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Preparation process of superfine azelaic acid

A preparation process and azelaic acid technology are applied in the field of preparation technology of ultrafine azelaic acid, which can solve the problems of poor solubility and stability of azelaic acid, difficult to popularize on a large scale, complicated process flow, etc. Prevents acne scarring and reduces allergies

Pending Publication Date: 2022-03-15
宏翼(广东)新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Azelaic acid needs to reach a concentration of 15% to have a good effect, but high-concentration azelaic acid has poor solubility and stability. CN201910922949.X discloses a preparation method of azelaic acid supramolecule, which comprises polyethylene glycol Mix alcohol and propylene glycol to obtain a mixed solvent; weigh azelaic acid and dissolve it in the mixed solvent to form an azelaic acid solution; put deionized water in a reaction vessel, heat to 95-100°C, and rotate at 400-700r / min Stir, and drop the azelaic acid solution into the above-mentioned deionized water at a rate of 0.5-1mL / min. The dropping temperature of the azelaic acid solution is controlled at 48-60°C. Continue stirring at a speed of min for 1.5-2.5 hours to obtain the supermolecule of azelaic acid
The present invention has high stability and good solubility, can effectively solve the problems of poor stability and solubility of azelaic acid, is conducive to preservation, can make full use of azelaic acid resources, and make it more useful in skin care and beauty; although the above patent Solved the problem of solubility and stability of azelaic acid, but the process is more complex, and there are problems of residual solvents, it is not easy to be popularized on a large scale, in order to solve this problem, we propose a preparation process of ultrafine azelaic acid

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  • Preparation process of superfine azelaic acid
  • Preparation process of superfine azelaic acid
  • Preparation process of superfine azelaic acid

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preparation example Construction

[0024] A kind of preparation technology of superfine azelaic acid, comprises the following steps:

[0025] S1. Pretreatment, place azelaic acid at a temperature below -18°C for 10-20 minutes, and the frozen powder is easier to crush;

[0026] S2. Negative pressure ultrasonic pulverization, send azelaic acid to the ultrasonic pulverizer for pulverization; at the same time, connect the negative pressure pump, pump out the air in the supersonic pulverizer, build a negative pressure environment, use ultrasonic waves to move inside the azelaic acid powder, To achieve the effect of breaking from the inside, supplemented by a negative pressure environment, it helps the powder of azelaic acid to break from the inside;

[0027] S3. Airflow crushing, after ultrasonic crushing, the frozen compressed air is fed in, and the compressed air is highly impacted in the pulverizer, driving the azelaic acid powder raw material to move at high speed, and the azelaic acid powder collides to make it...

Embodiment 1

[0030] A kind of preparation technology of superfine azelaic acid, comprises the following steps:

[0031] S1. Pretreatment, place azelaic acid at a temperature below -18°C for 10-20 minutes, and the frozen powder is easier to crush;

[0032] S2. Negative pressure ultrasonic pulverization, send azelaic acid to the ultrasonic pulverizer for pulverization; at the same time, connect the negative pressure pump, pump out the air in the supersonic pulverizer, build a negative pressure environment, use ultrasonic waves to move inside the azelaic acid powder, To achieve the effect of breaking from the inside, supplemented by a negative pressure environment, it helps the powder of azelaic acid to break from the inside;

[0033] S3. Airflow crushing, after ultrasonic crushing, the frozen compressed air is fed in, and the compressed air is highly impacted in the pulverizer, driving the azelaic acid powder raw material to move at high speed, and the azelaic acid powder collides to make it...

Embodiment 2

[0037] A kind of preparation technology of superfine azelaic acid, comprises the following steps:

[0038] S1. Pretreatment, place azelaic acid at a temperature below -18°C for 10-20 minutes, and the frozen powder is easier to crush;

[0039] S2. Negative pressure ultrasonic pulverization, send azelaic acid to the ultrasonic pulverizer for pulverization; at the same time, connect the negative pressure pump, pump out the air in the supersonic pulverizer, build a negative pressure environment, use ultrasonic waves to move inside the azelaic acid powder, To achieve the effect of breaking from the inside, supplemented by a negative pressure environment, it helps the powder of azelaic acid to break from the inside;

[0040] S3. Airflow crushing, after ultrasonic crushing, the frozen compressed air is fed in, and the compressed air is highly impacted in the pulverizer, driving the azelaic acid powder raw material to move at high speed, and the azelaic acid powder collides to make it...

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Abstract

The invention discloses a preparation process of superfine azelaic acid, which comprises the following steps: S1, pretreatment: placing azelaic acid at the temperature of-18 DEG C or below for 10-20 minutes; s2, negative-pressure ultrasonic crushing: conveying azelaic acid into an ultrasonic crusher for crushing; meanwhile, a negative pressure pump is communicated, air in the ultrasonic pulverizer is pumped out, and a negative pressure environment is constructed; s3, airflow crushing: after ultrasonic crushing, introducing frozen compressed air to carry out airflow crushing; and S4, centrifugal separation, wherein the crushed materials are fed into a centrifugal separator to be separated. The superfine azelaic acid prepared by the invention has better solubility than common azelaic acid, has better effect as a cosmetic raw material, has weak irritation to skin when being used, and can greatly reduce the allergy rate.

Description

technical field [0001] The invention relates to the technical field of azelaic acid preparation, in particular to a preparation process of ultrafine azelaic acid. Background technique [0002] Azelaic acid is a natural dicarboxylic acid produced by Malassezia furfur. It exists in whole grains, rye, barley and animal products, etc. It can also be formed by chemical synthesis, cracking and fermentation. Azelaic acid has antibacterial properties, can be used as a preservative for food and cosmetics, and can also be used in oral hygiene products to prevent dental caries; azelaic acid has significant penetration in the surface layer of the skin, and the penetration efficiency is several times that of dimethyl sulfoxide. In the emulsion system commonly used in cosmetics, azelaic acid is more efficient than dimethyl sulfoxide in carrying active ingredients into the cortex, and 43% to 64% of the drug can penetrate into the cortex, so it can be used as the penetration of emulsion and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/43C07C55/18
CPCC07C51/43C07C55/18
Inventor 唐永胡燕
Owner 宏翼(广东)新材料有限公司
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