Anti-hepatitis natural medicine compound preparation, preparation method and application thereof

Abstract

The invention discloses an anti-hepatitis natural medicine compound preparation, a preparation method and application thereof, wherein the compound preparation is prepared from liquorice and spirulina with the mass ratio of 1-6:1-6, and the preparation method comprises the following steps of: preparing liquorice fermentation liquor through smash, high-pressure steam crush, enzymolysis, ultra-finepulverization, water exaction and fermentation treatment of the liquorice; preparing spirulina fermentation liquor through smash, ultra-fine pulverization and fermentation treatment of the spiruline;and mixing the liquorice fermentation liquor with the spirulina fermentation liquor, centrifuging to remove bacteria, removing the residual bacteria in supernatant through ultrasound, merging the supernatant and medicine gunk, destroying enzyme through high temperature, and then drying to obtain the compound preparation. The invention has the advantages of novel formula, unique preparation process, high content of anti-hepatitis effective constituents, good oral bioavailability and significant effect in the aspects of virus hepatitis relapse inhibition, inflammation recovery facilitation and liver function stabilization, and can be used as an intermediate for preparing anti-hepatitis drugs.

Description

technical field [0001] The invention relates to a compound preparation, in particular to a compound preparation of anti-hepatitis natural medicine, and also relates to a preparation method and application of the compound preparation. Background technique [0002] my country is a big hepatitis country, with about 130 million hepatitis B virus carriers, nearly 30 million chronic hepatitis B patients and a similar number of other types of hepatitis patients. Providing better treatment drugs and methods for these patients is of great significance to protecting people's health and maintaining social stability. At present, the mainstream treatment options for chronic viral hepatitis include etiological treatment and liver-protecting treatment. Among them, liver-protecting drugs account for more than 1 / 3 of the consumption of liver disease drugs in my country, but there are very few first-line drugs that are recognized as effective and stable. There is an urgent need for new antivi...

AI Technical Summary

Problems solved by technology

At present, commercially available spirulina preparations are mainly spirulina powder or tablets or capsules made of spirulina powder according to conventional preparation methods. The preparation method has the following problems: ①The protein contained in spirulina mainly exists in the spirulina cells However, the cell wall of Spirulina is thicker, the inner wall contains peptidoglycan, and the outer wall contains lipoprotein, lipopolysaccharide and colloidal sheath. Simple crushing method can not destroy the cell wall of Spirulina, and it is difficult to release intracellular protein; ②The protein contained in Spirulina Most of them are high proteins with a molecular weight of more than 50,000, which can only be absorbed and utilized by the human body after being digested into oligopeptides, and the human body's own digestibility is very low; ③Some biologically active peptides exist in proteins in an inactive state In the polypeptide chain, only when it is released by the action of protease can it exert biological activity

[0005] So far, there have been no relevant research reports on compound preparations of licorice and spirulina at home and abroad

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