Compound liquorice tablet capable of being prepared by dry powder direct compression process and preparation method of compound liquorice tablet

Abstract

The invention discloses a compound liquorice tablet capable of being prepared by a dry powder direct compression process and a preparation method of the compound liquorice tablet. The preparation method comprises the following steps: weighing, primarily mixing, sieving, dissolving and adsorbing, premixing, totally mixing, tabletting and packaging. By controlling the average particle size of the primary mixture (the mixture of the licorice extract, the poppy fruit extract powder and the sodium benzoate), the appearance of the preparation is fundamentally ensured; by screening and selecting a novel auxiliary material polyvinylpyrrolidone, the problems of compressibility and dissolution rate are solved; by using silicon dioxide, the problems of adsorption and stability of volatile oil are solved, and the flowability and compressibility of particles are improved; by using a direct tabletting method, the process is simplified, the efficiency is improved, the content of volatile oil in a finished product is increased, the curative effect is improved, and the quality of the compound liquorice tablet is integrally improved.

Description

technical field [0001] The invention relates to the technical field of medicine manufacturing, in particular to a compound licorice tablet which can be used in a dry powder direct compression process and a preparation method thereof. Background technique [0002] Compound licorice tablet is a unique natural compound preparation in my country. It contains licorice extract, poppy fruit extract powder, camphor, star anise oil and other traditional Chinese medicine ingredients. With definite curative effect, high quality and low price, it has been used in my country for more than 60 years and is welcomed by both doctors and patients. [0003] The traditional preparation process of Compound Licorice Tablets is that after wet granulation of licorice extract and other raw and auxiliary materials, fine particle powder or necessary additional auxiliary materials are used to absorb volatile oil, and then mixed with other granules and pressed into tablets. Among them, fine particle pow...

AI Technical Summary

Problems solved by technology

Among them, fine particle powder or external auxiliary materials cannot completely absorb volatile oil or the effect is poor, and the fluidity of the obtained particles is poor, which often leads to the following defects in tablet compression:

[0004] (1) It has poor fluidity and cannot be pressed smoothly;

[0005] (2) Tablets can be pressed smoothly, but the compressibility is low, and it is easy to have unqualified friability, and even the situation of missing edges and corners during transportation;

[0006] (3) The tablet hardness is high but the friability is still unqualified;

[0007] (4) Appearance problems such as white spots and pockmarks are prone to appear on the surface of the tablet, which affects the use of consumers;

[0008] (5) The volatile oil content of the finished product is low, which affects the therapeutic effect;

[0009] (6) The content of main components in tablet batches varies greatly, which may affect the curative effect

[0010] In addition, the patent CN104382993A discloses a compound licorice tablet and its preparation process. The powder is directly pressed into tablets, and the volatile oil is adsorbed by one or more combinations of calcium hydrogen phosphate, calcium carbonate, aluminum oxide and magnesium oxide. The adsorption effect is relatively high. Poor, resulting in lower tablet volatile oil content and lower compressibility (see Comparative Example 11 of the present invention)

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