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Acetyl tetrapeptide-5 analogue with anti-wrinkle effect and moisturizing peptide containing it

An acetyl tetrapeptide and analog technology, applied in the field of moisturizing peptides and acetyl tetrapeptide-5 analogs, can solve problems such as inability to meet cosmetic needs, lack of skin permeability, and stability, and achieve increased moisturizing and moisturizing effects. Good skin absorption and improved stability

Active Publication Date: 2022-04-12
浙江湃肽生物股份有限公司深圳分公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the research and development of acetyl tetrapeptide-5 cosmetics, the demand for acetyl tetrapeptide-5 is increasing year by year, and the current cosmetics containing acetyl tetrapeptide-5 still have certain defects, such as skin permeability, stability, etc. There are still deficiencies, so acetyl tetrapeptide-5 can no longer meet the needs of current cosmetics

Method used

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  • Acetyl tetrapeptide-5 analogue with anti-wrinkle effect and moisturizing peptide containing it
  • Acetyl tetrapeptide-5 analogue with anti-wrinkle effect and moisturizing peptide containing it
  • Acetyl tetrapeptide-5 analogue with anti-wrinkle effect and moisturizing peptide containing it

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1: Moisturizing peptide with anti-wrinkle effect

[0056] Moisturizing peptide with anti-wrinkle effect, by weight percentage, includes the following components: 6% acetyl tetrapeptide-5 analogue, 2.8% benzyl carbamate modified sodium alginate, 1% isooctyl ferulic acid, 14% glycerin, 18% ethanol, 1% glyceryl stearate, 1% citric acid, the balance of deionized water.

[0057] The acetyl tetrapeptide-5 analog is prepared by the following method:

[0058] Step 1. Mix 15.5 g of histidine with 60 g of methanol, add 0.3 g of thionyl chloride and 0.1 g of dimethylformamide at 0°C, stir for 20 min, then raise the temperature to 75°C and stir for 6 h. Methanol was distilled off under reduced pressure, and crystallized with ethanol to obtain 16.9 g of compound 1;

[0059] Step 2. Dissolve 2.5 g of tyrosine in 400 g of acetone / tetrahydrofuran mixed solution with a mass ratio of 2:1, add 0.3 g of 1-hydroxybenzotriazole, 0.2 g of dicyclohexylcarbodiethylene at 0°C Amine, s...

Embodiment 2

[0069] Example 2: Moisturizing peptide with anti-wrinkle effect

[0070] Moisturizing peptide with anti-wrinkle effect, by weight percentage, including the following components: 6% acetyl tetrapeptide-5, 2.8% benzyl carbamate modified sodium alginate, 1% isooctyl ferulic acid, 14% Glycerin, 18% ethanol, 1% citric acid, the balance of deionized water.

[0071] The benzyl carbamate-modified sodium alginate is the same as in Example 1, and the preparation method of the moisturizing peptide is the same as in Example 1.

Embodiment 3

[0072] Example 3: Moisturizing peptide with anti-wrinkle effect

[0073] Moisturizing peptide with anti-wrinkle effect, by weight percentage, including the following components: 6% acetyl tetrapeptide-5 analogue, 2.8% sodium alginate, 1% isooctyl ferulic acid, 14% glycerin, 18% Ethanol, 1% citric acid, the balance of deionized water.

[0074] The acetyl tetrapeptide-5 analog is the same as in Example 1, and the preparation method of the moisturizing peptide is the same as in Example 1.

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Abstract

The invention provides an acetyl tetrapeptide-5 analog with anti-wrinkle effect and a moisturizing peptide containing the same, belonging to the field of polypeptide cosmetics. The moisturizing peptide is added with 1.2-4% benzyl carbamate modified alginic acid and 0.8-1.5% isooctyl ferulic acid by weight. Through the synergistic effect of each component, it has high stability and can be absorbed by the skin. It has the functions of moisturizing, anti-wrinkle and removing eye bags. It can remove wrinkles and eye bags around the eyes, prevent the occurrence of wrinkles and eye bags around the eyes, promote skin metabolism, stimulate the production of new skin cells, and make the skin delicate and shiny with little side effects. , high safety, long-term use.

Description

technical field [0001] The invention belongs to the field of polypeptide cosmetics, and in particular relates to an acetyl tetrapeptide-5 analog with anti-wrinkle effect and a moisturizing peptide containing the same. Background technique [0002] Aging is an inevitable process for human beings, and the eyes are the part of the face that is most likely to age and reveals its age the earliest. As we age, our skin will gradually lose its elasticity, cells will age, water will be lost, and wrinkles and bags under the eyes will form around the eyes. With the improvement of people's living standards, various anti-wrinkle and eye bag-removing cosmetics have been developed one after another. [0003] Acetyl tetrapeptide-5, also known as eye serine peptide, is one of the earliest and most widely used beauty peptides. Acetyl tetrapeptide-5 can improve the microcirculation of eye skin by inhibiting angiotensin-converting enzyme, increase the activity of SOD, inhibit its glycosylatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K5/02C07K1/02A61K8/64A61K8/37A61K8/73A61Q19/08A61Q19/00
CPCC07K5/0205A61K8/64A61K8/37A61K8/733A61Q19/08A61Q19/005A61Q19/00A61K2800/592
Inventor 黄毅钱令页傅小明应佳伟
Owner 浙江湃肽生物股份有限公司深圳分公司
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