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Aziridine cross-linked N-halamine type antibacterial PVA sponge as well as preparation method and application thereof

An aziridine cross-linking agent and aziridine technology are applied in the directions of pharmaceutical formulations, pharmaceutical sciences, absorbent pads, etc., which can solve the problems of poor antibacterial durability, complex production process, poor safety of inorganic antibacterial agents, etc., and achieve long-lasting antibacterial properties. , Overcome the complex process, the effect of good antibacterial properties

Active Publication Date: 2022-03-01
INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006]Based on the existing antibacterial PVA sponge production process complex, poor antibacterial durability, poor safety of inorganic antibacterial agents, the invention discloses a kind of aziridine cross-linked N-halide Amine type antibacterial PVA sponge and preparation method thereof

Method used

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  • Aziridine cross-linked N-halamine type antibacterial PVA sponge as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: N halide type PVA molecular synthesis

[0044] Weigh 10g of PVA1799, add it to 100g of deionized water, heat in a water bath at 80°C, stir until the PVA is dissolved, add 0.5g of chloroacetaldehyde and 0.5g of glyoxylic acid, continue stirring for 3 hours, then add 1.13g of 1-chloro-2,2, 5,5-Tetramethyl-4-imidazolidinone continued to react for 3 hours to obtain N-halamine-type PVA aqueous solution, which was denoted as A1.

[0045] Weigh 10g of PVA2088, add it to 100g of deionized water, heat in a water bath at 80°C, stir until the PVA is dissolved, add 0.75g of chloroacetaldehyde and 0.5g of glyoxylic acid, continue stirring for 3 hours, then add 1.68g of 1-chloro-2,2 , 5,5-Tetramethyl-4-imidazolidinone continued to react for 3h to obtain an N-halamine-type PVA aqueous solution, denoted as A2.

[0046] Weigh 10g of PVA1799, add it to 100g of deionized water, heat in a water bath at 80°C, stir until the PVA is dissolved, add 1.0g of chloroacetaldehyde and...

Embodiment 2

[0049] Embodiment 2: preparation of aziridine cross-linked N-halamine type antibacterial PVA sponge

[0050] Add 0.3g emulsifier F68, 0.3g aziridine cross-linking agent trimethylolpropane-tris[3-(2-methyl aziridinyl) propionate] to the A1 solution prepared in the above example 1 , a small high-speed emulsifier with medium-high speed (speed 15000r / min) shear emulsification and cross-linking. After molding, place it in a -70°C refrigerator for 12 hours, and then put it in a freeze dryer for freeze-drying process to obtain N-halamine antibacterial PVA sponge, denoted as S1, the material has an antibacterial rate of 95% against Escherichia coli, 94% against Staphylococcus aureus, and a liquid absorption rate of 19.7g / g.

[0051] It should be noted that in the technology of the present invention, the antibacterial group N-halamine is bound to the PVA molecule through a chemical covalent bond, so that the prepared PVA sponge has durable antibacterial properties.

Embodiment 3

[0052] Embodiment 3: preparation of aziridine cross-linked N-halamine type antibacterial PVA sponge

[0053] Add 0.2g emulsifier F68, 0.3g aziridine cross-linking agent trimethylolpropane-three [3-(2-methyl aziridinyl) propionate] to the A2 solution prepared in the above-mentioned embodiment 1 , a small high-speed emulsifier with medium-high speed (speed 15000r / min) shear emulsification and cross-linking. After molding, place it in a -70°C refrigerator for 12 hours, and then put it in a freeze dryer for freeze-drying process to obtain N-halamine antibacterial PVA sponge, denoted as S2, the material has an antibacterial rate of 97% against Escherichia coli, 96% against Staphylococcus aureus, and a liquid absorption rate of 17.5g / g.

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Abstract

The invention discloses a preparation method of aziridine cross-linked N halamine type antibacterial PVA (polyvinyl alcohol) sponge, and belongs to the field of biomedical materials. The preparation method comprises the following steps: firstly, reacting PVA with chloroacetaldehyde and glyoxylic acid to obtain PVA containing carbon-chlorine bonds and carboxyl groups, then reacting with 1-chloro-2, 2, 5, 5-tetramethyl-4-imidazolinone to obtain PVA molecules with halamine groups, further adopting an aziridine cross-linking agent for cross-linking, emulsifying and forming, and freeze-drying to obtain the N halamine type antibacterial PVA sponge. The prepared N halamine type PVA sponge has good antibacterial performance and liquid absorption performance, and can be used as a hemostatic material and a wound dressing; the preparation process is simple, and the prepared sponge material is lasting in antibacterial property, safe and non-toxic, overcomes the defects that an existing antibacterial PVA sponge is complex in preparation process, poor in antibacterial durability and poor in inorganic antibacterial agent safety, and is suitable for market popularization and application.

Description

technical field [0001] The invention belongs to the technical field of medical material preparation, and relates to the preparation and application of a biomedical material. More specifically, it relates to an aziridine-crosslinked N-halamine type antibacterial PVA sponge and its preparation method and application. Background technique [0002] Medical wound dressing is an important biomedical material used to cover sores, wounds or other injuries. It can cover skin wounds to protect the wound, avoid secondary damage to the skin, and provide a favorable environment for wound healing. Its research and development has always been a hot issue. An ideal dressing should be able to prevent bacterial invasion, cover and protect the wound from infection. A good antibacterial dressing must have the ability to penetrate the eschar, broad-spectrum antibacterial, not easy to produce drug resistance, no local irritation, and no systemic adverse reactions. At present, antibiotic drug d...

Claims

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Application Information

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IPC IPC(8): C08J9/28C08J3/24C08L29/04C08K5/3412C08F8/28C08F8/30C08F116/06A61L15/20A61L15/24A61L15/42A61L15/46
CPCC08J9/28C08J3/24C08F8/28C08F8/30A61L15/425A61L15/46A61L15/42A61L15/24A61L15/20A61L2400/04A61L2300/204A61L2300/602A61L2300/404C08J2201/0484C08J2329/04C08K5/3412C08F116/06C08L29/04
Inventor 孙复钱张军董晓娜曾国屏
Owner INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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