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Traditional Chinese medicine compound external preparation for treating chronic wounds as well as preparation process and use method of traditional Chinese medicine compound external preparation

A technology for chronic wounds and external preparations, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc. sufficient and other problems, to achieve good industrialization prospects, uniform and sufficient dosing, and the effect of being conducive to popularization and application

Inactive Publication Date: 2021-12-21
南京市中西医结合医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water solubility of traditional Chinese medicine preparations is not high, the viscosity is high, and the fluidity is poor. It is easy to deposit, stratify, agglomerate, hang on the wall, and distribute unevenly on the wound surface.

Method used

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  • Traditional Chinese medicine compound external preparation for treating chronic wounds as well as preparation process and use method of traditional Chinese medicine compound external preparation
  • Traditional Chinese medicine compound external preparation for treating chronic wounds as well as preparation process and use method of traditional Chinese medicine compound external preparation
  • Traditional Chinese medicine compound external preparation for treating chronic wounds as well as preparation process and use method of traditional Chinese medicine compound external preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The viscosity change of the compound Wufeng Grassland Liquid of embodiment 1 different concentrations

[0028] Take the following weight ratio raw materials: Wufengcao 160-240g, Bletilla striata 15-35g, cat's claw grass 20-60g, set aside; soak the above-mentioned raw materials in 8 times the amount of pure water for 1 hour, then add 5 times the amount of water Decoct for 1 hour to obtain the first extract. Then soak the dregs in 5 times the amount of pure water and decoct for 40 minutes to obtain the second extract. Concentrate the first extract and the second extract into one portion, then precipitate for 24 hours, take the supernatant, and continue to heat and concentrate to obtain the compound Wufeng grassland liquid (currently obtained national patent application number: CN201710423274.5 public number CN107184815A) , the crude drug concentration of the prepared compound Wufeng Grassland Liquid is 2g / ml.

[0029] The concentration of Compound Wufeng Grassland Liqui...

Embodiment 2

[0034] Example 2 Comparison of Curative Effects of External Application of Compound Wufengcao Liquid in Treating 96 Rats with Venous Ulcer Wounds of Lower Limbs

[0035] (1) Experimental objects and groups:

[0036] 96 SD rats (permit number: SCXK (Zhejiang) 2019-0002) provided by the Qinglongshan Animal Farm in Jiangning District, Nanjing, half male and half female, weighing (250±20) g. After successfully establishing the rat model of venous ulcer of lower extremities, 80 rats (half male and half male) were randomly divided into 6 groups, 16 rats in each group. These groups are model group, control group, Chinese medicine preparation group I (use R1 prescription preparation), Chinese medicine preparation group II (use R2 prescription preparation), Chinese medicine preparation III group (use R3 prescription preparation), and Chinese medicine preparation IV group (use R4 prescription preparation). prescription preparations)

[0037] (2) Local wound drug delivery

[0038] 1) ...

Embodiment 3

[0057] Embodiment 3 Formulation prescription fumbles -- the selection of suspending agent

[0058] According to the research of Example 1 and Example 2, a preliminary prescription of the compound Wufengcao suspension was designed, as shown in Table 3, involving prescriptions R5-R13.

[0059] Table 3 Prescription of compound Wufengcao suspension

[0060]

[0061]

[0062] The appearance and sedimentation volume ratio of the above-mentioned prescriptions after long-term storage at room temperature for 60 days were further investigated, and the specific results are shown in Table 4 and Table 5.

[0063] Table 4 Prescription (R5-R8) 60-day storage inspection results at room temperature

[0064]

[0065] Table 5 Prescriptions (R9-R13) placed at room temperature for 60 days to investigate the results

[0066]

[0067] From the above results, it can be seen that: (1) In the prescriptions R5, R6, and R7 with glycerin as the suspending agent, the proportion of glycerin wa...

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Abstract

The invention discloses a traditional Chinese medicine compound external preparation for treating chronic wounds as well as a preparation process and use method of the traditional Chinese medicine compound external preparation. According to the invention, gynura formosana, bletilla striata and radix ranunculi ternati are used as effective components, xanthan gum is added, and water for injection is used as a solvent. The traditional Chinese medicine preparation disclosed by the invention can be used as an external medicine for treating chronic wounds, can be directly smeared on the wounds, can also be combined with a closed negative pressure drainage device to continuously drip and wash the wounds, can slowly and stably release the medicines, and is beneficial to improving the bioavailability of the medicines. Through verification, the traditional Chinese medicine preparation for treating chronic wounds is definite in clinical curative effect. The traditional Chinese medicine preparation is suitable for chronic wounds which cannot achieve the complete state in anatomy and function through a normal, ordered and timely repair process or cannot be healed after being treated for one month or above and have no tendency to heal. The traditional Chinese medicine suspension preparation for treating the chronic wounds is convenient in preparation process, has a good industrialization prospect, is convenient to popularize and apply, and can be used as a choice for improving the dosage form of a traditional Chinese medicine preparation.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine compound external preparation for treating chronic wounds, a preparation process and a use method thereof. Background technique [0002] Chronic wounds usually refer to wounds that are caused by various reasons and cannot achieve anatomical and functional integrity through a normal, orderly and timely repair process, or wounds that have not healed after more than one month of treatment and have no tendency to heal. It can be called refractory wound and is a common clinical disease. Chronic wounds are mainly manifested as local skin damage accompanied by physiological obstacles to tissue repair response. The quality of life of patients also brings a huge economic burden to patients and the social medical system. Clinically, it is common in diabetic ulcers, venous ulcers, pressure ulcers, infectious ulcers, traumatic ulcers, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/10A61K47/36A61P17/02
CPCA61K36/47A61K36/898A61K36/71A61K47/36A61K9/10A61K9/0014A61P17/02A61K2236/331A61K2236/39A61K2300/00
Inventor 黄子慧钱佳燕金全永步中强王裕玲孙佳玥刘万里施金土王旭朱群李鑫
Owner 南京市中西医结合医院
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