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Modified sodium alginate, preparation method thereof, pressure-sensitive adhesive and patch

A technology of sodium alginate and pressure-sensitive adhesive, which is applied in its preparation, modified sodium alginate, pressure-sensitive adhesive and patches, can solve the problems of good skin affinity and moderate peel strength, and achieve good skin affinity, Good bonding stability, the effect of reducing the risk of skin allergies

Pending Publication Date: 2022-01-07
ANHUI HUIKE BIO ENG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to provide a modified sodium alginate, its preparation method, pressure-sensitive adhesive and patch, so as to solve the problem that the existing patch cannot satisfy both good skin affinity and moderate peel strength

Method used

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  • Modified sodium alginate, preparation method thereof, pressure-sensitive adhesive and patch

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preparation example Construction

[0018] As described in the background art, the existing patch has the problem that it cannot satisfy both good skin affinity and moderate peel strength. In order to solve the above-mentioned technical problems, the application provides a preparation method of modified sodium alginate. The preparation method of modified sodium alginate comprises: mixing sodium alginate with lye to obtain sodium alginate solution; making sodium alginate The solution is grafted with N-(2-chloroethyl)phthalimide to obtain modified sodium alginate.

[0019] Sodium alginate is a by-product of extracting iodine and mannitol from brown algae kelp or sargassum. It is a natural polysaccharide with the stability, solubility, viscosity and safety required for pharmaceutical excipients. Sodium alginate is soluble in water but insoluble in organic solvents such as ethanol, ether, and chloroform. The aqueous solution of sodium alginate has a high viscosity and has been used as a thickener, stabilizer, and em...

Embodiment 1

[0036] A breathable medical temperature-controlled hot compress, including a non-woven bag, a heating layer arranged inside the non-woven bag, and a pressure-sensitive tape for fixing the non-woven bag. The pressure-sensitive tape is made of a pressure-sensitive adhesive with a thickness of 35 μm and Composition of release paper.

[0037] The preparation method of pressure-sensitive adhesive is as follows:

[0038] (1) 47g of sodium alginate was heated and dissolved in an aqueous solution of sodium hydroxide having a mass concentration of 5% at 60° C. to obtain a sodium alginate solution.

[0039] (2) 48 g of N-(2-chloroethyl)phthalimide was dissolved in tetrahydrofuran to obtain N-(2-chloroethyl)phthalimide solution.

[0040] (3) Add N-(2-chloroethyl)phthalimide solution dropwise to the sodium alginate solution, heat to 70°C, keep stirring and react for 8 hours, let it stand for stratification, take the water phase, concentrate and remove water , to obtain modified alginic ...

Embodiment 2

[0043] A breathable medical temperature-controlled hot compress, including a non-woven bag, a heating layer arranged inside the non-woven bag, and a pressure-sensitive tape for fixing the non-woven bag. The pressure-sensitive tape is made of a pressure-sensitive adhesive with a thickness of 35 μm and Composition of release paper.

[0044] The preparation method of pressure-sensitive adhesive is as follows:

[0045] (1) 47g of sodium alginate was heated and dissolved in an aqueous solution of sodium hydroxide having a mass concentration of 5% at 60° C. to obtain a sodium alginate solution.

[0046] (2) 52 g of N-(2-chloroethyl)phthalimide was dissolved in tetrahydrofuran to obtain N-(2-chloroethyl)phthalimide solution.

[0047] (3) Add N-(2-chloroethyl)phthalimide solution dropwise to the sodium alginate solution, heat to 70°C, keep stirring and react for 8 hours, let it stand for stratification, take the water phase, concentrate and remove water , to obtain modified alginic ...

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Abstract

The invention provides modified sodium alginate, a preparation method thereof, a pressure-sensitive adhesive and a patch. The preparation method of the modified sodium alginate comprises the following steps: mixing sodium alginate with alkali liquor to obtain a sodium alginate solution; and carrying out a grafting reaction on the sodium alginate solution and N-(2-chloroethyl)phthalimide to obtain the modified sodium alginate. The pressure-sensitive adhesive prepared from the modified sodium alginate can obtain relatively good bonding stability and relatively proper peel strength. Meanwhile, due to the fact that the modified sodium alginate has good skin-friendly performance, the risk of skin allergy can be well reduced in the application process of the modified sodium alginate.

Description

technical field [0001] The invention relates to the field of medical patches, in particular to a modified sodium alginate, a preparation method thereof, a pressure-sensitive adhesive and a patch. Background technique [0002] The hot compress is a moxibustion paste for external use, which is suitable for pregnant women to warm the uterus. It has the following effects: nourishing the essence, promoting blood circulation and removing stasis, warming the meridian and relieving pain, expelling wetness and cold; reconciling qi and blood, improving microcirculation, warming the palace and protecting yin, warming the meridian and activating blood circulation, maintaining the ovaries, promoting uterine contraction, and comprehensively conditioning Female reproductive system. [0003] The hot compress usually consists of a non-woven fabric bag, a heating material arranged inside the non-woven fabric bag, and a pressure-sensitive adhesive tape for fixing the non-woven fabric bag. Pr...

Claims

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Application Information

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IPC IPC(8): C08B37/04C09J7/38C09J105/04C09J11/04C09J11/06A61K9/00A61K9/70A61K47/02A61K47/18A61K47/36
CPCC08B37/0084C09J7/38C09J105/04C09J11/04C09J11/06A61K9/7046A61K9/0004A61K47/36A61K47/02A61K47/183C09J2301/302C09J2301/408C09J2301/122C08K3/34C08K5/42
Inventor 黄海东黄振伟付钦中
Owner ANHUI HUIKE BIO ENG TECH
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