Copolyester and preparation method thereof

A cross-linked polyester and esterification technology, which is applied in medical science, surgery, surgical adhesives, etc., can solve problems such as allergic reactions and non-degradable, and achieve good biocompatibility, high viscosity, and good hydrophilicity Effect

Pending Publication Date: 2021-12-31
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the patent improves the strength and healing properties of the adhesive, this adhesive is a cyanoacrylate medical adhesive, which may cause some allergic reactions due to the presence of cyano and other groups
[0006] The bionic mussel adhesive described in the literature (Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications[J].Angewandte Chemie.) has the characteristics of good biocompatibility and good viscosity, but due to the limitation of molecular structure, it is not degradable

Method used

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  • Copolyester and preparation method thereof
  • Copolyester and preparation method thereof
  • Copolyester and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Weigh 0.09mol citramalic acid, 0.01mol succinic acid, 0.25mol ethylene glycol, 5mmol tetrabutyl titanate and 0.01mol glycerin, add these materials into a 100ml three-necked flask, and fill the reaction system with nitrogen protection Gas, turn on the stirring (rotational speed is 80r / min), turn on the oil bath and heat to 160°C for esterification for 1h, 180°C for 5h, then turn on the vacuum pump to evacuate the reaction system to 100Pa, heat up to 200°C, and wait for the reaction system to reach 200 ℃, start timing, polycondensation 2h. After the reaction, the vacuum pump was stopped, and the polyester was taken out, which was recorded as the polymer 10% Gly-PECS. The samples were characterized by tests such as molecular weight, glass transition temperature Tg, and elongation at break.

Embodiment 2

[0056] Weigh 0.25 mol of 1,4-butanediol to replace ethylene glycol, the amount of other substances and the polyester synthesis method are the same as in Example 1, and the prepared polymers are respectively recorded as polymer 10% Gly-PBCS.

Embodiment 3

[0058] Weigh 0.005 mol of citric acid instead of glycerin, the amount of other substances and polyester synthesis method are the same as in Example 1, and the prepared polymers are respectively recorded as polymer 5% Cit-PBCS.

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Abstract

The invention relates to citramalic acid-based cross-linked polyester as well as a preparation method and application thereof. Specifically, citramalic acid, succinic acid, a saturated straight-chain end group dihydroxy compound and a polyfunctional alcohol compound and / or a polyfunctional acid compound are used as raw materials; and the copolyester with excellent adhesive property is obtained through esterification reaction and polycondensation reaction for polycondensation and cross-linking, and the preparation method and the application of the copolyester are also provided. Compared with other medical adhesive polyesters, the synthesized polyester has excellent properties such as high strength, high viscosity, good skin adhesion and degradability, has the remarkable advantages of good practicability, good application prospects and the like, and can be applied to wearable monitoring equipment, medical wound adhesives and the like.

Description

technical field [0001] The invention relates to a citramalic acid-based cross-linked polyester and a preparation method thereof, belonging to the technical field of material synthesis. Background technique [0002] Biomaterials play an increasingly important role in biomedical engineering, especially tissue engineering, controlled drug release, implants, and medical devices. Especially for biodegradable materials, the degradation performance ensures that the materials will not remain in the body after performing their due functions. Biodegradable elastomers, based on their excellent mechanical properties, can be used to support the repair and regeneration of soft tissues. [0003] At the same time, materials for smart wearable devices have also attracted extensive attention. They can detect subtle changes in external force and deformation, and convert these changes into recordable electrical signals, so they play an important role in health monitoring, artificial intelligen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/60A61L24/04
CPCC08G63/60A61L24/046C08L67/00
Inventor 郑明远宋蕾周光远周茉王瑞张涛
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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