Application of three-kernel decoction to preparation of medicine for treating fatty liver disease

Abstract

The invention relates to an application of a three-kernel decoction to preparation of a medicine for treating fatty liver diseases. The three-kernel decoction consists of the following raw material medicines in parts by weight: 6-24 parts of apricot kernels, 9-36 parts of talc, 3-12 parts of ricepaperplant pith, 3-12 parts of amomum cardamomum, 3-12 parts of bamboo leaves, 3-12 parts of mangnolia officinalis, 9-36 parts of raw coix seeds and 5-20 parts of pinellia ternate. The three-kernel decoction has the effects of smoothing qi activity and eliminating dampness and heat, is applied to treatment of mice with non-alcoholic fatty liver diseases induced by a high fat diet, and can remarkably reduce fatty degeneration, ballooning degeneration and inflammatory cell infiltration of liver cells of the mice and reduce the content of TG in the liver; and the ALT activity of mouse serum can be reduced, the liver function of the mice is improved, and the insulin resistance of the mice is improved. According to the invention, a new medical application is explored for a known traditional Chinese medicine composition, namely the three-kernel decoction, and a new application field is developed.

Description

technical field [0001] The invention relates to the technical field of medical applications, in particular to the application of Sanren decoction in the preparation of medicines for treating fatty liver disease. Background technique [0002] Fatty liver refers to the lesion of excessive fat accumulation in liver cells caused by various reasons. It is a common pathological change of the liver, rather than an independent disease. Fatty liver disease is seriously threatening the health of the Chinese people, becoming the second largest liver disease after viral hepatitis, the incidence rate is constantly increasing, and the age of onset is getting younger. Normal human liver tissue contains a small amount of fat, such as triglyceride (Triglyceride, TG), phospholipids, glycolipids and cholesterol, etc., and its weight is about 3%-5% of the liver weight. If there is too much fat accumulation in the liver, when When the lipid content in the liver exceeds 5% of the wet weight of t...

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Problems solved by technology

But there is no report about the application of Sanren Decoction of the present invention in the preparation of medicines for the treatment of fatty liver disease

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