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Helicteres angustifolia polysaccharide with glycometabolism regulating activity as well as preparation method and application of helicteres angustifolia polysaccharide

A technology of mountain sesame and sugar metabolism, applied in the field of polysaccharides, to achieve high yield, high activity, and stable structure

Pending Publication Date: 2022-03-18
盐城康林达生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the improvement of sugar metabolism by Sesame polysaccharides

Method used

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  • Helicteres angustifolia polysaccharide with glycometabolism regulating activity as well as preparation method and application of helicteres angustifolia polysaccharide
  • Helicteres angustifolia polysaccharide with glycometabolism regulating activity as well as preparation method and application of helicteres angustifolia polysaccharide
  • Helicteres angustifolia polysaccharide with glycometabolism regulating activity as well as preparation method and application of helicteres angustifolia polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] This example provides a preparation method of Sesame polysaccharide with sugar metabolism regulating activity, the specific steps are as follows:

[0039] Step 1: add a certain volume of petroleum ether to the mountain sesame, with a solid-liquid ratio of 1:25 (g / mL), soak for 5 hours, filter and then soak in 90% ethanol for 5 hours, with a solid-liquid ratio of 1:25 ( g / mL), remove pigments, polyphenols and other impurities, soak for 5 h, filter, dry the filter residue naturally, and grind into coarse powder;

[0040] Step 2: Extract the polysaccharide from Sesame sesami with distilled water at 80-90 ℃, the ratio of solid to liquid is 1:30 (g / mL), soak for 2-3 h, ultrasonically assisted extraction, ultrasonic power 600W, microwave extraction time 20 min, extract The number of times is 3 times, the extracts are combined, centrifuged at 10000 rpm for 15 min, and the solutions are combined;

[0041] The third step: use the Sevag method to remove protein, the number of ti...

Embodiment 2

[0045] This example provides a preparation method of Sesame polysaccharide with sugar metabolism regulating activity, the specific steps are as follows:

[0046] Step 1: Add a certain volume of petroleum ether to sesame seeds, with a solid-liquid ratio of 1:30 (g / mL), and soak for 5 h. After filtering, soak in 90% ethanol for 5 h, the ratio of solid to liquid is 1:30 (g / mL), remove pigment, polyphenol and other impurities, dry naturally, and grind into coarse powder;

[0047] Step 2: Extract the polysaccharide from Sesame semen with distilled water at 80-90 ℃, the ratio of solid to liquid is 1:30 (g / mL), the ultrasonic power is 800W, the microwave extraction time is 30 min, and the extraction times are 4 times, the extracts are combined, concentrated, Centrifugal;

[0048] Step 3: Use the Sevag method to remove protein, the number of times is 7, and the obtained solution is rotary evaporated for 5-10 min;

[0049] Step 4: add absolute ethanol to the aqueous solution for alco...

Embodiment 3

[0052]This example provides a preparation method of Sesame polysaccharide with sugar metabolism regulating activity, the specific steps are as follows:

[0053] Step 1: Add a certain volume of petroleum ether to the sesame seeds, with a solid-liquid ratio of 1:40 (g / mL), and soak for 5 hours. After filtering, soak in 90% ethanol for 5 h, the ratio of solid to liquid is 1:40 (g / mL), remove pigment, polyphenol and other impurities, dry naturally, and grind into coarse powder;

[0054] The second step: Extract the polysaccharide from Sesame sesami with distilled water at 80-90 ℃, the ratio of solid to liquid is 1:40 (g / mL), the ultrasonic power is 1000W, the microwave extraction time is 40 min, the extraction times are 5 times, the extracts are combined, concentrated, Centrifugal;

[0055] Step 3: Use the Sevag method to remove protein, the number of times is 8 times, and the obtained solution is rotary evaporated for 5-10 min;

[0056] Step 4: Add absolute ethanol to the aqueo...

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Abstract

The invention discloses helicteres angustifolia polysaccharide with glycometabolism regulation activity and a preparation method and application thereof, and relates to application of helicteres angustifolia polysaccharide in the field of glycometabolism improvement, helicteres angustifolia is used as a raw material, soaked in petroleum ether for 5 h for degreasing, filtered, soaked in 80% ethanol for 5 h for decoloration, naturally aired and ground into coarse powder. Taking a certain amount of helicteres angustifolia powder, adding distilled water, soaking, carrying out ultrasonic-assisted extraction, combining extracting solutions, concentrating, centrifuging, removing protein from filtrate, carrying out alcohol precipitation, redissolving, dialyzing and freeze-drying to obtain helicteres angustifolia polysaccharide. Animal experiment results show that the helicteres angustifolia polysaccharide prepared in the invention has good glycometabolism regulation activity, can regulate the intestinal flora level, and has good development and application prospects.

Description

technical field [0001] The invention relates to the technical field of polysaccharides, in particular to a sesame polysaccharide with sugar metabolism regulating activity, a preparation method and application thereof. Background technique [0002] Diabetes is a common and frequently-occurring disease that seriously endangers human health. In recent years, the incidence has shown a significant upward trend. Diabetic patients need to take medicine for a long time and control their diet. At present, there is no good medicine to control diabetic complications. In order to better control the occurrence of diabetes, people should pay attention to the prevention of diabetes, and develop more health food with good function of improving glucose metabolism. [0003] Studies have shown that natural plants are an important treasure house for the development of hypoglycemic health foods. The polysaccharides contained in them have various activities such as immune regulation and impr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P3/10A61K36/185
CPCC08B37/0003A61K31/715A61P3/10A61K36/185
Inventor 程德林陈立根黄从军许伟邵荣
Owner 盐城康林达生物科技有限公司
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