Pharmaceutical composition for treating pulmonary tuberculosis and preparation method thereof

A composition and tuberculosis technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of liver function damage, prolongation of disease course, patient treatment interruption, etc., and achieve the effect of reducing the abnormal rate of liver function

Pending Publication Date: 2022-03-04
ZHUOHE PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, most of the current tuberculosis drugs can cause liver function damage, interrupt the treatment of patients, prolong the course of the disease, and affect the mood and treatment effect of patients

Method used

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  • Pharmaceutical composition for treating pulmonary tuberculosis and preparation method thereof
  • Pharmaceutical composition for treating pulmonary tuberculosis and preparation method thereof
  • Pharmaceutical composition for treating pulmonary tuberculosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] This embodiment discloses a tablet of a pharmaceutical composition for the treatment of pulmonary tuberculosis, which is composed of the following components:

[0023] Rifapentine 150g Glucuronolactone 400g pregelatinized starch 150g Hypromellose 50g Magnesium stearate 10g production 1000 pieces

[0024] Mix rifapentine and pregelatinized starch evenly, and then mix evenly with glucuronolactone. Then wet granulate with hydroxypropyl cellulose solution, dry at about 60°C, sieve, granulate, then add magnesium stearate for final mixing, measure the content of the intermediate granules and then press into tablets to obtain tablets.

Embodiment 2

[0026] The present embodiment discloses a capsule of a pharmaceutical composition for the treatment of tuberculosis, the capsule is composed of the following components:

[0027]

[0028]

[0029] Mix rifapentine with cornstarch and lactose evenly, and then mix evenly with glucuronolactone. After that, use povidone K30 solution as a binder for wet granulation, pass through a 24-mesh sieve for granulation, dry at about 60°C, sieve, granulate, and then add colloidal silica for final mixing. After the intermediate particle content is qualified , filling capsules to obtain capsules.

[0030] Below in conjunction with concrete case and clinical data, the beneficial effect of the present invention is further illustrated:

[0031] Selection of cases: Select 90 patients who were clearly diagnosed with pulmonary tuberculosis, including 49 males and 41 females. The oldest is 73 years old and the youngest is 24 years old.

[0032] Treatment method: According to different treatme...

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating pulmonary tuberculosis, which comprises a main drug and an auxiliary drug, and the main drug comprises rifapentine and glucurolactone. The main drugs comprise the following components in parts by weight: 0.5-5 parts of rifapentine and 0.5-10 parts of glucurolactone, and the weight ratio of the rifapentine to the glucurolactone is (0.375-0.75): 1. According to the pharmaceutical composition for treating pulmonary tuberculosis disclosed by the invention, the rifapentine and the glucurolactone are prepared into the pharmaceutical composition according to a reasonable proportion, so that the abnormal liver function rate of a patient is reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating pulmonary tuberculosis and a preparation method thereof. Background technique [0002] Pulmonary tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis infection, which can invade the lungs, intestines, kidneys, bones and joints and other organs of the whole body. The lung is the organ most easily invaded by Mycobacterium tuberculosis. Patients are an important source of infection. Humans are mainly infected by inhaling bacteria-carrying droplets (distributed when tuberculosis patients cough and sneeze). The tuberculosis bacteria that invade the respiratory tract are swallowed by alveolar macrophages. Only when the resistance is reduced or the cell-mediated allergic reaction is increased, clinical disease may be caused. If it can be diagnosed in time and given reasonable treatment, most of th...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/496A61K9/20A61K9/48A61P11/00A61P31/06
CPCA61K31/7048A61K31/496A61K9/2059A61K9/4866A61P11/00A61P31/06A61K2300/00
Inventor 薛丹露朱丽郁晨燕
Owner ZHUOHE PHARM GRP CO LTD
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