, 150 to 300 parts of a cosolvent, 50 to 100 parts of a stabilizer, 400 to 500 parts of an organic solvent and 1000 parts of pure water. The florfenicol soluble powder provided by the invention is good in solubility, can be uniformly dispersed in fluid (such as water), is good in dissolution, good in quick release effect, very small in influence of water temperature, convenient to use and good in stability.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, in particular to a florfenicol soluble powder and a preparation method thereof. Background technique [0002] Florfenicol (florfenicol, FF), also known as fluthiamphenicol and fluprofen, is a white or off-white crystalline powder, odorless and bitter. Molecular formula is C 12 h 14 Cl 2 FNO 4 S, the chemical structural formula is as follows: [0003] [0004] Florfenicol is a new generation of chloramphenicol-type veterinary-specific broad-spectrum antibiotics developed by Schering-Plough in the late 1980s. It has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, high efficiency and safety, etc. The treatment effect of poultry bacterial diseases caused by it is remarkable, and it has effects on both Gram-positive bacteria and negative bacteria. [0005] Florfenicol is a time-dependent drug, and its bactericidal effect mainly depends on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/165A61K47/69A61K47/02A61K47/12A61P31/04
CPCA61K9/146A61K9/145A61K9/143A61K31/165A61P31/04Y02A50/30
Inventor 舒毅成陈玉龙徐根任永焕
Owner ZHEJIANG LANGBO PHARMA
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