Flow type synthesis device and synthesis method of nanogel

Abstract

The invention belongs to the technical field of biomedical material synthesis, and particularly relates to a flow type synthesis device of nanogel. The device comprises an injection pump sample introduction system, a pipeline synthesis system, a product post-treatment system and a product collection system which are connected in sequence, the injection pump sample introduction system comprises a liquid sample introduction system, a gas sample introduction system and a liquid mixing pipeline, the liquid sample introduction system is connected with one end of a pipeline synthesis system through the liquid mixing pipeline, and the gas sample introduction system is directly connected with the pipeline synthesis system. The invention further provides a method for synthesizing the nanogel by using the flow type synthesis device. The invention has the beneficial effects that the specific surface area of heat exchange between reactants and the outside can be increased, the influence of temperature on the reactants and polymerization reaction is reduced, and uniform mixing of liquid is facilitated; the synthesis method is simple to operate and mild in synthesis condition, and has a wide application prospect in the biomedical field.

Description

technical field [0001] The invention belongs to the technical field of synthesis of biomedical materials, and in particular relates to a nanogel flow synthesis device and a synthesis method thereof. Background technique [0002] Protein therapy has attracted widespread attention due to its high specificity and low toxicity. However, direct delivery of proteins has problems such as low delivery efficiency and immune response. Drug carriers are an effective way to solve these problems. However, most of the current drug carriers use batch synthesis devices, which have problems such as complicated preparation process and high price, which limit their clinical application and development. Therefore, the development of a drug carrier with simple preparation, good biocompatibility and low cost is still an urgent problem to be solved. [0003] Polyethylene glycol (PEG) is a hydrophilic polymer commonly used in nano-drug carriers at present, and has the advantages of good hydrophil...

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Problems solved by technology

[0007] In order to overcome the problems of complex preparation process and limited synthesis device in the prior art, the present invention provides a nanogel flow type synthesis device and its synthesis method, which can increase the specific surface area of ​​heat exchange between reactants and the outside world, Reducing the influence of temperature on reactants and polymerization reactions is beneficial to the uniform mixing of liquids; the synthesis method is simple to operate and the synthesis conditions are mild, and has broad application prospects in the biomedical field

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