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Application of nano material in preparation of medicine for treating atherosclerosis

An atherosclerosis and nanomaterial technology, applied in the field of biomedical applications of nanomaterials, can solve problems such as changing the composition of plaques, accelerating the development of atherosclerosis, affecting the stability of plaques, and improving the therapeutic effect.

Pending Publication Date: 2021-12-24
CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although moderate apoptosis can inhibit the progression of atherosclerosis, it is difficult to achieve moderate apoptosis control in specific treatments, and the accumulation of apoptosis itself is an independent risk factor for atherosclerosis, which will change plaque Plaque composition, affect plaque stability, accelerate atherosclerosis development

Method used

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  • Application of nano material in preparation of medicine for treating atherosclerosis
  • Application of nano material in preparation of medicine for treating atherosclerosis
  • Application of nano material in preparation of medicine for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Embodiment 1 core material black TiO 2 Preparation of nanoparticles

[0088] Sodium borohydride (NaBH 4 ) reduction method to prepare black TiO 2 nanoparticles. Weigh commercial P25 TiO 2 Nanoparticles 20.0 g, NaBH 4 5.0 g of powder, the two were mixed and ground for 60 minutes at room temperature with a mortar. The ground mixture was transferred to a ceramic boat, placed in a tube furnace, and heated at a rate of 10°C per minute from room temperature to 350°C in a high-purity Ar atmosphere for 180 minutes. Black TiO can be obtained after natural cooling of the reactants 2 Nanoparticles, dispersed in absolute ethanol, centrifuged at 11,000 rpm for 10 min, repeated 3 times, then dispersed in ultrapure water, centrifuged at 12,000 rpm for 15 min, repeated 4 times to remove residual NaBH 4 . Finally, place it in an oven at 70°C for 12 hours to obtain the core material black TiO 2 Nanoparticles.

Embodiment 2

[0089] Embodiment 2 core material black ZrO 2 Preparation of spherical nanoparticles

[0090] Take ZrO 2 20.0 grams of powder, 5 grams of sodium borohydride powder, mixed and ground for 30 minutes at room temperature. Put the mixed powder into a tube furnace, raise the temperature to 350° C. at a rate of 10° C. / min under the protection of argon, and heat and react for 4 hours respectively. After the reaction, the powder was dispersed into ultrapure water, centrifuged at 12,000 rpm for 20 minutes, repeated 3 times, then dispersed in absolute ethanol, and centrifuged at 12,000 rpm for 20 minutes to remove residual reactants. The centrifuged precipitate was placed in an oven at 80°C, and black ZrO was obtained after drying. 2 spherical nanoparticles.

Embodiment 3

[0091] Embodiment 3 core material black TiO 2 Preparation of hollow nanospheres

[0092] Take 10 ml of tetraethyl orthosilicate and add it to 200 ml of the mixed solution of ethanol, ammonium hydroxide and water (volume ratio of ethanol: ammonium hydroxide: water = 95:4:1), stir at 25°C for 8 hours, get SiO 2 kernel. 10 ml of isopropyl titanate was added to the reaction solution, and stirring was continued for 8 hours. After the reaction, centrifuge at 12,000 rpm for 30 minutes, repeat washing and centrifugation 3 times to obtain SiO 2 -TiO 2 Core-shell nanospheres. In order to remove SiO 2 core, the SiO 2-TiO 2 The core-shell nanospheres were dispersed in 1 mol / L sodium hydroxide solution and stirred for 6 hours. After the reaction, centrifuged at 12,000 rpm for 30 minutes, repeated washing and centrifuging for 3 times, and dried at 80°C for 6 hours to obtain white TiO 2 Hollow nanosphere powder. Take 5 grams of white TiO 2 Hollow nanospheres and 1.5 grams of sodiu...

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Abstract

The invention provides an application of a nano material in preparation of a medicine for treating atherosclerosis. The nano material comprises a core material, the core material comprises a material A, and the material A is a reduced metal oxide semiconductor nano material. The nano material can be excited by near-infrared light or ultrasonic waves to generate heat and active oxygen, atherosclerotic cell apoptosis is inhibited through the heat effect, lipid metabolism in atherosclerotic cells is regulated and controlled through the heat or the active oxygen, and therefore the treatment effect on atherosclerotic plaques is achieved under the condition that obvious cell death is not caused. The nano material can be bound with atherosclerotic cells, has the ability of targeting atherosclerotic plaque cells, and can improve the treatment effect on atherosclerosis.

Description

technical field [0001] The application relates to the application of a nanometer material as a medicine for treating atherosclerosis, which belongs to the field of biomedical application of nanomaterials. Background technique [0002] The incidence of atherosclerosis is extremely high, and it is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. The rupture of advanced atherosclerotic plaques will lead to serious consequences such as myocardial infarction and cerebral infarction. Therefore, early treatment of atherosclerosis is critical. The clinical treatment of atherosclerotic plaque is mainly based on drug prevention, such as using statins, probucol and other antioxidants to reduce blood lipid levels, or using drugs to dilate blood vessels, protect arterial endothelial cells, and prevent thrombosis . However, some drugs will have side effects after taking them, and oral drugs alone have limited therapeutic effect on atheroscl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P9/10
CPCA61K41/0052A61K41/0057A61P9/10
Inventor 任文智吴爱国戴婷马雪华陈天翔
Owner CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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