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UCST type polymer with bacterium targeting function as well as preparation method and application of UCST type polymer

A polymer and targeting technology, applied in the field of UCST polymer and its preparation, can solve the problems of low loading or release efficiency of antibacterial drugs, mismatching phase transition temperature of UCST polymer, and poor antibacterial effect, etc., to achieve Stabilize drug coating effect, enhance in-situ bactericidal effect, and improve solubility

Active Publication Date: 2022-03-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the application process of UCST polymers and antibacterial drugs, there may be problems such as the phase transition temperature mismatch of UCST polymers, the loading efficiency or release efficiency of antibacterial drugs is not high, and the antibacterial effect is not good.

Method used

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  • UCST type polymer with bacterium targeting function as well as preparation method and application of UCST type polymer
  • UCST type polymer with bacterium targeting function as well as preparation method and application of UCST type polymer
  • UCST type polymer with bacterium targeting function as well as preparation method and application of UCST type polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] (1) Preparation of polymer P(AAm-co-AN-co-AcGlc)-1: AAm (300mg, 4.2mmol), AN (21.22mg, 0.4mmol), AcGlcEMA (184.17mg, 0.4mmol), CMDT ( 4.46mg, 0.014mmol), AIBN (0.46mg, 0.0028mmol) and 1.6mL DMSO were added to the reaction vessel and stirred until completely dissolved. The mixture was evacuated by a diaphragm pump for 10 min to remove oxygen, and placed in an oil bath at 70°C for 24 h. After the reaction, the reaction vessel was quenched by immersing in ice water. Then 20 mL of deionized water was added for dilution, and the mixture was dialyzed against deionized water for 3 days with a dialysis bag with a molecular weight cut-off of 3000 Da, and then freeze-dried to obtain polymer P(AAm-co-AN-co-AcGlc)-1.

[0075] (2) Preparation of polymer P(AAm-co-AN-co-Glc)-1: Weigh 1g of polymer P(AAm-co-AN-co-AcGlc)-1 and add 300mL of 2% NaOH solution , the reaction was stirred at 85°C for 8h. After the reaction, the pH value of the system was adjusted to 7.0-7.5 with 0.1 N HCl....

Embodiment 2

[0086] (1) Preparation of polymer P(AAm-co-AN-co-AcGlc)-2: AAm (307.14mg, 4.3mmol), AN (15.92mg, 0.3mmol), AcGlcEMA (184.17mg, 0.4mmol), CMDT (5.10mg, 0.016mmol), AIBN (0.79mg, 0.0048mmol) and 2mL DMSO were added to a 10mL polymerization tube and stirred until completely dissolved. The mixture was evacuated by a diaphragm pump for 10 min to remove oxygen, and placed in an oil bath at 70°C for 24 h. After the reaction, the polymerization tube was quenched by immersing in ice water. Then 20 mL of deionized water was added for dilution, and the mixture was dialyzed against deionized water for 3 days with a dialysis bag with a molecular weight cut-off of 3000 Da, and then freeze-dried to obtain polymer P(AAm-co-AN-co-AcGlc)-2.

[0087] (2) Preparation of polymer P(AAm-co-AN-co-Glc)-2: Weigh 1g of polymer P(AAm-co-AN-co-AcGlc)-2 and add 250mL of 5% NaOH solution , the reaction was stirred at 85°C for 7h. After the reaction, the pH value of the system was adjusted to 7.0-7.5 with...

Embodiment 3

[0090] (1) Preparation of polymer P(AAm-co-AN-co-AcGlc)-3: AAm (300mg, 4.2mmol), AN (18.57mg, 0.35mmol), AcGlcEMA (207.19mg, 0.45mmol), CMDT ( 4.14mg, 0.013mmol), AIBN (0.53mg, 0.00325mmol) and 1.5mL DMSO were added to a 10mL polymerization tube and stirred until completely dissolved. The mixture was evacuated by a diaphragm pump for 10 min to remove oxygen, and placed in an oil bath at 70°C for 24 h. After the reaction, the polymerization tube was quenched by immersing in ice water. Then 25 mL of deionized water was added for dilution, and the mixture was dialyzed against deionized water for 3 days with a dialysis bag with a molecular weight cut-off of 3000 Da, and then freeze-dried to obtain polymer P(AAm-co-AN-co-AcGlc)-3.

[0091] (2) Preparation of polymer P(AAm-co-AN-co-Glc)-3: Weigh 1g of polymer P(AAm-co-AN-co-AcGlc)-3 and add 200mL of 10% NaOH solution , the reaction was stirred at 85°C for 6h. After the reaction, the pH value of the system was adjusted to 7.0-7.5 ...

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses a UCST type polymer with a bacterium targeting function as well as a preparation method and application thereof. The method comprises the following steps: by taking an organic solvent as a reaction medium, carrying out polymerization reaction on acrylamide, acrylonitrile and a modified glucose monomer under the action of a chain transfer agent and an initiator, and removing acetyl to obtain the UCST polymer with the bacterial targeting function. The structure of the polymer is as shown in formula I. The polymer has the highest critical solution temperature and good biocompatibility. The polymer promotes the formation of bacterial aggregates and realizes a bacterial targeting function. The polymers of the present invention are useful as antibacterial carriers. The polymer has good antibacterial drug (photo-thermal reagent) coating capacity, and after the polymer is loaded with the photo-thermal reagent, the in-situ sterilization effect of the photo-thermal reagent is greatly enhanced through the targeting function of the polymer on bacteria under infrared light irradiation.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a UCST polymer with a bacteria targeting function, a preparation method and application thereof. Background technique [0002] A temperature-responsive polymer material is a "smart material" that is sensitive to changes in external temperature. When continuously heated or cooled, the temperature-sensitive polymer will undergo a phase transition between hydrophilic and hydrophobic. According to the phase transition temperature, thermosensitive polymers can be divided into two types of polymers with the lowest critical solution temperature (LCST) and the highest critical solution temperature (UCST). Based on the properties of these polymers, thermosensitive polymers have been widely used in the fields of drug delivery, bioseparation, and tissue engineering. In the field of drug delivery, LCST polymers are more widely used. However, compared with LCST-type...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/56C08F220/48C08F220/32C08F8/12A61K47/32
CPCC08F8/12C08F220/56A61K47/32C08F220/48C08F220/32Y02A50/30
Inventor 贾永光王琳黄雯刘卅陈凯峰林家炜
Owner SOUTH CHINA UNIV OF TECH
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