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Reduced nicotinamideribosides for treating or preventing kidney disease

A nicotinamide riboside and reduced technology, which is applied in the field of reduced nicotinamide riboside for the treatment or prevention of kidney diseases, can solve the problems of unreliable improvement of survival rate and reduce renal cell apoptosis , reduce glomerular expansion, and prevent blood urea nitrogen from increasing

Pending Publication Date: 2022-01-04
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other than dialysis and kidney transplantation, there are no known interventions that reliably improve survival, limit damage, or enhance recovery from CKD
[0006] Accordingly, there is an urgent, unmet need to address renal disease, particularly AKI, with new compounds, compositions and methods for the prevention and / or treatment of AKI and CKD

Method used

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  • Reduced nicotinamideribosides for treating or preventing kidney disease
  • Reduced nicotinamideribosides for treating or preventing kidney disease
  • Reduced nicotinamideribosides for treating or preventing kidney disease

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Embodiment approach

[0040] The present invention provides compounds and compositions consisting of reduced nicotinamide riboside. Another aspect of the invention is a unit dosage form of a composition consisting of reduced nicotinamide riboside and comprising an amount effective to increase intracellular NAD in a subject in need thereof + reduced nicotinamide riboside.

[0041] In the prevention or treatment of kidney disease, NAD + An increase in biosynthesis can be provided by an individual such as a human (e.g., a human undergoing medical treatment), a pet or a horse (e.g., a pet or horse undergoing medical treatment), or a cow or poultry (e.g., a cow or poultry used in agriculture). One or more beneficial effects.

[0042] For non-human mammals such as rodents, some embodiments include administering an amount of the composition that provides from 1.0 mg to 1.0 g reduced nicotinamide riboside per kg body weight of the non-human mammal, preferably from 10 mg to 500 mg Reduced nicotinamide ri...

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Abstract

The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and / or treatment of kidney diseases and conditions. In one embodiment of the invention, the compounds and compositions of the invention improve kidney function by reducing formation of kidney cysts, reducing glomerule dilatation, reducing renal cell apoptosis and preventing increases in blood urea nitrogen. In another embodiment of the invention, the compounds and compositions of the invention may be used in the methods to prevent and / or treat acute kidney injury (AKI), chronic kidney disease, diabetic nephropathy, focal segmental glomerulosclerosis, nephrotic syndrome, renal fibrosis and kidney cancer.

Description

technical field [0001] The present invention provides compounds and compositions comprising reduced nicotinamide riboside for use in methods of preventing and / or treating renal diseases and disorders. In one embodiment of the present invention, the compounds and compositions of the present invention improve renal function by reducing renal cyst formation, reducing glomerular dilation, reducing renal cell apoptosis, and preventing increases in blood urea nitrogen. In another embodiment of the present invention, the compounds and compositions of the present invention are useful for preventing and / or treating acute kidney injury (AKI), chronic kidney disease, diabetic nephropathy, focal segmental glomerulosclerosis , nephrotic syndrome, renal fibrosis, and renal cancer. Background technique [0002] Acute kidney injury (AKI), also known as acute kidney failure, is generally more reversible than chronic kidney failure (CKD). However, AKI still carries high mortality and is a k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P13/12A61P35/00A61P43/00A61K9/00A23L2/00
CPCA61K31/706A61P13/12A61P35/00A61P43/00A61K9/0019A61K9/0053
Inventor C·坎托阿尔瓦雷斯S·克里斯廷M·P·吉纳J·吉鲁德-格贝坦特S·莫科S·巴托娃M·米高
Owner SOC DES PROD NESTLE SA
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